9KXV | pdb_00009kxv

Structure of human B0AT1-ACE2 complex with compound3

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00209	Sodium:neurotransmitter symporter family (SNF)	Sodium:neurotransmitter symporter family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Angiotensin-converting enzyme 2	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity metallocarboxypeptidase activity exopeptidase activity metalloexopeptidase activity carboxypeptidase activity endopeptidase activity identical protein binding protein binding binding virus receptor activity peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity metallocarboxypeptidase activity exopeptidase activity metalloexopeptidase activity carboxypeptidase activity endopeptidase activity identical protein binding protein binding binding virus receptor activity exogenous protein binding peptidyl-dipeptidase activity transporter activator activity molecular function activator activity molecular function regulator activity transporter regulator activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	heart process multicellular organismal process system process regulation of biological process regulation of cardiac conduction regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction blood circulation heart process multicellular organismal process system process regulation of biological process regulation of cardiac conduction regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction blood circulation regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone regulation of blood volume by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal nervous system process regulation of blood pressure feeding behavior brain renin-angiotensin system behavior regulation of systemic arterial blood pressure endocrine process drinking behavior angiotensin-mediated drinking behavior regulation of biological quality nervous system process involved in regulation of systemic arterial blood pressure viral process viral life cycle regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization gap junction assembly positive regulation of biological process cellular component biogenesis cellular component organization cellular component assembly positive regulation of gap junction assembly cell junction assembly cellular component organization or biogenesis positive regulation of cellular process cell-cell junction assembly cell-cell junction organization positive regulation of cellular component biogenesis regulation of gap junction assembly regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cellular process biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of tube diameter regulation of tube size regulation of vasoconstriction vascular process in circulatory system blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of signaling negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host viral gene expression viral translation RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process aromatic amino acid transport nitrogen compound transport organic anion transport carboxylic acid transport transport establishment of localization organic cation transport organic acid transport amino acid transport localization tryptophan transport positive regulation of blood circulation positive regulation of cardiac muscle contraction cardiac muscle contraction striated muscle contraction positive regulation of striated muscle contraction regulation of cardiac muscle contraction muscle contraction muscle system process regulation of muscle system process positive regulation of heart contraction regulation of striated muscle contraction regulation of muscle contraction positive regulation of muscle contraction positive regulation of multicellular organismal process peptide hormone processing signaling receptor ligand precursor processing protein maturation proteolysis amide metabolic process protein metabolic process regulation of hormone levels regulation of systemic arterial blood pressure by circulatory renin-angiotensin hormone metabolic process regulation of angiotensin levels in blood protein processing angiotensin maturation membrane organization membrane fusion import into cell receptor-mediated endocytosis of virus by host cell vesicle-mediated transport endocytosis involved in viral entry into host cell receptor-mediated endocytosis endocytosis multi-multicellular organism process maternal process involved in female pregnancy reproductive process multicellular organismal reproductive process female pregnancy multi-organism reproductive process negative regulation of cell population proliferation cell population proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation regulation of cytokine production cytokine production reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of metabolic process regulation of reactive oxygen species metabolic process regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus response to stress regulation of response to stress inflammatory response regulation of localization regulation of transport positive regulation of amine transport amine transport positive regulation of amino acid transport positive regulation of transport regulation of amino acid transport regulation of amine transport carboxylic acid transmembrane transport regulation of L-proline import across plasma membrane regulation of proline transport import