CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00257
Name	Clotrimazole
Groups	approved vet_approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	1-(o-Chloro-α,α-diphenylbenzyl)imidazole Clotrimazolum 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole Clotrimazol 1-(o-Chlorotrityl)imidazole 1-(α-(2-Chlorophenyl)benzhydryl)imidazole Clotrimazole
Brand Names	Live Better Antifungal PerfectHeal Antifungal CVS Clotrimazole Maximum Strength CVSHealth Antifungal Family Care Clotrimazole Anti-Fungal Cream 1% Canesten Vaginal Inserts 100mg Canesten 1% Topical Cream Canesten 1 Day Internal Cream Fastrin Anti - Fungal Skin Care Neo-zol Vaginal Cream 2% Quality Choice Clotrimazole PMS-clotrimazole-betamethasone Kroger ATHLETES FOOT Clotrimazole Antifungal Signature Care Antifungal Clotrimaderm Vaginal 3 CVS Pharmacy ITCH RELIEF ANTIFUNGAL Terrasil Anti-fungal Treatment Terrasil Antifungal Cream Maximum Strength Clotrimazole Extra Strength External Antifungal Cream Lucky SuperSoft Athletes Foot Botanimedix TineaRX Antifungal Drying Emulsion Alevazol Skin Repair meijer Clotrimazole 3 Clotrimazole-fluconazole Combi Shield and Protect Anti-Fungal Jock Itch Cream with Clotrimazole Signature Care Jock Itch ShopRite antifungal Footlogix Canesten 3 Day Internal Cream Major Clotrimazole Canesten 2% Vaginal Cream Best Choice Clotrimazole Canesten Extra Strength External Antifungal Cream Gyne-Lotrimin 7 Canesten Combi 3 Day Family Wellness Antifungal Myclo-gyne Cream 1% Kleer-Plex Fungistat Fungus Cure Clotrimazole Vaginal 3 Walgreens Jock Itch Zapotol Clotrimazole Footlogix Intensive Care Diabetic Formula Kleer-Plex Fungistat Athlete Foot Cure Terrasil Rapid-Clear Anti-Fungal Pedesil TheraPlus Plus Rugby Clotrimazole Antifungal Cream Atopalm Clotrimazole Antifungal Clotrimazole External Antifungal Cream Clotrimaderm Topical Solution 1% USP Gehwol med Foot Anti-Fungal Cream Canesten Crm 1% Vag Thera plus Antifungal Clotrimazole Protective Nail and skin CAREALL Clotrimazole Canesten Liq 1% Desenex Canesoral Combi 1 Day Canesten 6 Day Internal Cream Leader Clotrimazole Anti-Fungal Lotrisone Clotrimazol Dual First Aid Research Antifungal .5oz Sunmark Clotrimazole Hua Tuo Xian Gao Antifungal Anti Fungal Clotrimaderm-fluconazole Combi-pack Forticept Antifungal Cooling TerrasilMed ANTIFUNGAL Clotrimazole Vaginal 6 Terrasil Tinea Treatment MAX TopCare Clotrimazole 3 First Aid Research Antifungal Cream 1oz Fungicure Intensive Gehwol Nail Protection Pen Ciclomazole CVS Antifungal Ringworm Terbinafine HCl Chlortimazole and Tolnaftate UpandUp Clotrimazole Fortinia TopCare Antifungal Canesten Combi 1 Day Pedesil Maximum Strength Lotrimin Antifungal Family Care Clotrimazole Antifungal Myclo Solution Up and Up Athletes Foot Smooth Gator Fungus Eliminator Clotrimazole External Cream Good Neighbor Pharmacy Clotrimazole Myclo Crm 50mg Protective and Moisturizing Skin Fungicure Manicure Pedicure Smart Sense Athletes Foot Antifungal Olp Clotrimazole Foot Care Clotrimazole Gehwol Fusskraft Nail and Skin Protection Canesten Combi 1 Day Internal + External Creams FungaZoil Advanced Rugby Antifungal Clotrimazole Our Family Athletes Foot Occulus Skin Hydrating Topical Foam CLO-1 Canesten External Cream Equaline Antifungal Cream Shopko Athletes Foot Clotrimazole Topical Solution USP, 1% Publix athletic foot Walgreens Clotrimazole 3 Jock-eze Micotrin AC Antifungal Foot MakeSense Myclo-gyne Inserts Canesten Comfortab 3 Fungicure Manicure Pedicure Anti Fungal Jock Itch Clotrimazole Antifungal Neo-zol Cream 1% Silka Ringworm Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream