7PJC | pdb_00007pjc

The structure of Candida albicans phosphoglucomutase with isothiazolone modification on Cys359

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	PGM_PMM_IV_1	e7pjcA1	A: a+b two layers	X: TBP-like	H: Phosphoglucomutase, C-terminal domain (From Topology)	T: Phosphoglucomutase, C-terminal domain	F: PGM_PMM_IV_1	ECOD (1.6)
B [auth A]	PGM_PMM_I	e7pjcA3	A: a/b three-layered sandwiches	X: Phosphoglucomutase, first 3 domains (From Topology)	H: Phosphoglucomutase, first 3 domains (From Topology)	T: Phosphoglucomutase, first 3 domains	F: PGM_PMM_I	ECOD (1.6)
B [auth A]	PGM_PMM_II	e7pjcA2	A: a/b three-layered sandwiches	X: Phosphoglucomutase, first 3 domains (From Topology)	H: Phosphoglucomutase, first 3 domains (From Topology)	T: Phosphoglucomutase, first 3 domains	F: PGM_PMM_II	ECOD (1.6)
B [auth A]	PGM_PMM_III_1	e7pjcA4	A: a/b three-layered sandwiches	X: Phosphoglucomutase, first 3 domains (From Topology)	H: Phosphoglucomutase, first 3 domains (From Topology)	T: Phosphoglucomutase, first 3 domains	F: PGM_PMM_III_1	ECOD (1.6)
A [auth B]	PGM_PMM_IV_1	e7pjcB1	A: a+b two layers	X: TBP-like	H: Phosphoglucomutase, C-terminal domain (From Topology)	T: Phosphoglucomutase, C-terminal domain	F: PGM_PMM_IV_1	ECOD (1.6)
A [auth B]	PGM_PMM_I	e7pjcB4	A: a/b three-layered sandwiches	X: Phosphoglucomutase, first 3 domains (From Topology)	H: Phosphoglucomutase, first 3 domains (From Topology)	T: Phosphoglucomutase, first 3 domains	F: PGM_PMM_I	ECOD (1.6)
A [auth B]	PGM_PMM_II	e7pjcB2	A: a/b three-layered sandwiches	X: Phosphoglucomutase, first 3 domains (From Topology)	H: Phosphoglucomutase, first 3 domains (From Topology)	T: Phosphoglucomutase, first 3 domains	F: PGM_PMM_II	ECOD (1.6)
A [auth B]	PGM_PMM_III_1	e7pjcB3	A: a/b three-layered sandwiches	X: Phosphoglucomutase, first 3 domains (From Topology)	H: Phosphoglucomutase, first 3 domains (From Topology)	T: Phosphoglucomutase, first 3 domains	F: PGM_PMM_III_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	3.40.120.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha-D-Glucose-1,6-Bisphosphate	Chain A, domain 3	CATH (utative)
B [auth A]	3.30.310.50	Alpha Beta	2-Layer Sandwich	TATA-Binding Protein	Alpha-D-phosphohexomutase, C-terminal domain	CATH (utative)
A [auth B]	3.40.120.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha-D-Glucose-1,6-Bisphosphate	Chain A, domain 3	CATH (utative)
A [auth B]	3.30.310.50	Alpha Beta	2-Layer Sandwich	TATA-Binding Protein	Alpha-D-phosphohexomutase, C-terminal domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF02878	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I (PGM_PMM_I)	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I		Domain
A [auth B], B [auth A]	PF02879	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II (PGM_PMM_II)	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II		Domain
A [auth B], B [auth A]	PF02880	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III (PGM_PMM_III)	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III		Domain
A [auth B], B [auth A]	PF24947	Phosphoglucomutase-1, C-terminal domain (PGM1_C_vert_fung)	Phosphoglucomutase-1, C-terminal domain	This entry represents the C-terminal domain of phosphoglucomutase-1 (PGM1) from human, and its homologues from vertebrates and fungi, which catalyses the bi-directional interconversion between alpha-D-glucose 1-phosphate (G1P) and alpha-D-glucose 6-p ...	This entry represents the C-terminal domain of phosphoglucomutase-1 (PGM1) from human, and its homologues from vertebrates and fungi, which catalyses the bi-directional interconversion between alpha-D-glucose 1-phosphate (G1P) and alpha-D-glucose 6-phosphate (G6P), a reaction that is essential for normal carbohydrate metabolism and is also important in the cytoplasmic biosynthesis of nucleotide sugars needed for glycan biosynthesis [2-5]. This domain contains a six-stranded antiparallel beta-sheet with two alpha-helices lying on the face of the sheet opposite the active site which is located centrally, in a deep cleft between the four domains of these proteins [1-5]. This domain contains the phosphate-binding loop which interacts with the substrate phosphate moiety [5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Phosphoglucomutase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding phosphoglucomutase activity isomerase activity intramolecular phosphotransferase activity catalytic activity intramolecular transferase activity	carbohydrate metabolic process primary metabolic process metabolic process cellular process glucose 1-phosphate metabolic process organophosphate metabolic process phosphate-containing compound metabolic process carbohydrate derivative metabolic process phosphorus metabolic process nucleoside phosphate metabolic process UDP-alpha-D-glucose metabolic process nucleotide-sugar metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process carbohydrate metabolic process primary metabolic process metabolic process cellular process glucose 1-phosphate metabolic process organophosphate metabolic process phosphate-containing compound metabolic process carbohydrate derivative metabolic process phosphorus metabolic process nucleoside phosphate metabolic process UDP-alpha-D-glucose metabolic process nucleotide-sugar metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process small molecule metabolic process glucose 6-phosphate metabolic process monosaccharide metabolic process catabolic process hexose catabolic process carbohydrate catabolic process galactose catabolic process hexose metabolic process galactose metabolic process monosaccharide catabolic process small molecule catabolic process glucose metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR045244	Phosphoglucomutase	Family
A [auth B], B [auth A]	IPR005846	Alpha-D-phosphohexomutase, alpha/beta/alpha domain III	Domain
A [auth B], B [auth A]	IPR005845	Alpha-D-phosphohexomutase, alpha/beta/alpha domain II	Domain
A [auth B], B [auth A]	IPR016055	Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III	Homologous Superfamily
A [auth B], B [auth A]	IPR016066	Alpha-D-phosphohexomutase, conserved site	Conserved Site
A [auth B], B [auth A]	IPR005844	Alpha-D-phosphohexomutase, alpha/beta/alpha domain I	Domain
A [auth B], B [auth A]	IPR005841	Alpha-D-phosphohexomutase superfamily	Family
A [auth B], B [auth A]	IPR036900	Alpha-D-phosphohexomutase, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.