Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.[A32038,L12855] Due to its high hydrophilicity and poor absorption profile,[A32038] prodrug ,[fenofibrate], and other conjugated compounds of fenofibric acid, such as choline fenofibrate, have been developed for improved solubility, gastrointestinal absorption, and bioavailability, and more convenient administration.[A32038,A193362]
Synonyms
Choline fenofibrate
Fenofibric acid
Brand Names
Fenofibric Acid
Trilipix
Fenofibric Acid Delayed-release
Fibricor
Fenofibric Acid Delayed-Release
Fenofibric acid
Indication
For use as an adjunctive therapy to diet to: (a) reduce triglyceride levels in adult patients with severe hypertriglyceridemia, and (b) reduce elevated total cholesterol, low-density-lipoprotein (LDL-C), triglycerides, and apolipoprotein B, and to increase high-density-lipoprotein (HDL-C) in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). [FDA Label]
Categories
Acids, Acyclic
Agents Causing Muscle Toxicity
Anticholesteremic Agents
Benzene Derivatives
Benzophenones
Butyrates
Drugs that are Mainly Renally Excreted
Ethers
Fibric Acids
Hypolipidemic Agents
Hypolipidemic Agents Indicated for Hyperlipidemia
Isobutyrates
Ketones
Lipid Modifying Agents
Lipid Modifying Agents, Plain
Lipid Regulating Agents
Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
