HCY

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

Created:	2007-10-13
Last modified:	2021-03-01

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13 entries where HCY is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	7
Bond Count	59
Aromatic Bond Count	0

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Chemical Component Summary
Name	(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Synonyms	CORTISOL
Systematic Name (OpenEye OEToolkits)	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Formula	C₂₁ H₃₀ O₅
Molecular Weight	362.46
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(CO)C3(O)C2(CC(O)C4C1(C(=CC(=O)CC1)CCC4C2CC3)C)C
SMILES	CACTVS	3.341	C[C]12CCC(=O)C=C1CC[CH]3[CH]4CC[C](O)(C(=O)CO)[C]4(C)C[CH](O)[CH]23
SMILES	OpenEye OEToolkits	1.5.0	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Canonical SMILES	CACTVS	3.341	C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI	InChI	1.03	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	InChI	1.03	JYGXADMDTFJGBT-VWUMJDOOSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00741
Name	Hydrocortisone
Groups	vet_approved approved
Description	Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Synonyms	Hidrocortisona 4-pregnen-11β,17α,21-triol-3,20-dione Kendall's compound F Cortisol Hydrocortisonum 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione 11beta-hydrocortisone Hydrocortisone Reichstein's substance M 11β-hydrocortisone 17-Hydroxycorticosterone (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Brand Names	Blue-Emu Anti-Itch Cream Rephresh Cooling Meijer Anti Itch Cream Plus NeilMed Anti-Itch Family Wellness Maximum Strength Hydrocortisone Pramoxine-HC S-Oint HYDROCORTISONE 1% Corticol-Aloe Hydrocortisone Plus 12 Moisturizers Maximum Strength Itch and Rash Cream Glytone soothe calming Family Care Hydrocortisone Neomycin and Polymyxin B Sulfates and Hydrocortisone Odan Proctomyxin HC Suppositories Hydrocortisone Cream 0.5% USP HEM-EASY RELIEF Herbal Anti-Itch MAXIMUM ITCH RELIEF S-Cream HYDROCORTISONE 1% Hydrocortisone 2.5% / Ketoconazole 2% Cortisone 10 Intensive Moisture Creme BudPak Anti-Itch Refuge HC Anti Itch Aveeno Hydrocortisone Anti-itch Cream Family Wellness Max Strength 1 Hydrocortisone Cream Rugby Hydrocortisone With Aloe Itch and Bite Relief First Aid Kit FixMySkin Healing Balm Fragrance-Free Pharmaskincare Acnecare Cream HydroCortisone Intensive Healing Formula Hydrocortisone HC Itch Fixer Freds Hydrocortisone with Aloe Maximum-H Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula Sunmark Hydrocortisone with Aloe Maximum Strength Rexall Hydrocortisone Plus Moisturizers 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Weeks and Leo Anti-itch WinCo Maximum Strength Hydrocortisone Alacort Hydrocortisone Maximum Strength with aloe Cortizone 10 for Psoriasis Anti-Itch Regular Strength Alumier MD Intensive Recovery Hydrocortisone 0.5% / Hydroquinone 6% Medi-First Plus Hydrocortisone Publix hydro plus Hydrocortisone Ointment 1% OLIVIA QUIDO FIRM and FADE I Instant Cooling Itch Relief OREAD GOLD Anti-Itch Foam Anti Itch Maximum Strength Plus Vioform Hydrocortisone Mild Welly Superhero Supplies Kit UEC Medical Anti-Itch Audiologist Anti-itch Cortenema Sus 100mg/60ml Hydroxym Cream Assured Maximum Strength Anti-Itch Anusol HC Anti-Itch with Aloe Western Family HydroCortisone Plus 12 Moisturizers Insect Bite Relief Alumier MD Post Procedure Kit with Hydrocortisone Proctozone HC CeraVe Anti-Itch Emo Cort Cream 2.5% Cortizone 10 Poison Ivy Relief Pads Equate Hydrocortisone Topical Cortaid Maximum Strength Premier Value Hydrocortisone Plus 12 Moisturizers Harris Teeter Anti-Itch with Aloe Publix Hydro Cortisone Ana Cool Rapid Soothing Cooling Formula Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% CVS Pharmacy Anti-itch Neo-poly-bac Hydro Hydrocortisone 1% with healing aloe Cortizone 10 Harris Teeter Maximum Strength Anti-Itch Western Family