9NAD | pdb_00009nad

Human GSTO1-1 complexed with C5-1

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Glutathione S-transferase omega-1	oxidoreductase activity catalytic activity oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor methylarsonate reductase activity oxidoreductase activity, acting on phosphorus or arsenic in donors glutathione transferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups oxidoreductase activity, acting on a sulfur group of donors disulfide oxidoreductase activity antioxidant activity glutathione disulfide oxidoreductase activity glutathione dehydrogenase (ascorbate) activity oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	regulation of calcium ion transport regulation of localization regulation of cellular process transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of biological process negative regulation of transport regulation of monoatomic ion transmembrane transport calcium ion transport metal ion transport negative regulation of transmembrane transport regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport localization regulation of calcium ion transport regulation of localization regulation of cellular process transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of biological process negative regulation of transport regulation of monoatomic ion transmembrane transport calcium ion transport metal ion transport negative regulation of transmembrane transport regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport localization negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol negative regulation of cellular process monoatomic ion transport negative regulation of cation transmembrane transport monoatomic cation transport regulation of metal ion transport regulation of biological process calcium ion transmembrane import into cytosol regulation of transport regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport biological regulation establishment of localization negative regulation of calcium ion transport transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport cellular process regulation of monoatomic cation transmembrane transport negative regulation of calcium ion transmembrane transport calcium ion transmembrane transport cellular response to stimulus multicellular organismal process system process response to stimulus regulation of system process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum intracellular signal transduction cell communication multicellular organismal movement regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion positive regulation of striated muscle contraction intracellular signaling cassette signal transduction regulation of skeletal muscle contraction by calcium ion signaling release of sequestered calcium ion into cytosol by endoplasmic reticulum positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion skeletal muscle contraction muscle contraction regulation of striated muscle contraction regulation of muscle contraction calcium-mediated signaling positive regulation of muscle contraction positive regulation of multicellular organismal process signaling positive regulation of biological process striated muscle contraction musculoskeletal movement regulation of skeletal muscle contraction regulation of multicellular organismal process nervous system process neuromuscular process muscle system process regulation of muscle system process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum monosaccharide metabolic process carbohydrate metabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process L-ascorbic acid metabolic process lactone metabolic process metabolic process small molecule metabolic process glutathione metabolic process modified amino acid metabolic process sulfur compound metabolic process catabolic process cellular response to xenobiotic stimulus xenobiotic catabolic process xenobiotic metabolic process response to xenobiotic stimulus cellular response to chemical stimulus response to chemical cellular response to arsenic-containing substance response to arsenic-containing substance regulation of heart contraction cardiac muscle contraction circulatory system process regulation of cardiac muscle contraction regulation of blood circulation heart process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion blood circulation regulation of cardiac muscle contraction by calcium ion signaling heart contraction positive regulation of cation transmembrane transport positive regulation of calcium ion transport positive regulation of monoatomic ion transport positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport positive regulation of monoatomic ion transmembrane transport positive regulation of release of sequestered calcium ion into cytosol positive regulation of cellular process positive regulation of transport	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004046	Glutathione S-transferase, C-terminal	Domain
A	IPR010987	Glutathione S-transferase, C-terminal-like	Domain
A	IPR004045	Glutathione S-transferase, N-terminal	Domain
A	IPR045073	Glutathione S-transferase Omega/Tau-like	Family
A	IPR050983	Glutathione S-transferase Omega/HSP26	Family
A	IPR036282	Glutathione S-transferase, C-terminal domain superfamily	Homologous Superfamily
A	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
A	IPR005442	Glutathione S-transferase, omega-class	Family
A	IPR040079	Glutathione transferase family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P78417	esophageal squamous cell carcinoma plasma cell myeloma prostate cancer cancer leukemia ovarian cancer precancerous condition Prostatic Neoplasms tuberculosis astrocytic tumor lung cancer lymphoplasmacytic lymphoma neurodegenerative disease pancreatic ductal adenocarcinoma benign neoplasm esophageal squamous cell carcinoma plasma cell myeloma prostate cancer cancer leukemia ovarian cancer precancerous condition Prostatic Neoplasms tuberculosis astrocytic tumor lung cancer lymphoplasmacytic lymphoma neurodegenerative disease pancreatic ductal adenocarcinoma benign neoplasm cystic fibrosis large cell medulloblastoma lung disease medulloblastoma skin disease drug-induced liver injury

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.