4DY

(6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide

Created:	2015-04-30
Last modified:	2020-05-26

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7 entries where 4DY is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	49
Chiral Atom Count	0
Bond Count	49
Aromatic Bond Count	6

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Chemical Component Summary
Name	(6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
Synonyms	Capsaicin; 8-Methyl-N-vanillyl-trans-6-nonenamide; NGX-4010
Systematic Name (OpenEye OEToolkits)	(E)-N-[(3-methoxy-4-oxidanyl-phenyl)methyl]-8-methyl-non-6-enamide
Formula	C₁₈ H₂₇ N O₃
Molecular Weight	305.412
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	c1(CNC(CCCC[C@H]=CC(C)C)=O)cc(OC)c(cc1)O
SMILES	CACTVS	3.385	COc1cc(CNC(=O)CCCCC=CC(C)C)ccc1O
SMILES	OpenEye OEToolkits	1.7.6	CC(C)C=CCCCCC(=O)NCc1ccc(c(c1)OC)O
Canonical SMILES	CACTVS	3.385	COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O
Canonical SMILES	OpenEye OEToolkits	1.7.6	CC(C)/C=C/CCCCC(=O)NCc1ccc(c(c1)OC)O
InChI	InChI	1.03	InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChIKey	InChI	1.03	YKPUWZUDDOIDPM-SOFGYWHQSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB06774
Name	Capsaicin
Groups	approved
Description	Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
Synonyms	trans-8-Methyl-N-vanillyl-6-nonenamide Isodecenoic acid vanillylamide Capsaicin (E)-8-Methyl-N-vanillyl-6-nonenamide Capsaicina
Brand Names	Rock Sauce Preferred Plus Arthritis Cream Genorthix Pain Relieving Roll On Capsaicin Regular Cream Diclopak Ameri Patch MedWorx Zostrix Hot and Cold Therapy System Fesi Menthozen Hydrogel Zostrix Original Strength Ziclocin Meijer Capsaicin Perform Atomic Heat Walgreens Capsaicin Hot Levatio Patch Emu Essentials Brand Pain Relieving Nexalgia NuDroxiPAK N-500 Pain Relief Roll On Pain Relief Cream Extra Strength PainMD Max Capsaicin Forte Cream CVS Medicated Heat 1 ct Complete hemp Dusel Warm Arthritis Dead Sea Salt Therapy Antiphlogistine Rub A-535 Capsaicin Liquid LCDO. ORLANDO RIVERA ARTHRITIS Topical Analgesic Awaye Dr Iyers MyoRub Nuvira Patch Capsodan Cream Renovo Lido5 CVS Capsaicin RETADOLOR Pain Relief Anodynz Medi-sulting Topical Pain Relief Reliever Doloracin/l Rx With Lidocaine Capsaicin Arthritis Pain Relief Cream Rite Aid Capsicum Hot Satogesic Hot Hot Pain Relief Capsaicin Mild Cream Mac Megrix OTC Cajun Hot Ice Muscle and Joint Pain Rub PainKoolers Topical Analgesic Patch Menthol, Capsaicin Walgreens Arthritis Pain Relief Capsaicin Analgesic Soothe Aspercreme Warming Patch Good Neighbor Pharmacy Arthritis Pain Relief Dyninex Hot spot point relief Omega 3 Medrox-Rx Melt Pain Away Capsicum Patch Xyphex Biofrequency Chip Equate Capsaicin Pain Relieving Pain Relieving Roll-On Invisible Pain FYZICAL SPORTS Pain Relief 2 MILD New Terocin Capzasin No Mess Applicator Zostrix Foot Pain Relief Minted Leaf Heat Therapy Relief Roll-On Parche Leon Rematex Trubrexa Coralite Pain Relief NuDroxiPAK DSDR-50 ZENSEZONE Arthmed Temporary Pain Relief Cream CopperFixx Miracle Plus Overnight Pain Relieving CMX Topical Pain Mendex Nufabrx Back Wrap Sure Relief SR Relief LABOFLEX Cool and Hot Menthol 1.25 percent Capsaicin 0.025 percent Medicated Pain Relief Hot Pallerix Tianhe Gutong Tiegao (in Polyisobutylene Carrier) Migryl