HydroCortisone CVS Anti-Itch Hydrocortisone DG Health Hydrocortisone HydroSKIN FIRST Marys Mouthwash Compounding Hydrocortisone Cream USP 0.5% Proctosedyl Equaline Anti Itch Careone Hydrocortisone 1 Maximum Strength Family Wellness Hydrocortisone Caring Mills Hydrocortisone Triple Antibiotic HC Duane Reade hydrocortisone plus 12 moisturizers Hydroxym Pediadermics Eczema 2 Aquanil HC Colocort Quatriderm Anti-itch Beard Medicated Cremo CVS Cortisone Hydrocortisone Micro Hydrocortisone With Aloe Natureplex Hydrocortisone Hydro Nizoral Scalp Itch Relief Maximum Strength Hydrocortisone Cream with Aloe 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Cortizone 10 Water Resistant CVS Maximum Strength Feminine Anti-Itch Cream Ti-U-lac HC Lotion Monistat Complete Care Instant Itch Relief PS-2896 Hydrocortisone Cream 1%, 0.9g Meijer Max. Strength Anti-Itch Cream Intensive Healing Formula Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Avedana Hydrocortisone Cream with Aloe CVS Health Maxium Strentgh Cortisone Alkindi Sprinkle Meijer Intense Healing Freds Hydrocortisone Plus 12 Moisturizers Rite Aid anti-itch Walgreens Hydrocortisone Plus 12 Moisturizers Maximum Strength Cortizone 10 Quick Shot 360 Continuous Welly Excursion First Aid Kit Hydrocortisone Plus 12 Moisturizers Proactiv Solution Anti-Itch Scalp Auro-hydrocortisone Harris Teeter Anti-Itch Intensive Healing Cortizone 10 Intensive Healing Feminine Itch Relief Hydrocort Cortizone 10 Easy Relief Hytone Vioform + Hydrocortisone NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE Cortaid 12-Hour Advanced Anti-Itch Intensive Healing Eczema Preparation H Soothing Relief Anti-itch Maximum Strength Cortisone Dermoscribe Ichybum Face Values Hydrocortisone With Aloe Anti-Itch Scherer Labs Loesch Anti-Itch Therapy Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers Rexall Hydrocortisone 1 Proctocort Aquacort Lotion 2.5% Neomycin, Polymyxin B Sulfates and Hydrocortisone DG Health Hydrocortisone Maximum Strength AVON HeXashield Anti Itch Cream with Healing Aloe Emo Cort Sol 2.5% USP Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Oticin HC Ear Drops Vioform Hydrocortisone CVS Cools Itch Fast Selsun Blue Scalp Itch Treatment Thera plus Anti-itch with aloe Hydrocortisone Avedana Hydrocortisone Maximum Strength Makesense Maximum Strength Caldecort Quality Choice Anti Itch with Aloe meijer Itch and Rash Relief FixMySkin Healing Balm Vanilla Flavor Discount Drug Mart Anti-itch FixMySkin HEALING BODY BALM Fragrance-Free Loesch HC-10 ANTI-ITCH THERAPY Post peel Protectant Vitality Institute Quality Choice Anti Itch Hydrocortisone 1 Plus 10 NU-DERM Tolereen Anti-pruritic Equate Hydrocortisone CareOne Anti Itch Our Family Hydrocortisone with Aloe Cipro HC Otic Suspension Dermazene Hydrocortisone 1% Hydrocortisone 1% in Absorbase Cortizone 10 Sensitive Skin Anti-itch Creme Cortisporin Pediaderm HC Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone Hydrocortisone Maximum Strength with Aloe Texacort hydrocortisone Iodoquinol Yes To Coconut Eczema Relief Bioelements Immediate Comfort Hydrocortisone Cortisporin Ophthalmic Petrocort Antipruritic Lip 21 Healthy Accents Cortisone Maximum Strength Aloe Cort Cortizone 10 Itch Relief Massaging Rollerball Sterex Lot Plus 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Hemorrodil Unguento Plus Market Basket Anti-Itch Cream Plus Tecnu Corticool Quatriderm Creme Nf Healing Tree Calming Anti-itch Proctosol-HC Cortisone 10 Overnight Creme Hydrocortisone Cream Intensive Healing Pediotic Psoriasin Itch Control Topcare Hydrocortisone meijer Hydrocortisone glo SKIN BEAUTY Remedy Gel FIRST Dukes Mouthwash Compounding Antibiotic Ear (Neo/Polym/HC) Proctosedyl Ointment Hydrocortisone and Acetic Acid Bencort Shopko Maximum Strength TrueLipids Anti-Itch Barrier Eczema Skin Mushatts N9 Itch Stuff Dg Health Hydrocortisone Hydroxate Gel Piyanping antiitch Cooling Itch Relief Well