9THQ | pdb_00009thq

Crystal structure of the human serum transferrin with Fe(III) bound at the C-lobe only

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA]	PF00405	Transferrin (Transferrin)	Transferrin		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA]	Serotransferrin	cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding ferric iron binding transferrin receptor binding protein binding signaling receptor binding metallochaperone activity iron chaperone activity cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding ferric iron binding transferrin receptor binding protein binding signaling receptor binding metallochaperone activity iron chaperone activity molecular carrier activity transmembrane transporter binding enzyme binding	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis localization transport iron ion transport transition metal ion transport intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis localization transport iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport cellular response to stimulus cellular response to iron ion cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to iron ion response to chemical cellular process humoral immune response biological process involved in interspecies interaction between organisms response to other organism defense response immune response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress immune system process response to bacterium response to external biotic stimulus multicellular organismal-level iron ion homeostasis multicellular organismal process multicellular organismal-level homeostasis multicellular organismal-level chemical homeostasis positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process metabolic process ubiquitin-dependent protein catabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process regulation of protein stability regulation of biological quality cell surface receptor signaling pathway signaling signal transduction cell communication regulation of localization import into cell positive regulation of cellular component organization regulation of cellular component organization vesicle-mediated transport cellular component organization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of transport endocytosis receptor-mediated endocytosis developmental process myeloid leukocyte differentiation cellular developmental process hemopoiesis cell development myeloid cell differentiation cell differentiation osteoclast differentiation anatomical structure development leukocyte differentiation	cellular anatomical structure clathrin-coated pit membrane endomembrane system membrane-bounded organelle organelle vesicle cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane basal part of cell basal plasma membrane cellular anatomical structure clathrin-coated pit membrane endomembrane system membrane-bounded organelle organelle vesicle cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane basal part of cell basal plasma membrane intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane cytoplasm organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex HFE-transferrin receptor complex receptor complex cell surface early endosome endosome blood microparticle membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum recycling endosome vesicle lumen cytoplasmic vesicle lumen secretory granule lumen secretory granule secretory vesicle perinuclear region of cytoplasm endosome membrane late endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA]	IPR016357	Transferrin	Family
A [auth AAA]	IPR001156	Transferrin-like domain	Domain
A [auth AAA]	IPR018195	Transferrin family, iron binding site	Binding Site
A [auth AAA]	IPR030685	Serotransferrin, mammalian	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA]	Pharos: P02787	atransferrinemia Alzheimer disease echinococcosis nephrotic syndrome hypochromic microcytic anemia obesity disorder alcohol abuse restless legs syndrome Inflammation malignant mesothelioma sarcomatoid carcinoma carcinoma paratuberculosis hepatitis breast cancer atransferrinemia Alzheimer disease echinococcosis nephrotic syndrome hypochromic microcytic anemia obesity disorder alcohol abuse restless legs syndrome Inflammation malignant mesothelioma sarcomatoid carcinoma carcinoma paratuberculosis hepatitis breast cancer malignant glioma cystic fibrosis medulloblastoma ductal breast carcinoma in situ pancreatic intraductal papillary-mucinous carcinoma Pick disease glioblastoma primitive neuroectodermal tumor schizophrenia subependymal giant cell astrocytoma atopic eczema autism lung cancer breast carcinoma mammary neoplasms, animal drug-induced liver injury oligodendroglioma acute kidney failure pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer hemochromatosis type 1 progressive supranuclear palsy sinusitis invasive ductal breast carcinoma large cell medulloblastoma malignant ependymoma malignant pancreatic neoplasm osteosarcoma esophageal adenocarcinoma fatty liver disease psoriasis schizoaffective disorder undifferentiated carcinoma atypical teratoid rhabdoid tumor lung adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.