Red hot Penetrex(r) Arthritis Pain Relief A2a Arthritis Menthocin Patch with Lidocaine Outdoor Hands Remaxazon External Patch Offense Player Arthritis Pain BRONSON SOOTHE Pain Relief DFS 75mg DR/MS 25%/MENTH 6%/CAP 0.025% PAK Castiva Warming Menthacin - Cream Theragen HP DCH Arthritis Pain Relief Roll-On Zang Hong Hua Pain Relieving NaproPax FlexePax Nufabrx Compression Sock NuDroxicin pain relief Roll-On Sinelee Inavix Medi-derm / L With Lidocaine Capsaicin Heat Menthozen Hydrogel Patch Topical Pain Relief Rx beeRX Muscle and Joint Pain Relief Pain Relief Frankie Avalons ZERO PAIN Original Formula Roll-On Maximum Strength PAIN RELIEVER KASEHA Pain Relieving Gel EMU THERAPY Red Hot Pepper Pain Relief Cream Born Again Super Pain Relieving Lotion Nufabrx Grey Polka Dot Sock Wasabi Rub Qutenza Capsaicin Cream 0.025% Coralite Topical Analgesic Capsaicin Heat Pure Relief Penetrating Pain Relief Alegenix Biofrequency Chip Flanax Liniment Unit Dose Display Arth Arrest AVON HeXashield Arthritis Pain Relief Cream Capsaisin Australian Dream Power 4 Muscle and Joint Pain Relief Cream Capsaicin Jupiter Pain Patch Sure Result DSS Premium Pak Renovo Terphouse Raging Kakapo Pain Relieve Bio-Sorb Assured Pain Relief Hot Menthol VANTELIN HOT PAIN RELIEVING Gel Patch Nufabrx Medicine Infused Socks Capsaicin Heat Patches Back and Large Areas Sherman and Clark Pain Relieving Kapsin Nufabrx Medicine Infused Ankle Sleeve Menthozen LBri Super Aloe Stop The Pain Transderm-IQ MediRelief Hot Kapzin DC Iclofenac CP InstaSoothe Pain Relief DicloHeal-60 External Analgesic Corisin Arthritis Pain Relief Therapatch Warm Pain Away Astrapharm Chilli Brand External Medicated MenCaps Synovium Pain Relieving Gel Arthritazin Pain Relieving Ziks Arthritis Pain Relief MaC Patch Releevia Xoten-C Red Hot PainKoolers Good Neighbor Pharmacy Capsaicin Trubrexa Patch ER Flanax Capsaicin Cream 1st Medxpatch With Lidocaine 4% Kapsin External Analgesic Migryl Biofrequency Chip Capsinac Arthritis Extra Strength Roll-ON Lotion Nufabrx Lower Leg Sleeve Arthritis Pain Relief Capsaicin Pain Relief Leader Capsaicin Pain Relief Cream Alivio Medicated Compression Sock NaproxenPax Blue Ice Pain Relieving CyclobenzaprinePax Dr. Harveys Herbal Motion Pain Formula HURT BLOCKER PRO Pain Relief Capsiderm Nufabrx Lower Leg Sleeve XS/S AnodyneRx Wellness Products VictoRx Capzasin P Arthritis Pain Relief FYZICAL SPORTS Pain Relief 1-COOL Guardania Pain Rocksauce Fire Menthacin Lotion Medi-derm Rx K2c IRxAmigra Pain Relieving Gel-Patch Kool Heat Pain Therapy Aleveer Patch Rezil Toplast Cool and Hot Menthol 5percent plus Capsaicin 0.025percent NuDroxiPAK Nufabrx Ankle Sleeve Sinsinpas Hot Capzasin-P Creme - 0.025% Arthricare for Women Extra Moisturizing Zostrix Foot Pain Relief Maximum Strength Astronic FourPainRX Muscular Balm Diclofex DC Eagle My Omega Heat Therapy Flexin NuDroxiPAK M-15 Allevess Capzasin HP Arthritis Pain Relief Antiphlogistine Rub A-535 Capsaicin Gel CANNABIN PLUS Warming Pain Relief Parche Leon Milagroso Reme D Medicated Heat Reliaderm NuDiclo TabPak Arthricare for Women Multi-action Hot Spot Point Relief Therapy Pain Exoten-C Pure Relief IRxMyoRub Nopiate Topical Pain Relief Pain Relief Hot Patch CareALL Arthritis and Muscle SprayPain Away Pallerix OTC BIOfrequency Chip N-LABS