at Walgreens Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin Vosol HC DermaCort Anti-itch OLIVIA QUIDO FIRM and FADE II Oto End 10 Mycozyl HC Cream Gel Pharmaskincare Multi-Gly Skin Relief Cream Dermarest Eczema Medicated ECOLAB Hydrocortisone Cream Meijer Anti Itch ATOPALM Moisturizing Hydrocortisone Scalpicin Anti-Itch Maximum Strength Fulton Street Market Anti itch Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Cortisone Plus Aloe Maximum Strength Scarguard MD Cortibalm Itch Relief TheraCare Maximum Strength 1% Hydrocortisone Cortizone 10 Hydratensive Healing Anti Itch 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Schein Hydrocortisone Zims Advanced Crack Creme With Hydrocortisone Cipro HC Harris Teeter Anti-Itch Cooling Relief Dr. Sheffield Hydrocortisone Anti itch FixMySkin Healing Balm Unflavored Aloe Cort Calming Cream Proctosedyl Suppositories Hydrocortisone Regular Strength SAFEWAY Hydrocortisone Plus 12 Moisturizers Hydrocortisone Intensive Healing Formula Smart Sense Anti Itch Cortizone 10 Hydratensive Soothing Anti Itch Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% signature care Hydrocortisone Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe sunmark Hydrocortisone Barmicil Anti-itch Efmody Herb Street Anti-Itch Stick Hydrocaine Hydrocortisone Ultra Strength Welly Adventure First Aid Kit Quality Choice Anti-Itch Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers Cortizone 10 Feminine Itch Relief Cortizone 10 Anti-itch for Diabetics Skin Gelmicin Hydrocortisone with Aloe Thera Plus Healerz for Itches Meijer Maximum Strength Anti-itch Cream with Aloe Shopko Hydrocortisone Intensive Healing Formula Meijer Anti-itch with Aloe Theraplex AIM Anti-Itch Moisturizing Cream Cortaine -B Aqueous Shoprite Hydrocortisone Hycort Retention Enema 100mg/60ml Up and Up Hydrocortisone Anti Itch Poison Oak and Ivy Cicatricure Ultra Moisturizing Meijer Maximum Strength Anti-itch Cream Ultra Moisturizing Formula 1oz Aquaphor Itch Relief Cortisone Cream Intensive Healing FixMySkin HEALING LIP BALM unflavoured Quality Choice Hydrocortisone Maximum Strength Hydrocortisone Hydrocortisone Anti Itch Cortate Crm 1% Berkley and Jensen Hydrocortisone Ala Quin Advanced Hydrocortisone Hydrocortisone Cream Instant Cooling Itch Relief CVS Green Guard Maximum Strength Hydrocortisone Medi-Cortisone with Aloe Hydrocortisone Iodoquinol 999 Itch Relieving Hydrocortisone maximum strength SKIN A COOL Hydrocortisone Anti-Itch Up and Up Hydrocortisone Basic Case Hydrocortisone Anti-Itch Equaline Anti Itch Maximum Strength Berkley and Jensen Anti Itch TopCare Hydrocortisone Hydrocortisone Crm 0.5% Casporyn HC Cho-A Care Lot 1% Exchange Select Hydrocortisone TopCare Hydrocortisone Plus 12 Moisturizers Scarguard MD Physicians Formula Cortate Ont 1% Shopko Hydrocortisone Maximum Strength Winco Maximum Strength Hydrocortisone Sunmark Hydrocortisone Plus Aveeno Hydrocortisone ANTI-ITCH Cortizone 10 Plus First Aid Only Hydrocortisone 1% Anti-Itch Signature Care Hydrocortisone Anti-itch Feminine Care Hydrocortisone with Aloe Odan Proctomyxin HC Cortizone 10 Intensive Healing Hydrocortisone Butyrate Cortisone 10 Sensitive Skin Creme Live Better Hydrocortisone with Aloe Hydrocortisone Cream 1% with Aloe Vera Alcortin Welly Human Repair Kit Cortef Anti itch HydroSkin Hydrocortisone With Aloe Maximum Strength Good Sense Anti Itch Family Care Anti-Itch Hydro Skin CliniCalm Xerese Hydrocortisone Plus 10 Moisturizers Sandoz Cortimyxin Welly Itch Fix Cortizone 10 Cooling Cream Anti-Itch Hydrocortisone Plus Dr Lift Soothing Cream Hydrocortisone 1 Leader Hydrocortisone Up and Up Anti Itch Good Neighbor Pharmacy Hydrocortisone CeraVe Developed with Dermatologists Anti Itch HydrocortisoneLotion Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Meijer Maximum Strength Anti-itch Cream wiith Aloe DG health hydrocortisone Cooling Itch Relief Cortane-B Vanoxide HC Maximum Strength