9HJN | pdb_00009hjn

Structure of UDP-Galactose-4-epimerase (GalE) bound to fragment from Diamond XChem experiment.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SDR-like	8058493	3000038	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SDR-like	8058493	3000038	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16363	GDP-mannose 4,6 dehydratase (GDP_Man_Dehyd)	GDP-mannose 4,6 dehydratase		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	UDP-glucose 4-epimerase	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity isomerase activity racemase and epimerase activity UDP-N-acetylglucosamine 4-epimerase activity racemase and epimerase activity, acting on carbohydrates and derivatives catalytic activity UDP-glucose 4-epimerase activity	monosaccharide metabolic process carbohydrate metabolic process carbohydrate derivative catabolic process catabolic process hexose catabolic process carbohydrate catabolic process galactose catabolic process carbohydrate derivative metabolic process organophosphate catabolic process hexose metabolic process primary metabolic process galactose metabolic process galactose catabolic process via UDP-galactose, Leloir pathway organophosphate metabolic process phosphate-containing compound metabolic process monosaccharide metabolic process carbohydrate metabolic process carbohydrate derivative catabolic process catabolic process hexose catabolic process carbohydrate catabolic process galactose catabolic process carbohydrate derivative metabolic process organophosphate catabolic process hexose metabolic process primary metabolic process galactose metabolic process galactose catabolic process via UDP-galactose, Leloir pathway organophosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process metabolic process cellular process monosaccharide catabolic process small molecule catabolic process phosphorus metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR005886	UDP-glucose 4-epimerase	Family
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR016040	NAD(P)-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q14376	galactosemia galactose epimerase deficiency galactokinase deficiency tinea pedis breast cancer dermatophytosis of groin and perianal area intellectual disability malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma psoriasis UDPglucose 4-epimerase deficiency disease breast carcinoma ductal breast carcinoma in situ interstitial cystitis osteosarcoma galactosemia galactose epimerase deficiency galactokinase deficiency tinea pedis breast cancer dermatophytosis of groin and perianal area intellectual disability malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma psoriasis UDPglucose 4-epimerase deficiency disease breast carcinoma ductal breast carcinoma in situ interstitial cystitis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm tinea corporis inborn errors of metabolism invasive ductal breast carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.