Terrasil Anti-Fungal Treatment Athlete Foot Cream with Clotrimazole Anti-Fungal Family Care Antifungal Canesten Combi-pak 1 Day Therapy meijer Athletes Foot Clotrimazole Topical Solution 1% Clotrimazol Canesten 1% Topical Solution Gyne-Lotrimin 3 Aspiera Anti-Fungal Budpak Antifungal Clotrimazole Antifungal Cream Clotrimazole 1% Myclo Tab 100mg Good Sense Athletes Foot antifungal PRO-EX Anti Fungal Quality Choice Athletes Foot Clotrimaderm External Cream Oheal Ringworm Cream Family Wellness Clotrimazole 1 Anti Fungal Cream sunmark Clotrimazole 3 Terrasil Foot and Nail Anti-Fungal Canesten Comfortab 1 Terrasil Tinea Treatment Maximum Strength Fungicure Manicure Pedicure Liquid Gel Clotrimazole Jock Itch Soothing Antifungal Cream Clotrimazole/Betameth WinCo Foods Antifungal Jock Itch Antifungal Athletes Foot Clotrimazole and Betamethasone Dipropionate Myclo Crm 10mg Canesoral Combi HEB Antifungal Walgreens Clotrimazole Antifungal Up and Up Jock Itch Relief Fungicure Pumpspray Hua Tuo Xian Gao Blossom Pharmaceuticals Antifungal Meijer Clotrimazole Antifungal Ringworm Healthy Accents Antifungal Clotrimazole Akin Anti-fungal CAREONE Clotrimazole Terrasil JockItch Treatment Maximum Strength DermacinRx Therazole Pak Antifungal Neo-zol Vaginal Cream 1% Topcare Athletes Foot Scheinpharm Clotrimazole 1% JiDeSheng CVS Pharmacy Clotrimazole 3 Dr Sheffield Athletes Foot Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM 1MED Clotrimazole 1% Antifungal Cream Clotrimazole Cream 1% Canesten 3 Vaginal Tablet Combi-pak Clotrimazole Athletes Foot Meijer Athletes Foot Cream AF ClotrimazOil Antifungal Canesten External Antifungal Cream Extra Strength Clotrimazole Extra Fort -fluconazole Combi Fortinia OF Terrasil Jock-Itch Treatment MAX Astonea Clotrimazole 1% Athletes Foot Exchange Select Atheletes foot Forticept Antifungal Foot Gel S-Cream CLOTRIMAZOLE Cream 1% Clotrimaderm Topical Canesten 100mg Vaginal Inserts Femmesil Lakesia Equaline Clotrimazole Antifungal Clotrimazole 1% Athletes Foot Equate Jock Itch Clotrimazole 1% Topical Antifungal Cream Signature Care Athletes Foot SoundBody Clotrimazole Antifungal WinCo Antifungal Gerlasan Hand Canesten 200 Mg Vaginal Inserts Betamethasone Clotrimazole Kroger Jock Itch Mycozyl AC TM-Clotrimazole Cura Hongo Antifungal Clotrimazole Topical Terrasil Foot and Nail Anti-Fungal Maximum Strength Votriza-AL Clotrimaderm Vaginal 6 Athletes Foot Antifungal Antifungal Good Neighbor Pharmacy Clotrimazole 3 Athlete s Foot Afac Terrasil Jock Itch Treatment Maximum Strength Canesten 1 Vaginal Tablet Combi-pak Taro-clotrimazole/betamethasone Dipropionate Canesten Soft Capsule 1 Western Family Athletes Foot Canesten Crm 1% Top Goodsense Athletes Foot SIMPLY VITAL Antifungal Cream Canesten Combi 1 Day Comfortab + Extra Strength External Cream Terrasil Athletes Foot AntiFungal Treatment Max Lotriderm Au Kah Chuen Antifungal Rexall Jock Itch Terrasil Ringworm Treatment MAX Rexall Athletes Foot Walgreens Clotrimazole Mycelex Jock Itch Kerasal foot and toe Fungistat Max Oheal Manuka Honey Eczema Cream Terrasil Anti-Fungal Treatment MAX Forticept Antifungal Foot Cream Fungicure Liquid Gel Rite Aid antifungal ringworm Dermatin Antifungal Canesten V Myclo-derm Solution 1% Lotrimin Leader Athletes Foot Clotrimazole Aptrimazole 1.0% Antifungal Cream Dynarex Antifungal Myclo-derm Cream 1%
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
C-X-C chemokine receptor type 2	MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF...	unknown	modulator
Lanosterol 14-alpha demethylase	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682