Warning
You are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox.
Help
Contact us
Toggle navigation
RCSB PDB
Deposit
Prepare Data
PDBx/mmCIF file
pdb_extract
SF-Tool
Ligand Expo
MAXIT
Validate Data
Validation Server
Validation API
Information for Journals
Validation Task Forces
Deposit Data
wwPDB OneDep System
PDB-Dev
Help and Resources
Deposit FAQ
Validation FAQ
Tutorials
Annotation Policies
Processing Procedures
PDBx/mmCIF Dictionary
PDBx/mmCIF User Guide
Chemical Component Dictionary
Biologically Interesting Molecule Reference Dictionary (BIRD)
BioSync/Beamlines/Facilities
Related Tools
Search
Advanced Search
Sequence Similarity Search
Structure Similarity Search
Chemical Similarity Search
Chemical Sketch Tool
Browse by Annotations
New Entries
Unreleased Entries
PDB Statistics
Visualize
Mol* (MolStar)
Sequence Annotations Viewer
Genome View
Analyze
Pairwise Structure Alignment
Symmetry Resources in the PDB
Structure Quality
Grouping Structures
PDB Citation MeSH Network Explorer
PDB Statistics
EPPIC Biological Assemblies
External Data and Resources
Integrated Resources
Additional Resources
Download
Coordinates and Experimental Data
Sequences
Ligands
File Download Services
Web APIs
Learn
Training Courses
Guide to PDB Data
Molecule of the Month
Educational Resources
Curricula
Browse
News
SciArt Galleries
Irving Geis
David Goodsell
About
Contact Us
About RCSB PDB
Vision and Mission
Citation, Usage, Privacy Policies, Logo
News
PDB History
PDB50
User Community
Publications
RCSB PDB Advisory Committee
Team Members
Diversity, Equity, Inclusion, and Access
Service Status
Careers
COVID-19
229,564
Structures from the PDB
1,068,577
Computed Structure Models (CSM)
Navigation Tabs
Structure Summary
Structure
Annotations
Experiment
Sequence
Genome
Ligands
Versions
Display Files
FASTA Sequence
mmCIF Format
mmCIF Format (Header)
PDB Format
PDB Format (Header)
Download Files
FASTA Sequence
PDBx/mmCIF Format
PDBx/mmCIF Format (gz)
BinaryCIF Format (gz)
PDB Format
PDB Format (gz)
PDBML/XML Format (gz)
Structure Factors (CIF)
Structure Factors (CIF - gz)
Validation Full PDF
Validation (XML - gz)
Validation (CIF - gz)
Validation 2fo-fc coefficients (CIF - gz)
Validation fo-fc coefficients (CIF - gz)
Biological Assembly 1 (CIF - gz)
Biological Assembly 1 (PDB - gz)
Data API
8REP
Crystal structure of oxidized ThyX-Y91F mutant
External Resource: Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Gene Ontology: Gene Product Annotation
Gene Ontology Database Homepage
Chains
Polymer
Molecular Function
Biological Process
Cellular Component
A
,
B
,
C
,
D
Flavin-dependent thymidylate synthase
binding
nucleotide binding
nucleoside phosphate binding
ion binding
purine nucleotide binding
organic cyclic compound binding
anion binding
adenyl nucleotide binding
heterocyclic compound binding
NADPH binding
NADP binding
small molecule binding
transferase activity, transferring one-carbon groups
transferase activity
binding
nucleotide binding
nucleoside phosphate binding
ion binding
purine nucleotide binding
organic cyclic compound binding
anion binding
adenyl nucleotide binding
heterocyclic compound binding
NADPH binding
NADP binding
small molecule binding
transferase activity, transferring one-carbon groups
transferase activity
methyltransferase activity
thymidylate synthase activity
5,10-methylenetetrahydrofolate-dependent methyltransferase activity
catalytic activity
thymidylate synthase (FAD) activity
flavin adenine dinucleotide binding
Less
methylation
metabolic process
cellular process
pyrimidine deoxyribonucleotide metabolic process
deoxyribose phosphate biosynthetic process
nucleotide biosynthetic process
carbohydrate derivative metabolic process
pyrimidine nucleotide metabolic process
pyrimidine deoxyribonucleoside monophosphate metabolic process
nucleobase-containing compound metabolic process
deoxyribonucleotide biosynthetic process
deoxyribonucleotide metabolic process
pyrimidine deoxyribonucleotide biosynthetic process
nucleobase-containing small molecule metabolic process
methylation
metabolic process
cellular process
pyrimidine deoxyribonucleotide metabolic process
deoxyribose phosphate biosynthetic process
nucleotide biosynthetic process
carbohydrate derivative metabolic process
pyrimidine nucleotide metabolic process
pyrimidine deoxyribonucleoside monophosphate metabolic process
nucleobase-containing compound metabolic process
deoxyribonucleotide biosynthetic process
deoxyribonucleotide metabolic process
pyrimidine deoxyribonucleotide biosynthetic process
nucleobase-containing small molecule metabolic process
dTMP metabolic process
phosphate-containing compound metabolic process
deoxyribonucleoside monophosphate biosynthetic process
dTMP biosynthetic process
small molecule metabolic process
pyrimidine deoxyribonucleoside monophosphate biosynthetic process
pyrimidine-containing compound biosynthetic process
nucleoside monophosphate metabolic process
phosphorus metabolic process
nucleoside phosphate metabolic process
carbohydrate derivative biosynthetic process
pyrimidine nucleoside monophosphate metabolic process
pyrimidine-containing compound metabolic process
2'-deoxyribonucleotide metabolic process
2'-deoxyribonucleotide biosynthetic process
primary metabolic process
nucleotide metabolic process
deoxyribose phosphate metabolic process
nucleobase-containing compound biosynthetic process
deoxyribonucleoside monophosphate metabolic process
nucleoside monophosphate biosynthetic process
biosynthetic process
organophosphate metabolic process
organophosphate biosynthetic process
nucleoside phosphate biosynthetic process
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
pyrimidine deoxyribonucleoside triphosphate biosynthetic process
dTTP biosynthetic process
pyrimidine deoxyribonucleoside triphosphate metabolic process
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine nucleoside triphosphate metabolic process
dTTP metabolic process
nucleoside triphosphate biosynthetic process
nucleoside triphosphate metabolic process
Less
-
InterPro: Protein Family Classification
InterPro Database Homepage
Chains
Accession
Name
Type
A
,
B
,
C
,
D
IPR003669
Thymidylate synthase ThyX
Family
A
,
B
,
C
,
D
IPR036098
Thymidylate synthase ThyX superfamily
Homologous Superfamily
About
About Us
Citing Us
Publications
Team
Careers
Usage & Privacy
Support
Contact Us
Help
Website FAQ
Glossary
Service Status
RCSB PDB is hosted by
RCSB PDB is a member of the
RCSB Partners
Nucleic Acid Knowledgebase
wwPDB Partners
RCSB PDB
PDBe
PDBj
BMRB
EMDB