HCY

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

Created:	2007-10-13
Last modified:	2021-03-01

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13 entries where HCY is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	7
Bond Count	59
Aromatic Bond Count	0

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Chemical Component Summary
Name	(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Synonyms	CORTISOL
Systematic Name (OpenEye OEToolkits)	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Formula	C₂₁ H₃₀ O₅
Molecular Weight	362.46
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(CO)C3(O)C2(CC(O)C4C1(C(=CC(=O)CC1)CCC4C2CC3)C)C
SMILES	CACTVS	3.341	C[C]12CCC(=O)C=C1CC[CH]3[CH]4CC[C](O)(C(=O)CO)[C]4(C)C[CH](O)[CH]23
SMILES	OpenEye OEToolkits	1.5.0	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Canonical SMILES	CACTVS	3.341	C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI	InChI	1.03	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	InChI	1.03	JYGXADMDTFJGBT-VWUMJDOOSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00741
Name	Hydrocortisone
Groups	approved vet_approved
Description	Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Synonyms	17-Hydroxycorticosterone Hidrocortisona (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione 11β-hydrocortisone Hydrocortisone 4-pregnen-11β,17α,21-triol-3,20-dione 11beta-hydrocortisone Hydrocortisonum 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione Cortisol Kendall's compound F Reichstein's substance M
Brand Names	FixMySkin Healing Balm Unflavored Aloe Cort Duane Reade hydrocortisone plus 12 moisturizers Leader Hydrocortisone With Aloe Sandoz Cortimyxin Meijer Anti Itch Cream Plus Thera Plus Sterex Lot Plus Quality Choice Hydrocortisone Advanced Hydrocortisone Equaline Anti Itch Dermaquest Skin Therapy Post-Skin Resurfacing Balm Up and Up Hydrocortisone Dermarest Eczema Medicated Piyanping antiitch Family Care Anti-Itch Hydrocortisone Maximum Strength Dr. Sheffield Hydrocortisone Anti itch 1% Hydrocortisone Dermarest Dricort 0.5% Hydrocortisone Anti-itch Emo Cort Sol 2.5% USP Harris Teeter Anti-Itch with Aloe Meijer Intense Healing Winco Maximum Strength Hydrocortisone Hydrocortisone With Aloe Auro-hydrocortisone Family Care Hydrocortisone Proctosol-HC Cortisone Dermoscribe Ichybum FixMySkin Healing Balm Fragrance-Free Discount Drug Mart Anti-itch Healerz for Itches Poison Oak Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension S-Oint HYDROCORTISONE 1% Psoriasin Itch Control Hytone Maximum Strength Cortisone Cream with Aloe Meijer Maximum Strength Anti-itch Cream wiith Aloe Aquaphor Itch Relief Alcortin Family Wellness Max Strength 1 Hydrocortisone Cream Hydrocortisone Plus 12 Moisturizers Maximum Strength NeilMed Anti-Itch WinCo Maximum Strength Hydrocortisone Basic Case Hydrocortisone Anti-Itch FIRST Marys Mouthwash Compounding FixMySkin HEALING LIP BALM unflavoured ProCure Hydrocortisone Cream Plus Harris Teeter Anti-Itch Cooling Relief OLIVIA QUIDO FIRM and FADE II Proctosedyl Cortaid Maximum Strength Cortizone 10 Feminine Itch Relief 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Hydrocaine Hydrocortisone 2.5% / Ketoconazole 2% Aveeno Hydrocortisone Anti Itch Cortizone 10 Plus Hydrocortisone Intensive Healing Formula Sunmark Hydrocortisone with Aloe Maximum Strength Hydrocortisone Ointment 0.5% Cortizone 10 Cooling Relief Proactiv Solution Anti-Itch Scalp Medi-First Smart Sense Anti Itch AFASSCO 1% Hydrocortisone Acetasol HC Maximum Strength Hydrocortisone Plus Moisturizing Aloe Vioform + Hydrocortisone Shoprite Hydrocortisone Rexall Hydrocortisone 1 Welly Superhero Supplies Kit Rugby Hydrocortisone With Aloe Anti itch Anti Itch Maximum Strength Health Mart Pharmacy Hydrocortisone Maximum Strength with Aloe Live Better Hydrocortisone with Aloe Texacort ECOLAB Hydrocortisone Cream Up and Up anti itch Maximum Strength Cortizone 10 