Annotations: 6TM6

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13330	Mucin-2 protein WxxW repeating region (Mucin2_WxxW)	Mucin-2 protein WxxW repeating region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Mucin-2	cation binding cuprous ion binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding cupric ion binding	multicellular organismal process maintenance of gastrointestinal epithelium system process digestion multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process digestive system process anatomical structure homeostasis tissue homeostasis detoxification of inorganic compound response to copper ion detoxification of copper ion response to stimulus multicellular organismal process maintenance of gastrointestinal epithelium system process digestion multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process digestive system process anatomical structure homeostasis tissue homeostasis detoxification of inorganic compound response to copper ion detoxification of copper ion response to stimulus detoxification stress response to copper ion response to toxic substance response to metal ion response to chemical response to stress stress response to metal ion biological process involved in interspecies interaction between organisms homeostasis of number of cells host-mediated regulation of intestinal microbiota composition modulation of process of another organism host-mediated perturbation of symbiont process regulation of body fluid levels secretion by tissue secretion transport biological regulation mucus secretion establishment of localization body fluid secretion localization regulation of biological quality	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular region membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular region outer mucus layer mucus layer cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix plasma membrane membrane inner mucus layer extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050780	Mucin/von Willebrand/Thrombospondin superfamily	Family
A	IPR002919	Trypsin Inhibitor-like, cysteine rich domain	Domain
A	IPR001007	VWFC domain	Domain
A	IPR001846	von Willebrand factor, type D domain	Domain
A	IPR014853	VWF/SSPO/Zonadhesin-like, cysteine-rich domain	Domain
A	IPR036084	Serine protease inhibitor-like superfamily	Homologous Superfamily
A	IPR025155	WxxW domain	Domain
A	IPR006207	Cystine knot, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q02817	adenocarcinoma adenoma intestinal cancer papillary adenoma rectal neoplasm follicular thyroid adenoma microcystic adenoma tubular adenocarcinoma granular cell carcinoma rectal carcinoma ulcerative colitis Adenoma, Trabecular Crohn disease malignant colon neoplasm cribriform carcinoma adenocarcinoma adenoma intestinal cancer papillary adenoma rectal neoplasm follicular thyroid adenoma microcystic adenoma tubular adenocarcinoma granular cell carcinoma rectal carcinoma ulcerative colitis Adenoma, Trabecular Crohn disease malignant colon neoplasm cribriform carcinoma intestinal neoplasm rectal cancer cribriform carcinoma of breast pancreatic intraductal papillary-mucinous carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.