SOLAR MAX Topical Analgesic Tianhe Zhuifeng Gao Zostrix Hp Anodynz Biofrequency Chip Nufabrx Diabetic Sock Releevia MC Flexipak Satohap Cool and Hot Pads Rugby Capsaicin External Analgesic Arthmed Topical Analgesic Parche Leon Milagroso Dual Action NuDroxiPAK I-800 FlexxSonic Pain Relief NobleAid CapsAid Capsimide Hot Pain Relieving Campo pharma Muscle hot Extra Strength Pain Reliever Topical Pain Relief Alivio Medicated Pain BioMega Heat Pain Therapy Mega Patch CVS Capsaicin arthritis pain relief Transanosil Neurodexx Rugby Arthritis Pain Relieving Topical Analgesic Ultracin QC Arthritis Pain Relief Nufabrx Calf Sleeve Equi-block Dt Formula Cvs Capsaicin Fatazen Sweat Enhance Hot LexiCaps Terocin Capzix Solaice Joint Maintenance Compliance Kit Screamin Hot Toast Doloracin Rx Coralite Pain Relief Hot Dr.'s Cream WellPatch Warming Pain Relief Rub A535 Capsaicin Fors Pain Relief Nufabrx Foot/Ankle Sleeve Soothanol X2 Overtime-HMP Neuriterx 0.05% True Pain Relief Plus Rugby Capsaicin Cream DINGTAI PHARMATopical Analgesic Diclovix CM NuDiclo SoluPak Gellert Joint Care Neuvaxin Patch Trans-D Hurt Blocker Pro AthletesGel LivRelief Pain Relief Family Care Arthritis Pain Relief Chill Pain Away Astrapharm Chilli Brand Oprava Menthozen Cream Cannavera Pain Relief Dolor-parche With Lidocaine-RX Med O-3 Bio- Paraid Hot Capsicum Leader Capsaicin Pain Relieving Adazin Aspercreme Warming NuDroxiPAK DSDR-75 Transderm-iQ Ultra Therapy Pain Relief Ziclopro CapsFenac Pak Douleurin Topical Pain Relief Benejoint Pure Pain Relief WellPatch Capsaicin Pain Relief CMC Pain Relieving Kentwool SensationWool with Nufabrx RockSauce FIERY HOT PAIN RELIEF Nufabrx Lower Leg Sleeve XL/XXL Bioaches Mentholatum Ironman Arthritic Pain Relief Nufabrx Wrist Sleeve Pennsaicin Medrox Toplast Hot Capsaicin 0.025percent Capsaicin No-Fuss Applicator Medi-patch With Lidocaine Rx Dr Demand Relief Pain Relief PainKoolers Topical Analgesic Limencin FYZICAL SPORTS Pain Relief Glacierix Coralite Muscle and Joint Pain Relief Simanix Kanjo Natural Pain relief oil Better Nature Pain Relief Cream PainBloc Sure Result SR Relief Qroxin Patch Silvera Pain Relief Patch Family Care Thera Flex Pain AmeriPatch LaBella Linimento Obrero Frankie Avalons Zero Pain Roll On Rotex Capsaicin Hot Patches Coralite Medicated Heat NuDroxiPAK E-400 Earths Care Arthritis Nufabrx Lower Leg Sleeve M/L Omega 3 Heat Therapy Flex-OL Arthritazin Pain Relieving EZ Wellness Products J-FLEX Yunnan Baiyao Arthritis Pain Relief NuDroxicin Arthritis Pain Reliever 1st Medxpatch With Lidocaine 4%-rx Arthricare for Women Quick Drying Aspercreme Warming No Mess LidoPro Dfs 1.5%/ms 25%/menth 6%/cap 0.025% Pak Menthocin Patch with Lidocaine - Strong Diclosaicin Overtime-X MINTED LEAF Heat Therapy Roll-On with Capsaicin and CBD CareOne Arthritis Pain Relief Diclosiacin Good Neighbor Capsaicin Heat Patch for Back bB Medicated Pain Relieving Oil LaboFlex Cool and Hot Menthol 1.25 percent Capsaicin 0.025 percent Offense Player Sports SmartRx Gaba-V Kit Toplast Cool and Hot Menthol 1.25percent plus Capsaicin 0.025percent Kerasal NeuroCream Sinsinpas Hot Large Dr. OH BALM Tianhe Gutong Tiegao Medi-derm Topical Pain Relief Ultimate Topical Pain Relief Patch 2-Count HEAT PATCHES Pain Relief Patch Assured Pain Relief Hot Patch Capzasin Quick