Quick Shot 360 Continuous Hydrocortisone and Acetic Acid Odan Proctomyxin HC Triple Antibiotic HC Premier Value Hydrocortisone Sandoz Hydrocortisone Alkindi Sprinkle Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone Pediaderm HC Ala Quin CVS Cools Itch Fast Hydrocortisone 0.5% / Hydroquinone 6% Anti-itch ShopRite Hydrocortisone Alkindi Proctol Ointment Exchange Select Hydrocortisone Scalpicin Maximum Strength Natureplex Hydrocortisone Hydro Proctol Suppositories Anusol HC Quality Choice Anti Itch Scarguard MD Physicians Formula Gelmicin Hydrocortisone with Aloe Fulton Street Market Anti itch Hydroxym Cooling Itch Relief Cortisone Plus Aloe Maximum Strength Proctocort Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% HydroSkin Cortomycin Pramoxine-HC Cipro HC Preparation H Hydrocortisone CVS Maximum Strength Feminine Anti-Itch Cream Cortizone 10 Intensive Healing Feminine Itch Relief Hydrocortisone Cream 1% Maximum Strength Hydrocortisone Cream with Aloe Signature Care Anti Itch Cortizone 10 Easy Relief HEM-EASY RELIEF Herbal Anti-Itch MAXIMUM ITCH RELIEF Hydrocortisone Cream USP 0.5% Rexall Hydrocortisone Plus Moisturizers Market Basket Anti-Itch Cream Plus Up and Up anti itch maximum strength Aquacort Lotion 2.5% H-Releve Anti-Itch Mycozyl HC Cream Gel SAFEWAY Hydrocortisone Plus 12 Moisturizers Anti-Itch Regular Strength Cvs Hydrocortisone With Aloe WINCO Hydrocortisone Quality Choice Hydrocortisone Maximum Strength Texacort Solution 1% Cortate Crm 1% Neo-poly-bac Hydro meijer Itch and Rash Relief Alumier MD Intensive Recovery Cipro HC Otic Suspension Duane Reade hydrocortisone Theraplex AIM Anti-Itch Moisturizing Cream Cortisporin Ophthalmic H Plus Holdings Nourishing Vanoxide HC First Aid Only Hydrocortisone 1% Anti-Itch Dermasorb AF Complete Kit Itch Stuff Quatriderm Creme Nf Sarna HC Barmicil Anti-itch Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Quality Choice Anti Itch with Aloe Equate Hydrocortisone Topical Total Relief Medi-Cortisone with Aloe Proctozone HC Itch Fixer Maximum Strength Anti-Itch Cortisone Maximum Strength Cortizone 10 Anti-itch for Diabetics Skin Odan Proctomyxin HC Suppositories Aveeno Hydrocortisone Anti-itch Cream CVS Health Hydrocortisone Anti Itch Vosol HC Corticol-Aloe CVS Anti itch Antibiotic Ear (Neo/Polym/HC) Cortef Hydrocortisone Butyrate Medi-First Hydrocortisone Scalpicin Scalp Itch Medication Maximum Strength Cortisone maximum strength Dr H Stabilizer Intensive Healing Anti Itch FIRST Dukes Mouthwash Compounding OREAD GOLD Anti-Itch Foam Duane Reade Harris Teeter Maximum Strength Anti-Itch Zims Advanced Crack Creme With Hydrocortisone Meijer Max. Strength Anti-Itch Cream Intensive Healing Formula 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Neomycin, Polymyxin B Sulfates and Hydrocortisone Casporyn HC Members Mark Hydrocortisone Scalpicin Anti-Itch Maximum Strength Berkley and Jensen Hydrocortisone Anti-Itch Scalp Relief Maximum Strength Home PapKit Nizoral Scalp Itch Relief Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Maximum Strength Hydrocortisone FixMySkin Healing Balm Vanilla Flavor Dermazene Mycozyl HC Welly Itch Fix Bioelements Immediate Comfort Hydrocortisone Quality Choice Itch Relief Anti-Itch with Aloe HydroSKIN TheraCare Maximum Strength 1% Hydrocortisone SeaCalm Skin Itch Relief Instant Cooling Kirkland Signature Hydrocortisone Plus Maximum Strength Selsun Blue Scalp Itch Treatment Western Family HydroCortisone Plus 12 Moisturizers Sterex Crm Plus Atopalm Maximum Strength Anti-Itch Proctosedyl Sup Proctozone-HC Vioform Hydrocortisone Mild Aloe Cort Calming Cream Meijer Maximum Strength Anti-itch FixMySkin Healing Balm Vanilla Fragrance Preparation H Soothing Relief Anti-itch Hydro Skin Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Cortizone-10 Soothing Aloe Creme PS-2896 Hydrocortisone Cream 1%, 0.9g Premier Value Hydrocortisone Plus 12 Moisturizers Smart Sense