6LH

4-(aminomethyl)benzene-1-sulfonamide

Created:2016-05-02
Last modified:  2017-05-03

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Chemical Details

Formal Charge0
Atom Count22
Chiral Atom Count0
Bond Count22
Aromatic Bond Count6
2D diagram of 6LH

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Chemical Component Summary

Name4-(aminomethyl)benzene-1-sulfonamide
Systematic Name (OpenEye OEToolkits)4-(aminomethyl)benzenesulfonamide
FormulaC7 H10 N2 O2 S
Molecular Weight186.231
TypeNON-POLYMER

Chemical Descriptors

TypeProgramVersionDescriptor
SMILESACDLabs12.01S(c1ccc(CN)cc1)(=O)(N)=O
SMILESCACTVS3.385NCc1ccc(cc1)[S](N)(=O)=O
SMILESOpenEye OEToolkits2.0.4c1cc(ccc1CN)S(=O)(=O)N
Canonical SMILESCACTVS3.385 NCc1ccc(cc1)[S](N)(=O)=O
Canonical SMILESOpenEye OEToolkits2.0.4 c1cc(ccc1CN)S(=O)(=O)N
InChIInChI1.03 InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)
InChIKeyInChI1.03 TYMRLRRVMHJFTF-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License
DrugBank IDDB06795 
NameMafenide
Groups
  • withdrawn
  • approved
  • vet_approved
DescriptionMafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.[L36773] In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA due to an unresolved confirmatory study required to fulfill the accelerated approval requirements.[L44251]
Synonyms
  • 4-Homosufanilamide
  • Mafenide
  • Bensulfamide
  • Mafenide Acetate
  • Maphenidum
Brand Names
  • Sulfamylon Cream - 8.5%
  • Sulfamylon
  • Mafenide acetate
  • Mafenide Acetate
IndicationIndicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.[label]
Categories
  • Amides
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Benzene Derivatives
ATC-Code
  • G01AE10
  • D06BA03
CAS number138-39-6

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License
NameTarget SequencePharmacological ActionActions
Carbonic anhydrase 2MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVS...unknowninhibitor
Carbonic anhydrase 12MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSC...unknowninhibitor
Carbonic anhydrase 14MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDI...unknowninhibitor
Carbonic anhydrase 4MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDR...unknowninhibitor
Carbonic anhydrase 6MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPI...unknownantagonist
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL419
PubChem 3998
ChEMBL CHEMBL419
ChEBI CHEBI:6633
CCDC/CSD HSLSTZ