7BU7
Structure of human beta1 adrenergic receptor bound to BI-167107 and nanobody 6B9
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
- Membrane Protein Annotation: PDBTM
- Membrane Protein Annotation: mpstruc
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d7bu7b1 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | automated matches | automated matches | (Camelidae mixed library ) [TaxId: 1579311 ], | SCOPe (2.08) |
B | d7bu7b3 | Artifacts | Tags | Tags | Tags | C-terminal Tags | (Camelidae mixed library ) [TaxId: 1579311 ], | SCOPe (2.08) |
B | d7bu7b2 | Artifacts | Tags | Tags | Tags | N-terminal Tags | (Camelidae mixed library ) [TaxId: 1579311 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | 7tm_1_2 | e7bu7A1 | A: alpha bundles | X: Family A G protein-coupled receptor-like (From Topology) | H: Family A G protein-coupled receptor-like (From Topology) | T: Family A G protein-coupled receptor-like | F: 7tm_1_2 | ECOD (1.6) |
A | Phage_lysozyme_2 | e7bu7A2 | A: a+b complex topology | X: Lysozyme-like (From Homology) | H: Lysozyme-like | T: Lysozyme-like | F: Phage_lysozyme_2 | ECOD (1.6) |
B | V-set_1 | e7bu7B1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_1 | ECOD (1.6) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
nAb 6B9 | VH | Vicugna pacos (alpaca) | IGHV3S53*01, IGHJ4*01 | V-DOMAIN VH | IG | VH | IMGT (202449-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
Heavy Chain | IGHV1 | - | endolysin,endolysin,beta-1 adrenergic receptor chimera | SAbDab (2024-12-13) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00959 | Phage lysozyme (Phage_lysozyme) | Phage lysozyme | This family includes lambda phage lysozyme and E. coli endolysin. | Domain | |
PF00001 | 7 transmembrane receptor (rhodopsin family) (7tm_1) | 7 transmembrane receptor (rhodopsin family) | - | Family | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR052619 | Bacteriophage lysozyme-like | Family | |
IPR001165 | T4-type lysozyme | Family | |
IPR034690 | Endolysin T4 type | Family | |
IPR002196 | Glycoside hydrolase, family 24 | Family | |
IPR023347 | Lysozyme domain superfamily | Homologous Superfamily | |
IPR023346 | Lysozyme-like domain superfamily | Homologous Superfamily | |
IPR000276 | G protein-coupled receptor, rhodopsin-like | Family | |
IPR002233 | Adrenoceptor family | Family | |
IPR017452 | GPCR, rhodopsin-like, 7TM | Domain | |
IPR000507 | Beta 1 adrenoceptor | Family |
Pharos: Disease Associations Pharos Homepage Annotation
Membrane Protein Annotation: PDBTM PDBTM Database Homepage
Chains | External Link | Comment |
---|---|---|
PDBTM | Annotated as membrane protein by PDBTM |
Membrane Protein Annotation: mpstruc mpstruc Database Homepage
Chains | Resource Link | Group | Subgroup | Protein |
---|---|---|---|---|
mpstruc | TRANSMEMBRANE PROTEINS: ALPHA-HELICAL | G Protein-Coupled Receptors: Class A | β1 adrenergic receptor bound to carazolol |