Anti Itch Maximum Strength Cooling Itch Relief Well at Walgreens Proctosedyl Ointment Meijer Maximum Strength Anti-itch Cream with Aloe OLIVIA QUIDO FIRM and FADE I Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% TopCare Hydrocortisone 1% with Aloe Post-Treatment Repair Cream Cortisone 10 Sensitive Skin Creme TheraCare Hydrocortisone Cream Avedana Hydrocortisone Maximum Strength Caldecort Insect Bite Relief Crane Safety Hydrocortisone NU-DERM Tolereen Anti-pruritic Welly Human Repair Kit Caring Mills Hydrocortisone Hydrocortisone D Oticin HC Ear Drops Post peel Protectant Vitality Institute Hydrocortisone Ointment 1% Shopko Hydrocortisone With Aloe Maximum-H Harris Teeter Anti-Itch Intensive Healing Dermoscribe Seborrheic Dermatitis Hydrocortisone Rodan and Fields Soothe Cortisporin Cicatricure Ultra Moisturizing Blue-Emu Anti-Itch Cream Hydrocortisone Anti Itch Publix Hydro Up and Up Hydrocortisone One Per Cent Publix hydro plus 999 Itch Relieving Emo Cort Cream 2.5% Schein Hydrocortisone meijer Hydrocortisone Plus 12 Moisturizers Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe Hydrocortisone anti-itch plus Pharmaskincare Multi-Gly Skin Relief Cream Harris Teeter Anti-Itch DG Health Hydrocortisone Maximum Strength signature care Hydrocortisone Aveeno Hydrocortisone ANTI-ITCH Quadrydern Yes To Coconut Eczema Relief CVS Maximum Strength Anti-Itch Cream Herb Street Anti-Itch Stick Neomycin and Polymyxin B Sulfates and Hydrocortisone Intensive Healing Eczema Care One hydrocortisone maximum strength FixMySkin HEALING BODY BALM Fragrance-Free Equate Hydrocortisone Hydrocortisone Plus Good Sense Anti Itch Hydrocortisone with Aloe Maximum Strength Healing Tree Calming Anti-itch Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Hydrocortisone 1% in Absorbase 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Colocort DG health hydrocortisone Eczema Skin Mushatts N9 Cooling Itch Relief Rite Aid Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin Hydrocortisone Cream 0.5% USP Hydroxym Cream Hydrocortisone Rectal Suspension (Retention) Cortizone 10 Intensive Healing for Eczema Dr. Throwers Hydrotet Cortisone Cream Intensive Healing Cortizone 10 Hydratensive Soothing Anti Itch Itch relief Cream S-Cream HYDROCORTISONE 1% Thera plus Anti-itch with aloe Hydrocortisone Monistat Complete Care Instant Itch Relief Cortizone 10 Intensive Healing Cortizone 10 Overnight Itch Relief Hydrocortisone Plus 12 Moisturizers Assured Ala-Scalp Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers AVON HeXashield Anti Itch Cream with Healing Aloe Cortizone 10 for Psoriasis Smart Sense Hydrocortisone ATOPALM Moisturizing Hydrocortisone Careone Anti Itch Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula Instant Cooling Itch Relief CVS Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% Calmurid HC Crm Family Wellness Maximum Strength Hydrocortisone Cortate Ont 1% Hydrocortisone Plus 10 Moisturizers Hydrocortisone Micro Ana Cool Rapid Soothing Cooling Formula KAISER PERMANENTE Hydrocortisone Basic Care Hydrocortisone CeraVe Developed with Dermatologists Anti Itch Viniferamine Hydrocortisone Cream Hydrocortisone with Aloe CVS Anti-Itch Hydrocortisone Freds Hydrocortisone Plus 12 Moisturizers DG Health Hydrocortisone Cortisone 10 Overnight Creme Xerese Hydrocortisone Crm 0.5% CliniCalm Family Wellness Hydrocortisone Equate Hydrocortisone Intensive Healing Formula Cortane-B Maximum Strength Hydrocortisone Cream TrueLipids Anti-Itch Barrier HeXashield Anti Itch Cream with Healing Aloe Cortizone 10 Water Resistant Refuge HC Instant Cooling Itch Relief Shopko Hydrocortisone Maximum Strength 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Cortizone 10 Itch Relief Massaging Rollerball Berkley and Jensen Anti Itch Careone Hydrocortisone 1 Maximum Strength Quality Choice Anti-Itch Scarguard MD Formu Care Anti Itch maximum strength Tecnu Corticool Cortibalm