Annotations: 6TM2

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6tm2A4	A: beta barrels	X: Repulsive guidance molecule (RGM) family (From Topology)	H: Repulsive guidance molecule (RGM) family (From Topology)	T: Repulsive guidance molecule (RGM) family	F: F_UNCLASSIFIED	ECOD (1.6)
A	TIL	e6tm2A5	A: few secondary structure elements	X: EGF-like	H: Serine protease inhibitors (From Topology)	T: Serine protease inhibitors	F: TIL	ECOD (1.6)
A	F_UNCLASSIFIED	e6tm2A2	A: few secondary structure elements	X: VWF C8-3 module (From Topology)	H: VWF C8-3 module (From Topology)	T: VWF C8-3 module	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6tm2B4	A: beta barrels	X: Repulsive guidance molecule (RGM) family (From Topology)	H: Repulsive guidance molecule (RGM) family (From Topology)	T: Repulsive guidance molecule (RGM) family	F: F_UNCLASSIFIED	ECOD (1.6)
B	TIL	e6tm2B5	A: few secondary structure elements	X: EGF-like	H: Serine protease inhibitors (From Topology)	T: Serine protease inhibitors	F: TIL	ECOD (1.6)
B	F_UNCLASSIFIED	e6tm2B2	A: few secondary structure elements	X: VWF C8-3 module (From Topology)	H: VWF C8-3 module (From Topology)	T: VWF C8-3 module	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e6tm2C1	A: beta barrels	X: Repulsive guidance molecule (RGM) family (From Topology)	H: Repulsive guidance molecule (RGM) family (From Topology)	T: Repulsive guidance molecule (RGM) family	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e6tm2C3	A: few secondary structure elements	X: EGF-like	H: Serine protease inhibitors (From Topology)	T: Serine protease inhibitors	F: F_UNCLASSIFIED	ECOD (1.6)
C	TIL	e6tm2C4	A: few secondary structure elements	X: EGF-like	H: Serine protease inhibitors (From Topology)	T: Serine protease inhibitors	F: TIL	ECOD (1.6)
C	F_UNCLASSIFIED	e6tm2C2	A: few secondary structure elements	X: VWF C8-3 module (From Topology)	H: VWF C8-3 module (From Topology)	T: VWF C8-3 module	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e6tm2D1	A: beta barrels	X: Repulsive guidance molecule (RGM) family (From Topology)	H: Repulsive guidance molecule (RGM) family (From Topology)	T: Repulsive guidance molecule (RGM) family	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e6tm2D3	A: few secondary structure elements	X: EGF-like	H: Serine protease inhibitors (From Topology)	T: Serine protease inhibitors	F: F_UNCLASSIFIED	ECOD (1.6)
D	TIL	e6tm2D4	A: few secondary structure elements	X: EGF-like	H: Serine protease inhibitors (From Topology)	T: Serine protease inhibitors	F: TIL	ECOD (1.6)
D	F_UNCLASSIFIED	e6tm2D2	A: few secondary structure elements	X: VWF C8-3 module (From Topology)	H: VWF C8-3 module (From Topology)	T: VWF C8-3 module	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08742	C8 domain (C8)	C8 domain	This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often fo ...	This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing Pfam:PF00094 and Pfam:PF01826.	Domain
A, B	PF01826	Trypsin Inhibitor like cysteine rich domain (TIL)	Trypsin Inhibitor like cysteine rich domain	This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, ...	This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.	Domain
A, B	PF00094	von Willebrand factor type D domain (VWD)	von Willebrand factor type D domain	Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods. This domain is structurally homologous to the C-terminal domain of repulsive guidance molecules (RGM) despite low sequence identity [2 ...	Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods. This domain is structurally homologous to the C-terminal domain of repulsive guidance molecules (RGM) despite low sequence identity [2].	Domain
C, D	PF08742	C8 domain (C8)	C8 domain	This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often fo ...	This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing Pfam:PF00094 and Pfam:PF01826.	Domain
C, D	PF00094	von Willebrand factor type D domain (VWD)	von Willebrand factor type D domain	Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods. This domain is structurally homologous to the C-terminal domain of repulsive guidance molecules (RGM) despite low sequence identity [2 ...	Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods. This domain is structurally homologous to the C-terminal domain of repulsive guidance molecules (RGM) despite low sequence identity [2].	Domain