Cortisone Cream with Aloe Kirkland Signature Hydrocortisone Plus Maximum Strength Cortizone 10 Intensive Healing for Eczema Rodan and Fields Soothe WinCo Foods Hydrocortisone Cream Intensive Healing Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension Odan-spor-HC Poison Oak Up and Up Intensive Healing Anti-itch Kera HC Home PapKit Up and Up anti itch maximum strength Post Treatment Balm Anti Itch Maximum Strength ProCure Hydrocortisone Plus Calendula Soothe Rodan Fields Xpect Hydrocortisone Sandoz Hydrocortisone Rite Aid Cortisone Lucky SuperSoft MAXIMUM STRENGTH Cortizone 10 Cooling KAISER PERMANENTE Hydrocortisone Post-Treatment Repair Cream H Plus Holdings Nourishing Hydrocortisone, Iodoquinol Neosporin Eczema Essentials Anti Itch TopCare Hydrocortisone Intensive Healing Formula Barmicil Plus Smart Sense Anti Itch Maximum Strength Care One hydrocortisone maximum strength Care One Hydrocortisone Maximum Strength Premier Value Hydrocortisone Cortisone Maximum Strength Dermarest Dricort 0.5% Hydrocortisone Anti-itch Aveeno Hydrocortisone Anti Itch Hydrocortisone Maximum Strength Proctol Ointment Texacort Solution 1% Rexall Anti Itch Maximum Strength Relief Hydrocortisone Cream 0.5% Procto-Pak Sterex Crm Plus Plenadren Hydrocortisone with Aloe Maximum Strength Quality Choice Hydrocortisone Maximum Strength Proctocream HC Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, TopCare Hydrocortisone 1% with Aloe Proctozone-HC Dermoscribe Seborrheic Dermatitis Barriere HC 1% Regular Strength Hydrocortisone Cream Family Wellness Good Neighbor Pharmacy Anti Itch WINCO Hydrocortisone Corti-Sav Medi-First Hydrocortisone Equate Hydrocortisone Intensive Healing Formula Leader Hydrocortisone With Aloe Hydrocortisone Quality Choice Itch Relief Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Smart sense Hydrocortisone Anti-Itch Scalp Relief Maximum Strength Emo Cort Lotion 2.5% Crane Safety Hydrocortisone 1% Hydrocortisone Cortaid Intensive Therapy Cooling Shopko Hydrocortisone FixMySkin Healing Balm Vanilla Fragrance Formu Care Anti Itch maximum strength CVS Health Hydrocortisone Anti Itch Duane Reade hydrocortisone Hydrocortisone D H-Releve Anti-Itch Duane Reade Cortizone-10 Soothing Aloe Creme Maximum Strength Hydrocortisone Cream Monistat Soothing Care Itch Relief Basic Care Hydrocortisone Proctosedyl Sup Rugby Hydroskin Theracort Dermasorb AF Complete Kit Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2% Cipro Cortenema Dr. Throwers Hydrotet HeXashield Anti Itch Cream with Healing Aloe Neosporin Essentials Trial Pack Welly First Aid Kit Cortizone 10 Overnight Itch Relief Total Relief Cortizone 10 Ultra Soothing Creme Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% Up and Up Hydrocortisone One Per Cent Cooling Itch Relief Rite Aid Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% OLP Hydrocortisone 1% Shopko Hydrocortisone With Aloe TheraCare Hydrocortisone Cream Cvs Hydrocortisone With Aloe Cortizone 10 Cooling Relief Ketocon Maximum Strength Hydrocortisone Plus Moisturizing Aloe Viniferamine Hydrocortisone Cream Members Mark Hydrocortisone Preparation H Hydrocortisone Hydro Ear Hydrocortisone Rectal Suspension (Retention) Anti-Itch SeaCalm Skin Itch Relief Instant Cooling Hydrocortisone Cream 1% Alkindi Careone Anti Itch Meijer Maximum Strength Anti-itch Calmurid HC Crm AFASSCO 1% Hydrocortisone Dermaquest Skin Therapy Post-Skin Resurfacing Balm Quality Choice Maximum Strength Anti Itch Medi-First Hydrocortisone anti-itch plus Proctol Suppositories Hydrocortisone Crm 1% Harris Teeter Anti-Itch Itch relief Cream Up and Up anti itch Hydrocortisone Anti-Itch TrueLipids 1% Hydrocortisone Barrier Cream Apres Peel Soothing Balm Dr H Stabilizer Hydrocortisone with aloe Intensive Healing Anti Itch Health Mart Pharmacy Hydrocortisone Maximum Strength with Aloe Mycozyl HC meijer Hydrocortisone Plus 12 Moisturizers Procto-Med HC ProCure Hydrocortisone Cream Plus Acetasol HC CVS Anti itch Cortisone maximum strength Good Neighbor Pharmacy Hydrocortisone with Aloe Hydrocortisone Continuous Pharmaskincare Brightening Dermarelief Cream Hydrocortisone Ointment 0.5% Quadrydern ShopRite Hydrocortisone CVS Maximum Strength Anti-Itch Cream Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength Oti Rx Signature Care Anti Itch Smart Sense Hydrocortisone Scalpicin Scalp Itch Medication Maximum Strength Sarna HC Atopalm Maximum Strength Anti-Itch Sarna Whipped Foam Scalpicin Maximum Strength Ala-Scalp Cortomycin
