8F6O | pdb_00008f6o

anti-BTLA monoclonal antibody h22B3 in complex with BTLA

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: CATH
SAbDab Antibody Annotation
Thera-SAbDab Antibody Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054539	3000071	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Light Chain	IGKV3	Kappa	b- and t-lymphocyte attenuator	SAbDab (2025-12-05)
A	Heavy Chain	IGHV1	-	b- and t-lymphocyte attenuator	SAbDab (2025-12-05)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

Chain	Name	Target	Provenance Source
B	Venanprubart	BTLA/CD272	Therapeutic SAbDab (2025-12-05)
A	Venanprubart	BTLA/CD272	Therapeutic SAbDab (2025-12-05)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C	B- and T-lymphocyte attenuator	molecular transducer activity signaling receptor activity	cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling immune response biological regulation cell communication immune response-regulating signaling pathway regulation of response to stimulus immune system process regulation of immune response cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling immune response biological regulation cell communication immune response-regulating signaling pathway regulation of response to stimulus immune system process regulation of immune response cellular process regulation of immune system process signal transduction negative regulation of lymphocyte proliferation multicellular organismal process regulation of leukocyte activation negative regulation of biological process regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion negative regulation of cellular process regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation adaptive immune response	cell periphery cellular anatomical structure plasma membrane membrane
B	h22B3 Fab light chain	-	-	-
A	h22B3 Fab heavy chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C	IPR039257	B- and T-lymphocyte attenuator	Family
C	IPR003599	Immunoglobulin domain subtype	Domain
C	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C	Pharos: Q7Z6A9	interstitial cystitis osteosarcoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	PCA	Parent Component: GLN RESID: AA0031 PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.