A1JT6

Glumetinib

Created:	2025-11-07
Last modified:	2026-02-18

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1 entries where A1JT6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	50
Chiral Atom Count	0
Bond Count	55
Aromatic Bond Count	30

2D diagram of A1JT6

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Chemical Component Summary
Name	Glumetinib
Synonyms	6-(1-methylpyrazol-4-yl)-1-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonyl-pyrazolo[4,3-b]pyridine
Systematic Name (OpenEye OEToolkits)	6-(1-methylpyrazol-4-yl)-1-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonyl-pyrazolo[4,3-b]pyridine
Formula	C₂₁ H₁₇ N₉ O₂ S
Molecular Weight	459.484
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	CACTVS	3.385	Cn1cc(cn1)c2ccc3ncc(n3c2)[S](=O)(=O)n4ncc5ncc(cc45)c6cnn(C)c6
SMILES	OpenEye OEToolkits	2.0.7	Cn1cc(cn1)c2ccc3ncc(n3c2)S(=O)(=O)n4c5cc(cnc5cn4)c6cnn(c6)C
Canonical SMILES	CACTVS	3.385	Cn1cc(cn1)c2ccc3ncc(n3c2)[S](=O)(=O)n4ncc5ncc(cc45)c6cnn(C)c6
Canonical SMILES	OpenEye OEToolkits	2.0.7	Cn1cc(cn1)c2ccc3ncc(n3c2)S(=O)(=O)n4c5cc(cnc5cn4)c6cnn(c6)C
InChI	InChI	1.06	InChI=1S/C21H17N9O2S/c1-27-11-16(7-24-27)14-3-4-20-23-10-21(29(20)13-14)33(31,32)30-19-5-15(6-22-18(19)9-26-30)17-8-25-28(2)12-17/h3-13H,1-2H3
InChIKey	InChI	1.06	RYBLECYFLJXEJX-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB15630
Name	Glumetinib
Groups	investigational
Description	Glumetinib is under investigation in clinical trial NCT04270591 (Assess the Anti-tumor Activity and Safety of Glumetinib in Patient With Advanced C-met-positive Non-small Cell Lung Cancer).
Synonyms	6-(1-methyl-1h-pyrazol-4-yl)-1-((6-(1-methyl-1h-pyrazol-4-yl)imidazo(1,2-a)pyridin-3-yl)sulfonyl)-1h-pyrazolo(4,3-b)pyridine Glumetinib
CAS number	1642581-63-2

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.