CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00257
Name	Clotrimazole
Groups	vet_approved approved investigational
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole 1-(o-Chlorotrityl)imidazole Clotrimazole Clotrimazolum 1-(o-Chloro-α,α-diphenylbenzyl)imidazole 1-(α-(2-Chlorophenyl)benzhydryl)imidazole Clotrimazol
Brand Names	Equaline Clotrimazole Antifungal Clotrimazole Topical Goodsense Athletes Foot Canesten Combi 1 Day Leader Athletes Foot Clotrimazole Alevazol Myclo Crm 10mg Canesten 2% Vaginal Cream Clotrimazole Vaginal 3 TerrasilMed ANTIFUNGAL Myclo-gyne Inserts Ringworm Good Neighbor Pharmacy Clotrimazole 3 Pedesil Maximum Strength Walgreens Clotrimazole Oheal Ringworm Cream Antifungal Foot Shield and Protect Anti-Fungal Lotrisone CVS Clotrimazole Maximum Strength Zapotol Clotrimazole Dynarex Antifungal Clobezin Hua Tuo Xian Gao Antifungal Forticept Antifungal Cooling Canesten Comfortab 3 Thera plus Antifungal Clotrimazole TheraPlus Plus Botanimedix TineaRX Antifungal Drying Emulsion TopCare Clotrimazole 3 1MED Clotrimazole 1% Antifungal Cream Rugby Clotrimazole Antifungal Cream S-Cream CLOTRIMAZOLE Cream 1% Oheal Manuka Honey Eczema Cream WinCo Foods Antifungal Kroger Jock Itch Forticept Antifungal Foot Gel Betamethasone Clotrimazole Canesten 1 Vaginal Tablet Combi-pak Femmesil Myclo-derm Cream 1% Publix athletic foot Canesten 100mg Vaginal Inserts CVS Pharmacy Clotrimazole 3 Occulus Skin Hydrating Topical Foam CLO-1 Quality Choice Clotrimazole Myclo Tab 100mg SIMPLY VITAL Antifungal Cream Family Wellness Clotrimazole 1 Anti Fungal Cream Canesten 1% Topical Cream Clotrimazole Extra Strength External Antifungal Cream Clotrimaderm Topical Solution 1% USP Extra Strength Clotrimazole Extra Fort -fluconazole Combi Fungistat Max Canesten 1 Day Internal Cream Signature Care Antifungal Canesten 3 Vaginal Tablet Combi-pak Budpak Antifungal Clotrimazole First Aid Research Antifungal .5oz Terrasil Anti-fungal Treatment Anti-Fungal Major Clotrimazole TM-Clotrimazole Canesoral Combi 1 Day PMS-clotrimazole-betamethasone meijer Athletes Foot Fortinia OF Good Sense Athletes Foot antifungal Neo-zol Vaginal Cream 1% Canesten Combi-pak 1 Day Therapy Clotrimazole Topical Solution 1% Terrasil Foot and Nail Anti-Fungal Maximum Strength Equate Jock Itch Terrasil Tinea Treatment MAX Walgreens Clotrimazole 3 Lotrimin Antifungal Family Care Clotrimazole Antifungal Jock Itch Antifungal Walgreens Jock Itch Canesten Soft Capsule 1 Myclo-gyne Cream 1% Gyne-Lotrimin 3 Clotrimazole Topical Solution USP, 1% Athletes Foot Antifungal Antifungal TopCare Antifungal Clotrimazole 1% Athletes Foot Best Choice Clotrimazole Foot Care Clotrimazole Jock Itch Cream with Clotrimazole Equaline Antifungal Cream Clotrimaderm Topical Gerlasan Hand Fastrin Anti - Fungal Skin Care HEB Antifungal Myclo-derm Solution 1% Lucky SuperSoft Athletes Foot Canesten Combi 3 Day Soothing Antifungal Cream Rexall Athletes Foot Terrasil Anti-Fungal Treatment MAX Canesten External Cream Kerasal foot and toe Myclo Solution Protective Nail and skin ClotrimazOil Antifungal Clotrimaderm Vaginal 3 Canesten Extra Strength External Antifungal Cream PRO-EX Anti Fungal Family Care Antifungal Meijer Clotrimazole Antifungal Canesten Crm 1% Vag Clotrimazole Micotrin AC Kroger ATHLETES FOOT Canesten 200 Mg Vaginal Inserts Akin Anti-fungal Aptrimazole 1.0% Antifungal Cream Gehwol Nail Protection Pen Shopko Athletes Foot Clotrimazole Cream 1% Fungicure Liquid Gel Gyne-Lotrimin 7 Terrasil Jock-Itch Treatment MAX Our Family Athletes Foot Smooth Gator Fungus Eliminator Clotrimazole/Betameth Scheinpharm Clotrimazole 