HCY

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

Created:	2007-10-13
Last modified:	2021-03-01

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13 entries where HCY is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	7
Bond Count	59
Aromatic Bond Count	0

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Chemical Component Summary
Name	(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Synonyms	CORTISOL
Systematic Name (OpenEye OEToolkits)	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Formula	C₂₁ H₃₀ O₅
Molecular Weight	362.46
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(CO)C3(O)C2(CC(O)C4C1(C(=CC(=O)CC1)CCC4C2CC3)C)C
SMILES	CACTVS	3.341	C[C]12CCC(=O)C=C1CC[CH]3[CH]4CC[C](O)(C(=O)CO)[C]4(C)C[CH](O)[CH]23
SMILES	OpenEye OEToolkits	1.5.0	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Canonical SMILES	CACTVS	3.341	C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI	InChI	1.03	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	InChI	1.03	JYGXADMDTFJGBT-VWUMJDOOSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00741
Name	Hydrocortisone
Groups	approved investigational vet_approved
Description	Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Synonyms	Hidrocortisona (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione 17-Hydroxycorticosterone Hydrocortisonum 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione Hydrocortisone Kendall's compound F 4-pregnen-11β,17α,21-triol-3,20-dione Reichstein's substance M 11β-hydrocortisone Cortisol 11beta-hydrocortisone
Brand Names	Anti Itch Maximum Strength Family Care Anti-Itch Emo Cort Sol 2.5% USP Freds Hydrocortisone Plus 12 Moisturizers Duane Reade Efmody Cortisone CVS Cools Itch Fast Avedana Hydrocortisone Cream with Aloe Pharmaskincare Acnecare Cream Cipro Crane Safety Hydrocortisone Pediotic Hydrocortisone Ultra Strength KAISER PERMANENTE Hydrocortisone Gelmicin Hydrocortisone with Aloe Cortizone 10 Cooling Procto-Med HC Calmurid HC Crm Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Western Family HydroCortisone Plus 12 Moisturizers Hydrocortisone With Aloe Maximum Strength Hydrocortisone Ointment 0.5% Corti-Sav Exchange Select Hydrocortisone Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% DG Health Hydrocortisone Maximum Strength Itch Fixer TrueLipids 1% Hydrocortisone Barrier Cream Hydrocortisone Crm 0.5% DG Health Hydrocortisone Maximum Strength Cortisone Cream with Aloe Cortizone 10 TrueLipids Anti-Itch Barrier Neomycin, Polymyxin B Sulfates and Hydrocortisone Shoprite Hydrocortisone Aveeno Hydrocortisone ANTI-ITCH Nizoral Scalp Itch Relief CVS Cortisone FixMySkin HEALING BODY BALM Fragrance-Free Proctosedyl Ointment Itch Relief CliniCalm Hydroxym Cream Cortisone maximum strength Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Welly Itch Fix AVON HeXashield Anti Itch Cream with Healing Aloe 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Proactiv Solution Anti-Itch Scalp Smart Sense Hydrocortisone NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE Hydrocortisone Micro Cortizone 10 Itch Relief Massaging Rollerball Hydrocortisone with Aloe Maximum Strength Texacort Up and Up anti itch Quadrydern Equate Hydrocortisone Intensive Healing Formula Face Values Hydrocortisone With Aloe Walgreens Hydrocortisone Plus 12 Moisturizers Welly Adventure First Aid Kit Hydrocortisone Intensive Healing Formula Berkley and Jensen Anti Itch Apres Peel Soothing Balm Cortisone 10 Intensive Moisture Creme Aquaphor