E, F	PF13330	Mucin-2 protein WxxW repeating region (Mucin2_WxxW)	Mucin-2 protein WxxW repeating region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Mucin-2	cation binding cuprous ion binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding cupric ion binding	multicellular organismal process maintenance of gastrointestinal epithelium system process digestion multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process digestive system process anatomical structure homeostasis tissue homeostasis detoxification of inorganic compound response to copper ion detoxification of copper ion response to stimulus multicellular organismal process maintenance of gastrointestinal epithelium system process digestion multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process digestive system process anatomical structure homeostasis tissue homeostasis detoxification of inorganic compound response to copper ion detoxification of copper ion response to stimulus detoxification stress response to copper ion response to toxic substance response to metal ion response to chemical response to stress stress response to metal ion biological process involved in interspecies interaction between organisms homeostasis of number of cells host-mediated regulation of intestinal microbiota composition modulation of process of another organism host-mediated perturbation of symbiont process regulation of body fluid levels secretion by tissue secretion transport biological regulation mucus secretion establishment of localization body fluid secretion localization regulation of biological quality	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular region membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular region outer mucus layer mucus layer cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix plasma membrane membrane inner mucus layer extracellular space
C, D	Mucin-2	cation binding cuprous ion binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding cupric ion binding	multicellular organismal process maintenance of gastrointestinal epithelium system process digestion multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process digestive system process anatomical structure homeostasis tissue homeostasis detoxification of inorganic compound response to copper ion detoxification of copper ion response to stimulus multicellular organismal process maintenance of gastrointestinal epithelium system process digestion multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process digestive system process anatomical structure homeostasis tissue homeostasis detoxification of inorganic compound response to copper ion detoxification of copper ion response to stimulus detoxification stress response to copper ion response to toxic substance response to metal ion response to chemical response to stress stress response to metal ion biological process involved in interspecies interaction between organisms homeostasis of number of cells host-mediated regulation of intestinal microbiota composition modulation of process of another organism host-mediated perturbation of symbiont process regulation of body fluid levels secretion by tissue secretion transport biological regulation mucus secretion establishment of localization body fluid secretion localization regulation of biological quality	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular region membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular region outer mucus layer mucus layer cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix plasma membrane membrane inner mucus layer extracellular space
E, F	Mucin-2	cation binding cuprous ion binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding cupric ion binding	multicellular organismal process maintenance of gastrointestinal epithelium system process digestion multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process digestive system process anatomical structure homeostasis tissue homeostasis detoxification of inorganic compound response to copper ion detoxification of copper ion response to stimulus multicellular organismal process maintenance of gastrointestinal epithelium system process digestion multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process digestive system process anatomical structure homeostasis tissue homeostasis detoxification of inorganic compound response to copper ion detoxification of copper ion response to stimulus detoxification stress response to