7PWD
Structure of an inhibited GRK2-G-beta and G-gamma complex
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | PH domain-like | 8042573 | 3000134 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | WD40 repeat-like | 8042849 | 3001694 | SCOP2B (2022-06-29) |
C [auth G] | SCOP2B Superfamily | Transducin (heterotrimeric G protein), gamma chain | 8070796 | 3001771 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PH | e7pwdA3 | A: beta barrels | X: PH domain-like | H: PH domain-like (From Topology) | T: PH domain-like | F: PH | ECOD (1.6) |
A | RGS | e7pwdA2 | A: alpha bundles | X: Regulator of G-protein signaling, RGS (From Topology) | H: Regulator of G-protein signaling, RGS (From Topology) | T: Regulator of G-protein signaling, RGS | F: RGS | ECOD (1.6) |
A | Pkinase_Tyr | e7pwdA1 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: Protein kinase | F: Pkinase_Tyr | ECOD (1.6) |
B | ANAPC4_WD40_3 | e7pwdB1 | A: beta duplicates or obligate multimers | X: beta-propeller-like | H: beta-propeller | T: 7-bladed | F: ANAPC4_WD40_3 | ECOD (1.6) |
C [auth G] | G-gamma | e7pwdG1 | A: extended segments | X: Transducin (heterotrimeric G protein), gamma chain (From Topology) | H: Transducin (heterotrimeric G protein), gamma chain (From Topology) | T: Transducin (heterotrimeric G protein), gamma chain | F: G-gamma | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00615 | Regulator of G protein signaling domain (RGS) | Regulator of G protein signaling domain | RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits. | Domain | |
PF00069 | Protein kinase domain (Pkinase) | Protein kinase domain | - | Domain | |
PF00169 | PH domain (PH) | PH domain | PH stands for pleckstrin homology. | Domain | |
PF00400 | WD domain, G-beta repeat (WD40) | WD domain, G-beta repeat | - | Repeat | |