Itch Relief CVS Maximum Strength Feminine Anti-Itch Cream Maximum-H Medi-First Hydrocortisone Cortaid Intensive Therapy Cooling Loesch Anti-Itch Therapy Theracort Up and Up Intensive Healing Hycort Retention Enema 100mg/60ml Scalpicin Anti-Itch Maximum Strength Petrocort Antipruritic Lip 21 Cortizone 10 Overnight Itch Relief Avedana Hydrocortisone Maximum Strength H-Releve Anti-Itch Oto End 10 Sunmark Hydrocortisone with Aloe Maximum Strength Insect Bite Relief Harris Teeter Maximum Strength Anti-Itch Anti Itch Pediadermics Eczema 2 Our Family Hydrocortisone with Aloe Scarguard MD Physicians Formula CVS Health Hydrocortisone Anti Itch Hydrocortisone Cream 1% with Aloe Vera Cortaid Maximum Strength Alumier MD Post Procedure Kit with Hydrocortisone Anti-Itch Regular Strength OLP Hydrocortisone 1% HEM-EASY RELIEF Herbal Anti-Itch MAXIMUM ITCH RELIEF Quality Choice Anti Itch NU-DERM Tolereen Anti-pruritic Soothe Rodan Fields Bioelements Immediate Comfort Hydrocortisone Cortizone 10 Sensitive Skin Anti-itch Creme Quatriderm Creme Nf Cortizone 10 Hydratensive Soothing Anti Itch Cortizone 10 Plus ProCure Hydrocortisone Plus Calendula DG health hydrocortisone Health Mart Pharmacy Hydrocortisone Maximum Strength with Aloe CeraVe Anti-Itch Proctosedyl Care One hydrocortisone maximum strength Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, Hydrocortisone Rectal Suspension (Retention) Duane Reade hydrocortisone Good Sense Anti Itch Quality Choice Anti-Itch Bencort Dermazene Hemorrodil Unguento Plus Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin Natureplex Hydrocortisone Hydro Sandoz Cortimyxin TopCare Hydrocortisone Intensive Healing Formula Maximum Strength Cortisone HydroSKIN TopCare Hydrocortisone Plus 12 Moisturizers Hydrocortisone Cream 0.5% USP meijer Itch and Rash Relief Hydrocortisone Crm 1% Texacort Solution 1% Pharmaskincare Multi-Gly Skin Relief Cream Family Wellness Hydrocortisone Dermaquest Skin Therapy Post-Skin Resurfacing Balm Shopko Hydrocortisone Maximum Strength glo SKIN BEAUTY Remedy Gel Aquanil HC Kera HC Hydroxym Harris Teeter Anti-Itch Intensive Healing Anusol HC Khindivi Equaline Anti Itch Odan Proctomyxin HC Cortisone Plus Aloe Maximum Strength Pediaderm HC Aloe Cort Aveeno Hydrocortisone Anti-itch Cream Up and Up anti itch maximum strength Good Neighbor Pharmacy Hydrocortisone Antibiotic Ear (Neo/Polym/HC) Meijer Anti Itch Cream Plus Quality Choice Hydrocortisone S-Oint HYDROCORTISONE 1% TopCare Hydrocortisone 1% with Aloe Mycozyl HC Cream Gel FIRST Dukes Mouthwash Compounding Good Neighbor Pharmacy Anti Itch Quality Choice Anti Itch with Aloe Cortizone 10 Water Resistant Premier Value Hydrocortisone Plus 12 Moisturizers Hydrocortisone Hydrocortisone Butyrate Smart Sense Anti Itch Maximum Strength 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Basic Case Hydrocortisone Anti-Itch Assured Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Hydrocortisone 2.5% / Ketoconazole 2% Shopko Hydrocortisone With Aloe Hydrocortisone Cream USP 0.5% Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2% Home PapKit Hydrocortisone Anti Itch Oticin HC Ear Drops HeXashield Anti Itch Cream with Healing Aloe Cortaine -B Aqueous Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers Alkindi WinCo Maximum Strength Hydrocortisone Duane Reade hydrocortisone plus 12 moisturizers PS-2896 Hydrocortisone Cream 1%, 0.9g Glytone soothe calming Proctozone-HC Hydrocortisone with aloe Anti-itch Feminine Care Ketocon Careone