copper ion response to toxic substance response to metal ion response to chemical response to stress stress response to metal ion biological process involved in interspecies interaction between organisms homeostasis of number of cells host-mediated regulation of intestinal microbiota composition modulation of process of another organism host-mediated perturbation of symbiont process regulation of body fluid levels secretion by tissue secretion transport biological regulation mucus secretion establishment of localization body fluid secretion localization regulation of biological quality	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular region membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular region outer mucus layer mucus layer cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix plasma membrane membrane inner mucus layer extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR050780	Mucin/von Willebrand/Thrombospondin superfamily	Family
A, B	IPR002919	Trypsin Inhibitor-like, cysteine rich domain	Domain
A, B	IPR001007	VWFC domain	Domain
A, B	IPR001846	von Willebrand factor, type D domain	Domain
A, B	IPR014853	VWF/SSPO/Zonadhesin-like, cysteine-rich domain	Domain
A, B	IPR036084	Serine protease inhibitor-like superfamily	Homologous Superfamily
A, B	IPR025155	WxxW domain	Domain
A, B	IPR006207	Cystine knot, C-terminal	Domain
C, D	IPR050780	Mucin/von Willebrand/Thrombospondin superfamily	Family
C, D	IPR002919	Trypsin Inhibitor-like, cysteine rich domain	Domain
C, D	IPR001007	VWFC domain	Domain
C, D	IPR001846	von Willebrand factor, type D domain	Domain
C, D	IPR014853	VWF/SSPO/Zonadhesin-like, cysteine-rich domain	Domain
C, D	IPR036084	Serine protease inhibitor-like superfamily	Homologous Superfamily
C, D	IPR025155	WxxW domain	Domain
C, D	IPR006207	Cystine knot, C-terminal	Domain
E, F	IPR050780	Mucin/von Willebrand/Thrombospondin superfamily	Family
E, F	IPR002919	Trypsin Inhibitor-like, cysteine rich domain	Domain
E, F	IPR001007	VWFC domain	Domain
E, F	IPR001846	von Willebrand factor, type D domain	Domain
E, F	IPR014853	VWF/SSPO/Zonadhesin-like, cysteine-rich domain	Domain
E, F	IPR036084	Serine protease inhibitor-like superfamily	Homologous Superfamily
E, F	IPR025155	WxxW domain	Domain
E, F	IPR006207	Cystine knot, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q02817	adenocarcinoma adenoma intestinal cancer papillary adenoma rectal neoplasm follicular thyroid adenoma microcystic adenoma tubular adenocarcinoma granular cell carcinoma rectal carcinoma ulcerative colitis Adenoma, Trabecular Crohn disease malignant colon neoplasm cribriform carcinoma adenocarcinoma adenoma intestinal cancer papillary adenoma rectal neoplasm follicular thyroid adenoma microcystic adenoma tubular adenocarcinoma granular cell carcinoma rectal carcinoma ulcerative colitis Adenoma, Trabecular Crohn disease malignant colon neoplasm cribriform carcinoma intestinal neoplasm rectal cancer cribriform carcinoma of breast pancreatic intraductal papillary-mucinous carcinoma
C, D	Pharos: Q02817	adenocarcinoma adenoma intestinal cancer papillary adenoma rectal neoplasm follicular thyroid adenoma microcystic adenoma tubular adenocarcinoma granular cell carcinoma rectal carcinoma ulcerative colitis Adenoma, Trabecular Crohn disease malignant colon neoplasm cribriform carcinoma adenocarcinoma adenoma intestinal cancer papillary adenoma rectal neoplasm follicular thyroid adenoma microcystic adenoma tubular adenocarcinoma granular cell carcinoma rectal carcinoma ulcerative colitis Adenoma, Trabecular Crohn disease malignant colon neoplasm cribriform carcinoma intestinal neoplasm rectal cancer cribriform carcinoma of breast pancreatic intraductal papillary-mucinous carcinoma
E, F	Pharos: Q02817	adenocarcinoma adenoma intestinal cancer papillary adenoma rectal neoplasm follicular thyroid adenoma microcystic adenoma tubular adenocarcinoma granular cell carcinoma rectal carcinoma ulcerative colitis Adenoma, Trabecular Crohn disease malignant colon neoplasm cribriform carcinoma adenocarcinoma adenoma intestinal cancer papillary adenoma rectal neoplasm follicular thyroid adenoma microcystic adenoma tubular adenocarcinoma granular cell carcinoma rectal carcinoma ulcerative colitis Adenoma, Trabecular Crohn disease malignant colon neoplasm cribriform carcinoma intestinal neoplasm rectal cancer cribriform carcinoma of breast pancreatic intraductal papillary-mucinous carcinoma