9JTD | pdb_00009jtd

Crystal structure of PCoV-GD receptor binding domain complexed with fox ACE2

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01401	Angiotensin-converting enzyme (Peptidase_M2)	Angiotensin-converting enzyme	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Angiotensin-converting enzyme	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding virus receptor activity exogenous protein binding peptidyl-dipeptidase activity exopeptidase activity transporter activator activity molecular function activator activity molecular function regulator activity peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding virus receptor activity exogenous protein binding peptidyl-dipeptidase activity exopeptidase activity transporter activator activity molecular function activator activity molecular function regulator activity transporter regulator activity carboxypeptidase activity endopeptidase activity cation binding ion binding metal ion binding small molecule binding identical protein binding	heart process multicellular organismal process system process regulation of biological process regulation of cardiac conduction regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction blood circulation heart process multicellular organismal process system process regulation of biological process regulation of cardiac conduction regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction blood circulation regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone regulation of blood volume by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal nervous system process regulation of blood pressure feeding behavior brain renin-angiotensin system behavior regulation of systemic arterial blood pressure endocrine process drinking behavior angiotensin-mediated drinking behavior regulation of biological quality nervous system process involved in regulation of systemic arterial blood pressure regulation of defense response response to stimulus regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus regulation of response to stimulus response to stress regulation of response to stress inflammatory response regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization gap junction assembly positive regulation of biological process cellular component biogenesis cellular component organization cellular component assembly positive regulation of gap junction assembly cell junction assembly cellular component organization or biogenesis positive regulation of cellular process cell-cell junction assembly cell-cell junction organization positive regulation of cellular component biogenesis regulation of gap junction assembly regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process proteolysis protein metabolic process regulation of localization nitrogen compound transport carboxylic acid transmembrane transport regulation of L-proline import across plasma membrane positive regulation of amine transport localization regulation of amino acid transport regulation of proline transport carboxylic acid transport import across plasma membrane L-proline transmembrane transport proline transport establishment of localization organic cation transport organic acid transport transmembrane transport regulation of amino acid import across plasma membrane regulation of transmembrane transport positive regulation of amino acid transport L-alpha-amino acid transmembrane transport amino acid import across plasma membrane proline import across plasma membrane import into cell transport regulation of proline import across plasma membrane positive regulation of L-proline import across plasma membrane amino acid transmembrane transport L-amino acid transport positive regulation of transmembrane transport regulation of amino acid transmembrane transport organic anion transport regulation of transport neutral amino acid transport L-proline import across plasma membrane positive regulation of organic acid transport amino acid transport amine transport proline transmembrane transport positive regulation of transport positive regulation of proline import across plasma membrane regulation of organic acid transport regulation of amine transport virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection cell surface brush border membrane membrane plasma membrane cluster of actin-based cell projections brush border cell periphery apical part of cell membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection cell surface brush border membrane membrane plasma membrane cluster of actin-based cell projections brush border cell periphery apical part of cell plasma membrane region apical plasma membrane cell projection membrane intracellular anatomical structure cytoplasm extracellular region extracellular space
B [auth E]	Spike glycoprotein	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR031588	Collectrin domain	Domain
A	IPR001548	Peptidase M2, peptidyl-dipeptidase A	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.