0QB

(2S)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-{(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-2-[(3R)-1,5,5-trimethyl-2-oxopyrrolidin-3-yl]ethyl}-N~4~-[2-(dimethylamino)-2-oxoethyl]-N~4~-[(1S)-1-phenylethyl]butanediamide

Created:2008-11-12
Last modified:  2021-03-01

Chemical Details

Formal Charge0
Atom Count102
Chiral Atom Count5
Bond Count105
Aromatic Bond Count11
2D diagram of 0QB
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Chemical Component Summary

Name(2S)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-{(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-2-[(3R)-1,5,5-trimethyl-2-oxopyrrolidin-3-yl]ethyl}-N~4~-[2-(dimethylamino)-2-oxoethyl]-N~4~-[(1S)-1-phenylethyl]butanediamide
SynonymsP2-P3 butanediamide renin inhibitor (3)
Systematic Name (OpenEye OEToolkits)(2R)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N-[(1S,2S)-3-cyclohexyl-1-hydroxy-1-[(3R)-1,5,5-trimethyl-2-oxo-pyrrolidin-3-yl]propan-2-yl]-N'-(2-dimethylamino-2-oxo-ethyl)-N'-[(1S)-1-phenylethyl]butanediamide
FormulaC36 H54 N6 O5 S
Molecular Weight682.916
TypeNON-POLYMER

Chemical Descriptors

TypeProgramVersionDescriptor
SMILESACDLabs10.04O=C1N(C)C(C)(C)CC1C(O)C(NC(=O)C(Cc2nc(sc2)N)CC(=O)N(CC(=O)N(C)C)C(c3ccccc3)C)CC4CCCCC4
SMILESCACTVS3.352C[CH](N(CC(=O)N(C)C)C(=O)C[CH](Cc1csc(N)n1)C(=O)N[CH](CC2CCCCC2)[CH](O)[CH]3CC(C)(C)N(C)C3=O)c4ccccc4
Canonical SMILESCACTVS3.352 C[C@H](N(CC(=O)N(C)C)C(=O)C[C@@H](Cc1csc(N)n1)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)[C@@H]3CC(C)(C)N(C)C3=O)c4ccccc4
InChIInChI1.03 InChI=1S/C36H54N6O5S/c1-23(25-15-11-8-12-16-25)42(21-31(44)40(4)5)30(43)19-26(18-27-22-48-35(37)38-27)33(46)39-29(17-24-13-9-7-10-14-24)32(45)28-20-36(2,3)41(6)34(28)47/h8,11-12,15-16,22-24,26,28-29,32,45H,7,9-10,13-14,17-21H2,1-6H3,(H2,37,38)(H,39,46)/t23-,26+,28-,29-,32-/m0/s1
InChIKeyInChI1.03 IFJSAOFSWZWPQF-SQMKVVGDSA-N

Related Resource References

Resource NameReference
PubChem 6323286