Annotations: 9PI9

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E, F	Tumor-associated calcium signal transducer 2	-	multicellular organismal process negative regulation of locomotion regulation of cell motility regulation of cellular process negative regulation of biological process tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration regulation of cell migration negative regulation of cellular process regulation of multicellular organismal process cell migration epithelial cell migration cell motility multicellular organismal process negative regulation of locomotion regulation of cell motility regulation of cellular process negative regulation of biological process tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration regulation of cell migration negative regulation of cellular process regulation of multicellular organismal process cell migration epithelial cell migration cell motility regulation of epithelial cell migration locomotion negative regulation of cell migration regulation of biological process biological regulation epithelium migration regulation of locomotion negative regulation of cell motility cellular process negative regulation of multicellular organismal process developmental process cellular developmental process regulation of developmental process positive regulation of biological process regulation of cell differentiation positive regulation of developmental process positive regulation of stem cell differentiation stem cell differentiation positive regulation of cell differentiation cell differentiation regulation of stem cell differentiation positive regulation of cellular process cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation mesonephric epithelium development kidney epithelium development nephron morphogenesis nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis multicellular organism development tube morphogenesis anatomical structure development renal tubule development animal organ morphogenesis epithelial tube morphogenesis nephron development system development nephron epithelium development ureteric bud development epithelium development mesonephros development tube development animal organ development morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process regulation of actin filament bundle assembly cellular component biogenesis cellular component organization cellular component assembly actin filament bundle organization actin filament-based process cellular component organization or biogenesis stress fiber assembly negative regulation of supramolecular fiber organization regulation of actin filament organization negative regulation of stress fiber assembly actin cytoskeleton organization actomyosin structure organization negative regulation of cellular component organization negative regulation of cytoskeleton organization actin filament organization regulation of cellular component biogenesis negative regulation of actin filament bundle assembly regulation of organelle organization regulation of stress fiber assembly organelle organization negative regulation of organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization regulation of actin cytoskeleton organization actin filament bundle assembly regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization sensory perception of light stimulus system process sensory perception nervous system process visual perception regulation of cell-substrate adhesion regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading cell-substrate adhesion negative regulation of cell adhesion cell adhesion negative regulation of substrate adhesion-dependent cell spreading substrate adhesion-dependent cell spreading negative regulation of cell-substrate adhesion ruffle organization cell projection organization plasma membrane bounded cell projection assembly negative regulation of ruffle assembly ruffle assembly negative regulation of plasma membrane bounded cell projection assembly negative regulation of cell projection organization plasma membrane bounded cell projection organization regulation of cell projection organization regulation of cell projection assembly regulation of plasma membrane bounded cell projection assembly regulation of ruffle assembly cell projection assembly regulation of plasma membrane bounded cell projection organization branching morphogenesis of an epithelial tube regulation of kidney development regulation of branching involved in ureteric bud morphogenesis negative regulation of branching involved in ureteric bud morphogenesis regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis branching involved in ureteric bud morphogenesis regulation of morphogenesis of an epithelium regulation of anatomical structure morphogenesis negative regulation of developmental process morphogenesis of a branching structure negative regulation of morphogenesis of an epithelium morphogenesis of a branching epithelium	cellular anatomical structure membrane cell periphery basal part of cell plasma membrane basal plasma membrane plasma membrane region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical structure membrane cell periphery basal part of cell plasma membrane basal plasma membrane plasma membrane region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol lateral plasma membrane intracellular organelle nucleus intracellular membrane-bounded organelle
B, D	Sacituzumab Light Chain	-	-	-
A, C	Sacituzumab Heavy Chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E, F	IPR043406	Transmembrane glycoprotein EPCAM/Trop-2	Family
E, F	IPR049420	EPCAM/Trop-2, C-terminal	Domain
E, F	IPR041630	Epithelial cell adhesion molecule N-terminal domain	Domain
E, F	IPR036857	Thyroglobulin type-1 superfamily	Homologous Superfamily
E, F	IPR000716	Thyroglobulin type-1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E, F	Pharos: P09758	gelatinous drop-like corneal dystrophy amyloidosis endometriosis pancreatic intraductal papillary-mucinous neoplasm Triple negative breast neoplasms corneal dystrophy ductal breast carcinoma in situ lung carcinoma nasopharyngeal carcinoma pancreatic ductal adenocarcinoma pulmonary hypertension tuberculosis acquired metabolic disease Crohn disease interstitial cystitis gelatinous drop-like corneal dystrophy amyloidosis endometriosis pancreatic intraductal papillary-mucinous neoplasm Triple negative breast neoplasms corneal dystrophy ductal breast carcinoma in situ lung carcinoma nasopharyngeal carcinoma pancreatic ductal adenocarcinoma pulmonary hypertension tuberculosis acquired metabolic disease Crohn disease interstitial cystitis malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma spina bifida ulcerative colitis cystic fibrosis lung cancer MALT lymphoma ovarian cancer

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
E, F	PCA	Parent Component: GLN RESID: AA0031 PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.