Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder.[L12885] It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).[L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively. Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.[L12885] Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors, and carries lesser activity at several off-targets which may responsible for some of its undesirable effects.[L12885]
Synonyms
Risperidone
Risperidone tartrate
Risperidona
Rispéridone
Risperidonum
Brand Names
Apo-risperidone
Dom-risperidone
Longavo
Ag-risperidone
PMS-risperidone ODT
Act Risperidone
Nu-risperidone
Sandoz Risperidone
Q-risperidone
Risperidone - 1
Risperdal M-tab
Risperdal Oral Solution
Dom-risperidone ODT
Risperidone
Jamp-risperidone
Uzedy
Okedi
Ipg-risperidone
Risperidone - 0.25
Riva-risperidone
Mylan-risperidone ODT
PMS-risperidone
Truemed Group LLC
Rykindo extended-release microspheres
Risperidone - 2
Mar-risperidone
Risperidone - 4
Ratio-risperidone
Mylan-risperidone
Ava-risperidone
Nb-risperidone
Mint-risperidon
Risperidone - 3
Ran-risperidone
PHL-risperidone
Pro-risperidone
Risperdal Consta
Risperidone - 0.5
Taro-risperidone
Perseris
PHL-risperidone ODT
Risperdal
Risperidone M-TAB
Risperidone Tablets
Risvan
Teva-risperidone
Indication
Risperidone is indicated for the treatment of schizophrenia [L12885,L44692,L46297] and irritability associated with autistic disorder.[L12885] It is also indicated as monotherapy, or adjunctly with lithium or valproic acid, for the treatment of acute mania or mixed episodes associated with bipolar I disorder.[L12885,L44692] Risperidone is additionally indicated in Canada for the short-term symptomatic management of aggression or psychotic symptoms in patients with severe dementia of the Alzheimer type unresponsive to nonpharmacological approaches.[L12906] Risperidone is also used off-label for a number of conditions including as an adjunct to antidepressants in treatment-resistant depression.[A177226]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
