9KT9 | pdb_00009kt9

Cryo-EM structure of HCA1-Gi complex with 3,5-DHBA

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E [auth R]	Hydroxycarboxylic acid receptor 1	molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation G protein-coupled receptor signaling pathway cellular process signal transduction cell communication negative regulation of catabolic process lipid catabolic process catabolic process regulation of lipid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation G protein-coupled receptor signaling pathway cellular process signal transduction cell communication negative regulation of catabolic process lipid catabolic process catabolic process regulation of lipid metabolic process negative regulation of metabolic process negative regulation of biological process primary metabolic process regulation of catabolic process regulation of lipid catabolic process regulation of primary metabolic process negative regulation of cellular process metabolic process regulation of metabolic process negative regulation of lipid metabolic process negative regulation of lipid catabolic process lipid metabolic process	cell periphery cellular anatomical structure plasma membrane membrane
D [auth E]	scFv16	-	-	-
C	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	protein binding binding G-protein beta-subunit binding	fibroblast proliferation cell population proliferation cellular process cellular response to nitrogen compound cellular response to stimulus response to dopamine regulation of cellular process response to stimulus signaling cellular response to dopamine response to monoamine cell communication response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway fibroblast proliferation cell population proliferation cellular process cellular response to nitrogen compound cellular response to stimulus response to dopamine regulation of cellular process response to stimulus signaling cellular response to dopamine response to monoamine cell communication response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway cellular response to catecholamine stimulus signal transduction regulation of biological process G protein-coupled dopamine receptor signaling pathway biological regulation response to oxygen-containing compound response to nitrogen compound adenylate cyclase-activating G protein-coupled receptor signaling pathway cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to monoamine stimulus response to chemical adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway response to ketone response to prostaglandin response to lipid response to endogenous stimulus response to alcohol cellular response to prostaglandin stimulus cellular response to endogenous stimulus cellular response to prostaglandin E stimulus cellular response to alcohol response to hormone cellular response to lipid response to prostaglandin E cellular response to ketone cellular response to hormone stimulus	cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction
B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein binding binding enzyme binding GTPase binding protein-containing complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity signaling receptor complex adaptor activity protein-macromolecule adaptor activity protein binding binding enzyme binding GTPase binding protein-containing complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity signaling receptor complex adaptor activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity	multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste developmental process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste developmental process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development system development cell population proliferation cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication response to ketone response to prostaglandin response to lipid response to endogenous stimulus response to alcohol cellular response to prostaglandin stimulus response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to prostaglandin E stimulus cellular response to chemical stimulus cellular response to alcohol response to hormone response to chemical cellular response to lipid response to prostaglandin E cellular response to ketone cellular response to hormone stimulus small GTPase-mediated signal transduction Ras protein signal transduction intracellular signal transduction intracellular signaling cassette phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular response to nitrogen compound response to dopamine cellular response to dopamine response to monoamine response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway cellular response to catecholamine stimulus G protein-coupled dopamine receptor signaling pathway response to nitrogen compound adenylate cyclase-activating G protein-coupled receptor signaling pathway cellular response to monoamine stimulus adenylate cyclase-modulating G protein-coupled receptor signaling pathway synaptic signaling cellular response to acetylcholine cell-cell signaling acetylcholine receptor signaling pathway postsynaptic signal transduction G protein-coupled acetylcholine receptor signaling pathway response to acetylcholine	cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex cellular anatomical structure membrane protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cell periphery cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle non-motile cilium 9+0 non-motile cilium cilium neuron projection photoreceptor disc membrane photoreceptor outer segment plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle membrane intracellular anatomical structure cytoplasm cytosol vacuolar membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle lysosomal membrane lysosome synapse cell junction
A	Guanine nucleotide-binding protein G(i) subunit alpha-1	D2 dopamine receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding dopamine receptor binding enzyme regulator activity adenylate cyclase inhibitor activity cyclase regulator activity molecular function inhibitor activity cyclase inhibitor activity molecular function regulator activity enzyme inhibitor activity adenylate cyclase regulator activity D2 dopamine receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding dopamine receptor binding enzyme regulator activity adenylate cyclase inhibitor activity cyclase regulator activity molecular function inhibitor activity cyclase inhibitor activity molecular function regulator activity enzyme inhibitor activity adenylate cyclase regulator activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding magnesium ion binding metal ion binding GDP binding G protein-coupled serotonin receptor binding protein-containing complex binding G-protein beta/gamma-subunit complex binding pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-inhibiting serotonin receptor signaling pathway G protein-coupled serotonin receptor signaling pathway cell communication adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-inhibiting serotonin receptor signaling pathway G protein-coupled serotonin receptor signaling pathway cell communication adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to oxygen-containing compound response to nitrogen compound cell division leukocyte migration immune system process mononuclear cell migration lymphocyte migration cell migration T cell migration cell motility regulation of steroid biosynthetic process regulation of cholesterol biosynthetic process regulation of cholesterol metabolic process steroid metabolic process regulation of lipid metabolic process sterol metabolic process positive regulation of biological process cholesterol metabolic process lipid biosynthetic process alcohol metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of small molecule metabolic process positive regulation of biosynthetic process positive regulation of lipid metabolic process small molecule metabolic process steroid biosynthetic process positive regulation of cellular process regulation of biosynthetic process secondary alcohol