Annotations: 6U00

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	AAA_33	e6u00A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: AAA_33	ECOD (1.6)
B	AAA_33	e6u00B1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: AAA_33	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08302	Fungal tRNA ligase phosphodiesterase domain (tRNA_lig_CPD)	Fungal tRNA ligase phosphodiesterase domain	This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity [1]. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.	Domain
A, B	PF08303	tRNA ligase kinase domain (tRNA_lig_kinase)	tRNA ligase kinase domain	This domain is found in fungal tRNA ligases and has kinase activity [1]. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns. This family contains a P-loop motif.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	tRNA ligase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ligase activity, forming phosphoric ester bonds RNA ligase (ATP) activity catalytic activity, acting on RNA RNA ligase activity catalytic activity, acting on a nucleic acid catalytic activity ligase activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity hydrolase activity 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity cyclic-nucleotide phosphodiesterase activity endonuclease activity nuclease activity nucleobase-containing compound kinase activity polynucleotide 5'-hydroxyl-kinase activity GTP-dependent polynucleotide 5'-hydroxyl-kinase activity kinase activity transferase activity GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups	regulation of cellular process catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of biological process RNA metabolic process macromolecule catabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process regulation of mRNA catabolic process negative regulation of cellular process regulation of nucleobase-containing compound metabolic process RNA catabolic process negative regulation of macromolecule metabolic process regulation of cellular process catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of biological process RNA metabolic process macromolecule catabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process regulation of mRNA catabolic process negative regulation of cellular process regulation of nucleobase-containing compound metabolic process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process regulation of biological process nuclear-transcribed mRNA catabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nucleobase-containing compound catabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of mRNA metabolic process regulation of metabolic process nuclear-transcribed mRNA catabolic process, no-go decay cellular response to stimulus cellular response to topologically incorrect protein response to stimulus signaling endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein intracellular signal transduction cell communication cellular response to stress response to stress response to topologically incorrect protein IRE1-mediated unfolded protein response signal transduction response to endoplasmic reticulum stress positive regulation of protein metabolic process positive regulation of biological process positive regulation of translation protein biosynthetic process positive regulation of macromolecule biosynthetic process post-transcriptional regulation of gene expression positive regulation of metabolic process regulation of translation in response to stress positive regulation of biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of translation in response to stress positive regulation of cellular process regulation of protein metabolic process translation positive regulation of gene expression regulation of translation RNA splicing nucleobase-containing compound biosynthetic process RNA biosynthetic process tRNA metabolic process tRNA splicing, via endonucleolytic cleavage and ligation nucleic acid biosynthetic process RNA splicing, via endonucleolytic cleavage and ligation tRNA processing RNA processing	membrane-bounded organelle intracellular anatomical structure organelle inner membrane nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear inner membrane nuclear envelope membrane-bounded organelle intracellular anatomical structure organelle inner membrane nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear inner membrane nuclear envelope organelle membrane cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012387	tRNA ligase Trl1, fungi	Family
A, B	IPR019039	T4 RNA ligase 1-like, N-terminal	Domain
A, B	IPR015965	tRNA ligase, phosphodiesterase	Domain
A, B	IPR015966	tRNA ligase, kinase domain, fungi	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.