across plasma membrane L-proline transmembrane transport proline transport transmembrane transport regulation of amino acid import across plasma membrane regulation of transmembrane transport L-alpha-amino acid transmembrane transport amino acid import across plasma membrane proline import across plasma membrane regulation of proline import across plasma membrane positive regulation of L-proline import across plasma membrane amino acid transmembrane transport L-amino acid transport positive regulation of transmembrane transport regulation of amino acid transmembrane transport neutral amino acid transport L-proline import across plasma membrane positive regulation of organic acid transport proline transmembrane transport positive regulation of proline import across plasma membrane regulation of organic acid transport entry receptor-mediated virion attachment to host cell	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane cytoplasm organelle membrane endocytic vesicle membrane-enclosed lumen endomembrane system intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum cell projection cilium plasma membrane bounded cell projection cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane cell surface membrane microdomain membrane raft brush border membrane cluster of actin-based cell projections brush border cell projection membrane
A	Sodium-dependent neutral amino acid transporter B(0)AT1	amino acid transmembrane transporter activity neutral L-amino acid transmembrane transporter activity transporter activity transmembrane transporter activity active transmembrane transporter activity symporter activity secondary active transmembrane transporter activity	amino acid transport localization transport neutral amino acid transport establishment of localization viral process viral life cycle response to nutrient levels response to stimulus response to chemical response to nutrient monoatomic ion transmembrane transport sodium ion transmembrane transport metal ion transport amino acid transport localization transport neutral amino acid transport establishment of localization viral process viral life cycle response to nutrient levels response to stimulus response to chemical response to nutrient monoatomic ion transmembrane transport sodium ion transmembrane transport metal ion transport monoatomic cation transmembrane transport transmembrane transport monoatomic ion transport cellular process monoatomic cation transport sodium ion transport	cell periphery cellular anatomical structure apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cellular anatomical structure apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle brush border membrane cluster of actin-based cell projections plasma membrane bounded cell projection brush border cell projection cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR031588	Collectrin domain	Domain
B	IPR001548	Peptidase M2, peptidyl-dipeptidase A	Family
A	IPR000175	Sodium:neurotransmitter symporter	Family
A	IPR002438	Neutral amino acid SLC6 transporter	Family
A	IPR037272	Sodium:neurotransmitter symporter superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q9BYF1	endomyocardial fibrosis hypertensive disorder abdominal aortic aneurysm inborn carbohydrate metabolic disorder kidney disease Middle East respiratory syndrome obesity disorder adult acute respiratory distress syndrome pulmonary edema common cold Spontaneous abortion COVID-19–associated multisystem inflammatory syndrome in children ulcerative colitis cystic fibrosis heart disease endomyocardial fibrosis hypertensive disorder abdominal aortic aneurysm inborn carbohydrate metabolic disorder kidney disease Middle East respiratory syndrome obesity disorder adult acute respiratory distress syndrome pulmonary edema common cold Spontaneous abortion COVID-19–associated multisystem inflammatory syndrome in children ulcerative colitis cystic fibrosis heart disease influenza nephrosclerosis pneumonia cerebrovascular disorder pulmonary embolism coronary artery disease thrombotic disease Crohn disease diabetes mellitus diarrheal disease Ebola hemorrhagic fever intellectual disability lymphopenia psoriasis chronic obstructive pulmonary disease severe acute respiratory syndrome COVID-19 transitional cell carcinoma cutaneous lupus erythematosus diabetic kidney disease disseminated intravascular coagulation
A	Pharos: Q695T7	Hartnup disease iminoglycinuria hyperglycinuria melanoma osteosarcoma prostate carcinoma testicular cancer atypical teratoid rhabdoid tumor brain glioma colorectal cancer estrogen-receptor negative breast cancer lung adenocarcinoma nasopharyngeal disease ovarian cancer skin basal cell carcinoma Hartnup disease iminoglycinuria hyperglycinuria melanoma osteosarcoma prostate carcinoma testicular cancer atypical teratoid rhabdoid tumor brain glioma colorectal cancer estrogen-receptor negative breast cancer lung adenocarcinoma nasopharyngeal disease ovarian cancer skin basal cell carcinoma testicular germ cell tumor B-cell chronic lymphocytic leukemia breast carcinoma cutaneous melanoma exocrine pancreatic carcinoma intellectual disability lung carcinoma non-small cell lung carcinoma ovarian carcinoma systemic lupus erythematosus uterine corpus leiomyoma benign prostatic hyperplasia colorectal adenoma Epileptic encephalopathy glioblastoma idiopathic pulmonary fibrosis large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.