Relief Capsaicin Heat Patches Pain Relief Aflexeryl-MC Compression Sock Neuritrx LONOL Forte Gel VitaCin MINTED LEAF Heat Therapy Relief Roll On Arth RX Topical Analgesic Zostrix High Potency Foot Pain Relief Arthur Itis Cream Nufabrx Hand/Wrist Sleeve Capsaicin Topical Analgesic Capsaicin HP Arthritis Pain Relief Miracle Plus Neck and Shoulder Pain Relief Capment PureKana Nufabrx Ankle Sock Ultra Strength Pain Relief Moor Balm - Crm Captracin Kessler Family Wellness Heet Liniment Liq Overtime Lido-RX 4.1 BLUE SPRING Foot and Leg Comfort Cream with Pain Relief Neuriterx Weh-Weh Natural Pain relief oil Solstice Capsaicin Patch Hot Better Nature Pain Relief BalmX Menthol 4.5% Capsaicin 0.0225% Nufabrx Neck Wrap VANTELIN HOT PAIN RELIEVING Gel Patch Large Nuvira Littles All Natural Arthritic Pain Relief Megrix Overtime-hmp Capsaicin External Analgesic BioMega SumaChip Painazin CP Nufabrx Arm Sleeve DICLAREAL TOPICAL kit Dendracin Neurodendraxcin Rocksauce Ice Apanol Linimento Obrero Moisturizing Glucosamine Brand Soothee Patch Atomic Balm CVS Roll-On Flanax Liniment Theragen Capxib Lidopro Capsaicin 0.1 Percent Nufabrx Knee Sleeve Power Pain Relief Stick PainBloc24 Capsaicin 0.075 Percent Hong Hoa Pain Relieving Triple Action Arthritis Zostrix Diabetic Joint and Arthritis Pain Relief Medi-derm / L With Lidocaine Rx Ageranium Patch Zostrix Joint and Arthritis Pain Relief Fast Arthritis Aid Pain Relieving Medi-patch With Lidocaine Toplast Cool and Hot Menthol 4percent plus Capsaicin 0.025percent Hempvana Ultra Strength Pain Relief Cream - Deep Heat Revlex Arthritis Pain Relief BIO-MEGA Heat Therapy Relyyt
Indication	The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.
Categories	Alkaloids Alkenes Amides Analgesics Anesthetics Anesthetics, Local Antipruritics Basic Lotions and Liniments Benzene Derivatives Capsaicin and Similar Agents Cholinesterase Inhibitors Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Lipids Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Peripheral Nervous System Agents Phenols Polyunsaturated Alkamides Sensory System Agents Solanaceous Alkaloids Topical Products for Joint and Muscular Pain TRPV1 Channel Agonists
ATC-Code	M02AB01 N01BX04
CAS number	404-86-4

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Transient receptor potential cation channel subfamily V member 1	MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLF...	unknown	agonist,regulator
Prohibitin-2	MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAI...	unknown
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	inhibitor
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Myeloperoxidase	MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAA...	unknown	inhibitor
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	substrate,inducer
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	substrate
Amine oxidase [flavin-containing] A	MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGG...	unknown	inhibitor
Dopamine beta-hydroxylase	MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYH...	unknown	inhibitor
Glutamine synthetase	MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSE...	unknown	inducer
Cholinesterase	MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFG...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682