Indication	Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Categories	11-Hydroxycorticosteroids 17-Hydroxycorticosteroids Adrenal Cortex Hormones Adrenals Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Alimentary Tract and Metabolism Anti-Inflammatory Agents Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Corticosteroid Hormone Receptor Agonists Corticosteroids Corticosteroids Acting Locally Corticosteroids for Local Oral Treatment Corticosteroids for Systemic Use Corticosteroids for Systemic Use, Plain Corticosteroids, Dermatological Preparations Corticosteroids, Weak (Group I) Cytochrome P-450 CYP2A6 Inducers Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Dermatologicals Fused-Ring Compounds Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hydrocortisone and derivatives Hydroxycorticosteroids Hyperglycemia-Associated Agents Immunosuppressive Agents Intestinal Antiinflammatory Agents Nasal Preparations OAT3/SLC22A8 Substrates Ophthalmological and Otological Preparations Ophthalmologicals Otologicals P-glycoprotein inducers P-glycoprotein substrates Pregnanes Pregnenediones Pregnenes Sensory Organs Steroids Stomatological Preparations Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Vasoprotectives
ATC-Code	S01CB03 A01AC03 S01BA02 S01CA03 D07AA02 S01BB01 D07XA01 D07BA04 S02CA03 A07EA02 S02BA01 R01AD60 H02AB09 D07CA01 S03CA04 C05AA01
CAS number	50-23-7

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Glucocorticoid receptor	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAV...	unknown	agonist
Annexin A1	MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAA...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	substrate
Cytochrome P450 11B1, mitochondrial	MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWL...	unknown	substrate
Cytochrome P450 11B2, mitochondrial	MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWL...	unknown	substrate
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inducer
Aldo-keto reductase family 1 member D1	MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYR...	unknown	substrate
3-oxo-5-alpha-steroid 4-dehydrogenase 2	MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPAR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase type 2	MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase 1	MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREM...	unknown	substrate
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inducer
Cytochrome P450 1B1	MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSA...	unknown	inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inducer
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inducer
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inducer
Sex hormone-binding globulin	MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNG...	unknown	binder
Corticosteroid-binding globulin	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSL...	unknown	binder
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate,inducer
Solute carrier organic anion transporter family member 1A2	MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQ...	unknown	inhibitor
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL389621
PubChem	5754
ChEMBL	CHEMBL389621
ChEBI	CHEBI:17650
CCDC/CSD	ZZZPNG01, ZZZPNG03, GOGQEZ, CORTMS01, COWNEI, CORTMS, ZZZPNG02, CORTPY, SACWAY01, SACWAY, ZZZPNG04
COD	1559402