Annotations: 8C84

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00319	SRF-type transcription factor (DNA-binding and dimerisation domain) (SRF-TF)	SRF-type transcription factor (DNA-binding and dimerisation domain)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	MEF2D protein	histone deacetylase binding protein binding binding enzyme binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding histone deacetylase binding protein binding binding enzyme binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein dimerization activity transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific identical protein binding protein homodimerization activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation apoptotic process cell death programmed cell death muscle structure development animal organ development anatomical structure development muscle organ development developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation apoptotic process cell death programmed cell death muscle structure development animal organ development anatomical structure development muscle organ development regulation of vascular associated smooth muscle cell proliferation regulation of biological process cell population proliferation regulation of cellular process positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation biological regulation positive regulation of biological process smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation positive regulation of cellular process endochondral ossification replacement ossification endochondral bone morphogenesis multicellular organism development anatomical structure morphogenesis skeletal system development skeletal system morphogenesis animal organ morphogenesis bone morphogenesis bone development system development skeletal muscle cell differentiation skeletal muscle tissue development tissue development striated muscle tissue development skeletal muscle organ development muscle tissue development nervous system development connective tissue development chondrocyte differentiation cartilage development heart development adult heart development circulatory system development positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen membraneless organelle membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen membraneless organelle intracellular membraneless organelle chromatin chromosome
C [auth K]	DNA (5'-D(PAPAPCPTPAPTPTPTPAPTPAPAPGPA)-3')	-	-	-
D [auth L]	DNA (5'-D(PTPCPTPTPAPTPAPAPAPTPAPGPTPT)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR022102	Holliday junction regulator protein family C-terminal	Domain
A, B	IPR033896	MADS MEF2-like, N-terminal	Domain
A, B	IPR036879	Transcription factor, MADS-box superfamily	Homologous Superfamily
A, B	IPR002100	Transcription factor, MADS-box	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q14814	migraine without aura, susceptibility to, 4 atypical teratoid rhabdoid tumor malignant ependymoma migraine disorder primitive neuroectodermal tumor glioblastoma malignant glioma large cell medulloblastoma medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.