Anti Itch Maximum Strength Cortizone 10 Quick Shot 360 Continuous BudPak Anti-Itch signature care Hydrocortisone Aloe Cort Calming Cream Refuge HC Quality Choice Itch Relief Welly Excursion First Aid Kit Thera Plus Sterex Crm Plus Cortate Ont 1% Meijer Anti-itch with Aloe S-Cream HYDROCORTISONE 1% Alkindi Sprinkle Preparation H Hydrocortisone Hydrocortisone 1% Proctol Ointment Intensive Healing Anti Itch Dr Lift Soothing Cream WinCo Foods Hydrocortisone Cream Intensive Healing Neosporin Essentials Trial Pack Maximum Strength Hydrocortisone Cream with Aloe Meijer Maximum Strength Anti-itch Cream wiith Aloe Cicatricure Ultra Moisturizing Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength Loesch HC-10 ANTI-ITCH THERAPY ATOPALM Moisturizing Hydrocortisone Publix Hydro Itch Stuff Alumier MD Intensive Recovery CVS Anti-Itch Hydrocortisone Meijer Maximum Strength Anti-itch Cream Ultra Moisturizing Formula 1oz OLIVIA QUIDO FIRM and FADE I Publix hydro plus Cooling Itch Relief Well at Walgreens Family Wellness Leader Hydrocortisone Hydrocortisone Plus Basic Care Hydrocortisone Sandoz Hydrocortisone Hydrocortisone with Aloe Up and Up Anti Itch Proctosol-HC Members Mark Hydrocortisone Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Pharmaskincare Brightening Dermarelief Cream FixMySkin Healing Balm Vanilla Flavor Aveeno Hydrocortisone Anti Itch CVS Health Maxium Strentgh Cortisone Casporyn HC Cortizone 10 Intensive Healing Dr H Stabilizer Rodan and Fields Soothe Shopko Hydrocortisone Intensive Healing Formula Vioform Hydrocortisone Mild 1% Hydrocortisone NeilMed Anti-Itch Vosol HC Cortisporin 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Cipro HC FixMySkin Healing Balm Unflavored TopCare Hydrocortisone Rugby Hydrocortisone With Aloe Barriere HC 1% Cortef Dermoscribe Ichybum Hydrocortisone Regular Strength Aquacort Lotion 2.5% Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe Hydrocort Monistat Soothing Care Itch Relief Lucky SuperSoft MAXIMUM STRENGTH Hytone Hydrocortisone Maximum Strength Fulton Street Market Anti itch Cortizone 10 Poison Ivy Relief Pads Hydrocortisone Anti-Itch Hydrocortisone Maximum Strength with aloe Cortizone 10 Anti-itch for Diabetics Skin Post peel Protectant Vitality Institute Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% Neosporin Eczema Essentials Anti Itch Signature Care Hydrocortisone Theraplex AIM Anti-Itch Moisturizing Cream Cortenema Harris Teeter Anti-Itch with Aloe Hydrocortisone HC Dg Health Hydrocortisone Cortizone 10 Cooling Relief Hydrocortisone D Cortenema Sus 100mg/60ml FIRST Marys Mouthwash Compounding Proctol Suppositories Cortane-B Cortizone 10 Cooling Cream Anti-Itch Hydrocortisone With Aloe UEC Medical Anti-Itch Cortizone-10 Soothing Aloe Creme Hydrocortisone 0.5% / Hydroquinone 6% Total Relief ShopRite Hydrocortisone Vioform Hydrocortisone meijer Hydrocortisone Cortizone 10 Intensive Healing for Eczema Hydrocortisone anti-itch plus Anti itch Odan-spor-HC 999 Itch Relieving Hydrocortisone Maximum Strength with Aloe Pramoxine-HC Maximum Strength Hydrocortisone Cream Topcare Hydrocortisone Vioform + Hydrocortisone Meijer Maximum Strength Anti-itch Sarna HC Careone Hydrocortisone 1 Maximum Strength Itch and Rash Cream Oti Rx Acetasol HC Ala Quin Maximum Strength Anti-Itch Procto-Pak Healing Tree Calming Anti-itch Corticol-Aloe CVS Maximum Strength Anti-Itch Cream Rexall Hydrocortisone Plus Moisturizers Regular Strength Hydrocortisone Cream Triple Antibiotic HC