1% Antifungal Cream Canesten Crm 1% Top Gehwol Fusskraft Nail and Skin Protection Good Neighbor Pharmacy Clotrimazole Desenex Leader Clotrimazole Anti-Fungal Athlete s Foot Afac Footlogix Intensive Care Diabetic Formula JiDeSheng Astonea Clotrimazole 1% Athletes Foot meijer Clotrimazole 3 Neo-zol Cream 1% CAREONE Clotrimazole Quality Choice Athletes Foot Rexall Jock Itch Fortinia UpandUp Clotrimazole Blossom Pharmaceuticals Antifungal Walgreens Clotrimazole Antifungal Clotrimazole Antifungal Kleer-Plex Fungistat Fungus Cure Fungicure Intensive Terrasil Antifungal Cream Maximum Strength CVS Antifungal Ringworm Gehwol med Foot Au Kah Chuen Antifungal PerfectHeal Antifungal Clotrimazole External Antifungal Cream Atopalm Clotrimazole Antifungal CVS Pharmacy ITCH RELIEF ANTIFUNGAL MakeSense Up and Up Athletes Foot Canesoral Combi Terrasil Jock Itch Treatment Maximum Strength Antifungal Lotriderm Fungicure Manicure Pedicure Liquid Gel Terrasil Athletes Foot AntiFungal Treatment Max Terrasil Anti-Fungal Treatment Clotrimazole 1% Topical Antifungal Cream DermacinRx Therazole Pak Protective and Moisturizing Skin Athletes Foot Canesten 6 Day Internal Cream Silka Ringworm Fungicure Manicure Pedicure Canesten V Myclo Crm 50mg Canesten Comfortab 1 Clotrimazole Jock Itch Mycozyl AC Clotrimazole Athletes Foot Anti-Fungal Cream Clotrimaderm-fluconazole Combi-pack Terrasil Rapid-Clear Anti-Fungal Terrasil Tinea Treatment Maximum Strength Canesten 1% Topical Solution Canesten Combi 1 Day Internal + External Creams Clotrimazole and Betamethasone Dipropionate Signature Care Athletes Foot Clotrimazol Dual Terbinafine HCl Chlortimazole and Tolnaftate Topcare Athletes Foot Canesten Liq 1% Clotrimazole External Cream FungaZoil Advanced Meijer Athletes Foot Cream AF Healthy Accents Antifungal Dermatin Antifungal Dr Sheffield Athletes Foot Ciclomazole Canesten Vaginal Inserts 100mg Clotrimazole-fluconazole Combi Athlete Foot Cream with Clotrimazole Canesten Combi 1 Day Comfortab + Extra Strength External Cream Fungicure Manicure Pedicure Anti Fungal Hua Tuo Xian Gao Live Better Antifungal Jock-eze Family Wellness Antifungal Footlogix Terrasil Ringworm Treatment MAX ShopRite antifungal Rite Aid antifungal ringworm Up and Up Jock Itch Relief Votriza-AL Terrasil Foot and Nail Anti-Fungal Smart Sense Athletes Foot Antifungal Anti Fungal Clotrimaderm Vaginal 6 Forticept Antifungal Foot Cream Clotrimazole Vaginal 6 CAREALL Clotrimazole Cura Hongo Antifungal Signature Care Jock Itch Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream Aspiera Anti-Fungal Skin Repair Jock Itch Clotrimazole Antifungal Kleer-Plex Fungistat Athlete Foot Cure Western Family Athletes Foot First Aid Research Antifungal Cream 1oz Taro-clotrimazole/betamethasone Dipropionate Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM Family Care Clotrimazole Anti-Fungal Cream 1% sunmark Clotrimazole 3 CVSHealth Antifungal Pedesil Clotrimazol Neo-zol Vaginal Cream 2% Fungicure Pumpspray WinCo Antifungal Mycelex Canesten 3 Day Internal Cream Jock Itch Clotrimazole 1% Exchange Select Atheletes foot Lotrimin Clotrimaderm External Cream Lakesia SoundBody Clotrimazole Antifungal Terrasil JockItch Treatment Maximum Strength Olp Clotrimazole Sunmark Clotrimazole Rugby Antifungal Clotrimazole Canesten External Antifungal Cream
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Lanosterol 14-alpha demethylase	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
C-X-C chemokine receptor type 2	MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF...	unknown	modulator
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682