biosynthetic process regulation of alcohol biosynthetic process small molecule biosynthetic process regulation of steroid metabolic process cholesterol biosynthetic process positive regulation of cholesterol biosynthetic process primary metabolic process secondary alcohol metabolic process positive regulation of steroid biosynthetic process biosynthetic process sterol biosynthetic process positive regulation of lipid biosynthetic process regulation of sterol biosynthetic process alcohol biosynthetic process positive regulation of cholesterol metabolic process positive regulation of steroid metabolic process metabolic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process regulation of metabolic process positive regulation of alcohol biosynthetic process positive regulation of sterol biosynthetic process lipid metabolic process negative regulation of protein transport regulation of localization establishment of protein localization nitrogen compound transport negative regulation of biological process negative regulation of transport localization negative regulation of secretion negative regulation of hormone secretion negative regulation of secretion by cell intracellular protein localization regulation of biological quality regulation of peptide hormone secretion negative regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region negative regulation of establishment of protein localization protein secretion establishment of localization regulation of protein secretion regulation of secretion negative regulation of protein secretion regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport negative regulation of signaling hormone secretion negative regulation of cell communication protein localization to extracellular region negative regulation of peptide secretion peptide secretion regulation of secretion by cell secretion by cell amide transport signal release negative regulation of cellular process negative regulation of protein localization regulation of signaling regulation of transport secretion regulation of peptide transport regulation of establishment of protein localization export from cell cell-cell signaling regulation of protein transport peptide transport negative regulation of insulin secretion protein transport regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion regulation of cytoskeleton organization regulation of cellular component organization microtubule cytoskeleton organization regulation of mitotic spindle organization mitotic cell cycle cellular component organization cell cycle cellular component organization or biogenesis regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process regulation of cell cycle process regulation of microtubule-based process regulation of spindle organization regulation of organelle organization mitotic spindle organization organelle organization mitotic cell cycle process microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization positive regulation of protein localization to cell periphery protein localization to cell periphery positive regulation of protein localization to cell cortex regulation of protein localization to cell periphery regulation of protein localization to cell cortex positive regulation of protein localization protein localization to cell cortex response to ketone response to prostaglandin response to lipid response to alcohol response to prostaglandin E cellular response to forskolin cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to forskolin cellular response to lipid cellular response to ketone	midbody cellular anatomical structure membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle midbody cellular anatomical structure membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen cell periphery cell cortex cytoplasm protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton centriolar satellite cytosol nucleoplasm vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome Golgi apparatus endomembrane system cilium plasma membrane bounded cell projection ciliary basal body cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth R]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
E [auth R]	IPR051893	Hydroxycarboxylic Acid Receptors	Family
E [auth R]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
C	IPR001770	G-protein, gamma subunit	Family
C	IPR015898	G-protein, gamma subunit-like domain	Domain
C	IPR036284	G-protein gamma-like domain superfamily	Homologous Superfamily
B	IPR019775	WD40 repeat, conserved site	Conserved Site
B	IPR020472	PAC1/LIS1-like, WD-40 repeat	Repeat
B	IPR001632	G-protein beta subunit-like, WD40 repeats	Domain
B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B	IPR016346	G-protein subunit beta 1-5	Family
B	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B	IPR001680	WD40 repeat	Repeat
A	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit	Family
A	IPR011025	G protein alpha subunit, helical insertion	Homologous Superfamily
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR001408	G-protein alpha subunit, group I	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth R]	Pharos: Q9BXC0	breast cancer metabolic syndrome X
C	Pharos: P59768	pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma sarcoidosis ulcerative colitis adrenal cortex carcinoma breast carcinoma Duchenne muscular dystrophy glioblastoma large cell medulloblastoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer Sjogren syndrome X-linked mixed deafness with perilymphatic gusher pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma sarcoidosis ulcerative colitis adrenal cortex carcinoma breast carcinoma Duchenne muscular dystrophy glioblastoma large cell medulloblastoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer Sjogren syndrome X-linked mixed deafness with perilymphatic gusher astrocytic tumor Crohn disease ductal breast carcinoma in situ interstitial cystitis lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma Pick disease primitive neuroectodermal tumor thoracic aortic aneurysm atypical teratoid rhabdoid tumor cystic fibrosis Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma malignant ependymoma osteosarcoma
B	Pharos: P62873	intellectual disability, autosomal dominant 42 melancholia intellectual disability endogenous depression medulloblastoma myopathy ovarian cancer Precursor Cell Lymphoblastic Leukemia Lymphoma anxiety disorder Sjogren syndrome chronic kidney disease juvenile dermatomyositis lung adenocarcinoma neurotic disorder pancreatic ductal adenocarcinoma intellectual disability, autosomal dominant 42 melancholia intellectual disability endogenous depression medulloblastoma myopathy ovarian cancer Precursor Cell Lymphoblastic Leukemia Lymphoma anxiety disorder Sjogren syndrome chronic kidney disease juvenile dermatomyositis lung adenocarcinoma neurotic disorder pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma breast cancer Duchenne muscular dystrophy leukemia, acute lymphocytic, susceptibility to, 1 malignant pancreatic neoplasm myelodysplastic syndrome osteosarcoma plasma cell myeloma rheumatoid arthritis swine influenza childhood acute lymphoblastic leukemia depressive disorder
A	Pharos: P63096	substance withdrawal syndrome dissociative amnesia malignant glioma nicotine dependence pancreatic ductal adenocarcinoma Withdrawal Symptoms acute myeloid leukemia breast cancer glioblastoma intellectual disability large cell medulloblastoma malignant pancreatic neoplasm oligodendroglioma Pick disease astrocytic tumor substance withdrawal syndrome dissociative amnesia malignant glioma nicotine dependence pancreatic ductal adenocarcinoma Withdrawal Symptoms acute myeloid leukemia breast cancer glioblastoma intellectual disability large cell medulloblastoma malignant pancreatic neoplasm oligodendroglioma Pick disease astrocytic tumor breast carcinoma interstitial cystitis malignant colon neoplasm medulloblastoma ovarian cancer subependymal giant cell astrocytoma amnestic disorder atypical teratoid rhabdoid tumor breast fibroadenoma ductal breast carcinoma in situ invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.