Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder.[L12885] It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).[L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively. Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.[L12885] Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors, and carries lesser activity at several off-targets which may responsible for some of its undesirable effects.[L12885]
Synonyms
Risperidona
Rispéridone
Risperidone tartrate
Risperidone
Risperidonum
Brand Names
Riva-risperidone
Nu-risperidone
Risperdal
Dom-risperidone
Truemed Group LLC
Risperidone M-TAB
Jamp-risperidone
Dom-risperidone ODT
Ag-risperidone
Mylan-risperidone
Teva-risperidone
Risperidone Tablets
Risperidone
Ran-risperidone
Risperidone - 4
Perseris
Risperidone - 0.5
Risvan
Ipg-risperidone
Sandoz Risperidone
Apo-risperidone
Risperdal Consta
Act Risperidone
PMS-risperidone
Risperdal M-tab
PMS-risperidone ODT
Risperidone - 2
Ratio-risperidone
Risperidone - 1
Risperidone - 3
Taro-risperidone
Ava-risperidone
Mylan-risperidone ODT
PHL-risperidone
Risperidone - 0.25
Risperdal Oral Solution
Okedi
Mint-risperidon
Rykindo extended-release microspheres
Pro-risperidone
PHL-risperidone ODT
Q-risperidone
Uzedy
Mar-risperidone
Indication
Risperidone is indicated for the treatment of schizophrenia [L12885,L44692,L46297] and irritability associated with autistic disorder.[L12885] It is also indicated as monotherapy, or adjunctly with lithium or valproic acid, for the treatment of acute mania or mixed episodes associated with bipolar I disorder.[L12885,L44692] Risperidone is additionally indicated in Canada for the short-term symptomatic management of aggression or psychotic symptoms in patients with severe dementia of the Alzheimer type unresponsive to nonpharmacological approaches.[L12906] Risperidone is also used off-label for a number of conditions including as an adjunct to antidepressants in treatment-resistant depression.[A177226]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