Hydrocortisone Anti-Itch Emo Cort Lotion 2.5% Post Treatment Balm Soothe Rodan Fields Aquanil HC Up and Up Hydrocortisone Anti Itch hydrocortisone Iodoquinol Good Neighbor Pharmacy Anti Itch Hycort Retention Enema 100mg/60ml Rite Aid Cortisone Makesense Maximum Strength Cortaine -B Aqueous Xpect Hydrocortisone BudPak Anti-Itch Lucky SuperSoft MAXIMUM STRENGTH Glytone soothe calming Hydrocortisone Crm 1% Welly Excursion First Aid Kit Anti Itch Healthy Accents Cortisone Maximum Strength Hydrocortisone Regular Strength Shopko Hydrocortisone Hydrocortisone Cream Intensive Healing Cortizone 10 Poison Ivy Relief Pads Proctocream HC Care One Hydrocortisone Maximum Strength Face Values Hydrocortisone With Aloe Good Neighbor Pharmacy Hydrocortisone with Aloe Alumier MD Post Procedure Kit with Hydrocortisone CareOne Anti Itch Hydrocort Meijer Anti-itch with Aloe Proctosedyl Suppositories Cortizone 10 Cooling Loesch HC-10 ANTI-ITCH THERAPY Kera HC Shopko Maximum Strength Smart sense Hydrocortisone Hydrocortisone 1% ProCure Hydrocortisone Plus Calendula CVS Health Maxium Strentgh Cortisone Family Wellness Beard Medicated Cremo Neosporin Eczema Essentials Anti Itch Cipro Audiologist Anti-itch Cortizone 10 Sensitive Skin Anti-itch Creme Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Rugby Hydroskin TopCare Hydrocortisone Plus 12 Moisturizers WinCo Foods Hydrocortisone Cream Intensive Healing Welly First Aid Kit Poison Oak and Ivy DermaCort Anti-itch Equaline Anti Itch Maximum Strength Up and Up Anti Itch Neosporin Essentials Trial Pack Rite Aid anti-itch Itch Relief Regular Strength Hydrocortisone Cream Cortizone 10 Ultra Soothing Creme Hydrocortisone Iodoquinol Meijer Maximum Strength Anti-itch Cream Ultra Moisturizing Formula 1oz NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE Western Family HydroCortisone Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone HydroCortisone Intensive Healing Formula Bencort Hydrocortisone 1 HydrocortisoneLotion Anti Itch Maximum Strength Plus Petrocort Antipruritic Lip 21 Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength Cortizone 10 Hydratensive Healing Anti Itch Hemorrodil Unguento Plus Monistat Soothing Care Itch Relief Sunmark Hydrocortisone Plus Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2% meijer Hydrocortisone Alacort OLP Hydrocortisone 1% Procto-Med HC Hydrocortisone Cream 1% with Aloe Vera Hydrocortisone HC Hydrocortisone with aloe Pediotic Hydrocortisone Continuous Rephresh Cooling Pediadermics Eczema 2 Hydrocortisone Ultra Strength Barriere HC 1% Pharmaskincare Acnecare Cream Hydrocortisone Maximum Strength with Aloe Cortizone 10 Cooling Cream Anti-Itch Itch and Bite Relief First Aid Kit Leader Hydrocortisone Hydrocortisone With Aloe Maximum Strength Pharmaskincare Brightening Dermarelief Cream Cortaid Intensive Therapy Cooling Hydrocortisone, Iodoquinol Sarna Whipped Foam Hydrocortisone 1 Plus 10 Walgreens Hydrocortisone Plus 12 Moisturizers Theracort Ketocon Anti-itch Feminine Care Medi-First Plus Hydrocortisone Shopko Hydrocortisone Intensive Healing Formula Green Guard Maximum Strength Hydrocortisone CVS Cortisone Cortisone 10 Intensive Moisture Creme Anti-Itch Up and Up Intensive Healing TopCare Hydrocortisone Intensive Healing Formula UEC Medical Anti-Itch Quality Choice Maximum Strength Anti Itch Cortenema Sus 100mg/60ml Hydrocortisone Cream 0.5% SKIN A COOL Hydrocortisone Anti-Itch CeraVe Anti-Itch Hydrocortisone maximum strength Anti-Itch Scherer Labs Avedana Hydrocortisone Cream with Aloe Plenadren Our Family Hydrocortisone with Aloe Loesch Anti-Itch Therapy Welly Adventure First Aid Kit sunmark Hydrocortisone Hydro Ear Cortizone 10 Vioform Hydrocortisone Hydrocortisone 1% with healing aloe Barmicil Plus Rexall Anti Itch Maximum Strength Relief Corti-Sav Dr Lift Soothing Cream Meijer Anti Itch Hydroxate Gel Cho-A Care Lot 1% Quatriderm Anti-itch Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers Oto End 10 CVS Pharmacy Anti-itch Apres Peel Soothing Balm TopCare Hydrocortisone Weeks and Leo Anti-itch Topcare Hydrocortisone Odan-spor-HC Maximum Strength Cortisone TrueLipids 1% Hydrocortisone Barrier Cream Efmody Procto-Pak Ti-U-lac HC Lotion Good Neighbor Pharmacy Hydrocortisone Freds Hydrocortisone with Aloe Cortaid 12-Hour Advanced Anti-Itch Dg Health Hydrocortisone Hydrocortisone Cream Cortenema Itch and Rash Cream glo SKIN BEAUTY Remedy Gel Hydrocortisone Maximum Strength with aloe Oti Rx Signature Care Hydrocortisone
Indication	Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Categories	11-Hydroxycorticosteroids 17-Hydroxycorticosteroids Adrenal Cortex Hormones Adrenals Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Alimentary Tract and Metabolism Anti-Inflammatory Agents Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Corticosteroid Hormone Receptor Agonists Corticosteroids Corticosteroids Acting Locally Corticosteroids for Local Oral Treatment Corticosteroids for Systemic Use Corticosteroids for Systemic Use, Plain Corticosteroids, Dermatological Preparations Corticosteroids, Weak (Group I) Cytochrome P-450 CYP2A6 Inducers Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Dermatologicals Fused-Ring Compounds Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hydrocortisone and derivatives Hydroxycorticosteroids Hyperglycemia-Associated Agents Immunosuppressive Agents Intestinal Antiinflammatory Agents Nasal Preparations OAT3/SLC22A8 Substrates Ophthalmological and Otological Preparations Ophthalmologicals Otologicals P-glycoprotein inducers P-glycoprotein substrates Pregnanes Pregnenediones Pregnenes Sensory Organs Steroids Stomatological Preparations Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Vasoprotectives
ATC-Code	S01CB03 A01AC03 S01BA02 S01CA03 D07AA02 S01BB01 D07XA01 D07BA04 S02CA03 A07EA02 S02BA01 R01AD60 H02AB09 D07CA01 S03CA04 C05AA01
CAS number	50-23-7

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Glucocorticoid receptor	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAV...	unknown	agonist
Annexin A1	MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAA...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	substrate
Cytochrome P450 11B1, mitochondrial	MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWL...	unknown	substrate
Cytochrome P450 11B2, mitochondrial	MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWL...	unknown	substrate
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inducer
Aldo-keto reductase family 1 member D1	MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYR...	unknown	substrate
3-oxo-5-alpha-steroid 4-dehydrogenase 2	MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPAR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase type 2	MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase 1	MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREM...	unknown	substrate
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inducer
Cytochrome P450 1B1	MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSA...	unknown	inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inducer
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inducer
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inducer
Sex hormone-binding globulin	MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNG...	unknown	binder
Corticosteroid-binding globulin	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSL...	unknown	binder
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate,inducer
Solute carrier organic anion transporter family member 1A2	MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQ...	unknown	inhibitor
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL389621
PubChem	5754
ChEMBL	CHEMBL389621
ChEBI	CHEBI:17650
CCDC/CSD	ZZZPNG01, ZZZPNG03, GOGQEZ, CORTMS01, COWNEI, CORTMS, ZZZPNG02, CORTPY, SACWAY01, SACWAY, ZZZPNG04
COD	1559402