Barmicil Anti-itch Anti-Itch Hydrocortisone Plus 10 Moisturizers Alacort Berkley and Jensen Hydrocortisone hydrocortisone Iodoquinol Healthy Accents Cortisone Maximum Strength Hydrocortisone maximum strength Rite Aid Cortisone Sunmark Hydrocortisone Plus Cortisone Cream Intensive Healing meijer Hydrocortisone Plus 12 Moisturizers Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers Cortisporin Ophthalmic Proctocort Shopko Hydrocortisone Atopalm Maximum Strength Anti-Itch Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Yes To Coconut Eczema Relief Formu Care Anti Itch maximum strength Hydrocortisone Ointment 1% Cvs Hydrocortisone With Aloe Market Basket Anti-Itch Cream Plus Healerz for Itches Hydrocortisone Cream 0.5% Sarna Whipped Foam Tecnu Corticool Cipro HC Otic Suspension First Aid Only Hydrocortisone 1% Anti-Itch Discount Drug Mart Anti-itch Anti-itch Barmicil Plus Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone Leader Hydrocortisone With Aloe Caring Mills Hydrocortisone Hydrocortisone 1% with healing aloe CeraVe Developed with Dermatologists Anti Itch Smart sense Hydrocortisone Colocort Advanced Hydrocortisone Hydrocortisone 1 Rexall Hydrocortisone 1 Emo Cort Cream 2.5% Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% Equaline Anti Itch Maximum Strength Xerese Post-Treatment Repair Cream Smart Sense Anti Itch Equate Hydrocortisone Topical Rexall Anti Itch Maximum Strength Relief Cortisone 10 Sensitive Skin Creme SAFEWAY Hydrocortisone Plus 12 Moisturizers Hydroxate Gel Rephresh Cooling WINCO Hydrocortisone Scarguard MD Cortisone Maximum Strength Hydrocortisone Plus 12 Moisturizers Thera plus Anti-itch with aloe Hydrocortisone Up and Up Hydrocortisone Anti Itch Hydrocortisone 1 Plus 10 Family Wellness Max Strength 1 Hydrocortisone Cream Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula Family Wellness Maximum Strength Hydrocortisone 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Anti-Itch with Aloe SeaCalm Skin Itch Relief Instant Cooling Dermoscribe Seborrheic Dermatitis Freds Hydrocortisone with Aloe Hydrocortisone 1% in Absorbase Ana Cool Rapid Soothing Cooling Formula FixMySkin Healing Balm Fragrance-Free Up and Up Hydrocortisone One Per Cent Cortisone 10 Overnight Creme TheraCare Hydrocortisone Cream Herb Street Anti-Itch Stick Itch relief Cream Up and Up Hydrocortisone HydroCortisone Intensive Healing Formula Family Care Hydrocortisone Eczema Skin Mushatts N9 ECOLAB Hydrocortisone Cream Green Guard Maximum Strength Hydrocortisone OREAD GOLD Anti-Itch Foam Itch and Bite Relief First Aid Kit Cortizone 10 for Psoriasis Meijer Max. Strength Anti-Itch Cream Intensive Healing Formula Schein Hydrocortisone Caldecort Proctosedyl Sup Winco Maximum Strength Hydrocortisone Weeks and Leo Anti-itch DermaCort Anti-itch Quatriderm Anti-itch Medi-First Plus Hydrocortisone Cortizone 10 Intensive Healing Feminine Itch Relief Harris Teeter Anti-Itch Cooling Relief OLIVIA QUIDO FIRM and FADE II Signature Care Anti Itch Plenadren Hydrocortisone Continuous Cortizone 10 Ultra Soothing Creme Ala-Scalp Cortate Crm 1% Anti-Itch Scalp Relief Maximum Strength Cooling Itch Relief Rite Aid Hydrocaine ProCure Hydrocortisone Cream Plus Neo-poly-bac Hydro CVS Pharmacy Anti-itch Dermarest Dricort 0.5% Hydrocortisone Anti-itch Cooling Itch Relief Hydrocortisone Cream Intensive Healing Dr. Sheffield Hydrocortisone Anti itch Quality Choice Maximum Strength Anti Itch Dermarest Eczema Medicated Instant Cooling Itch Relief CVS Mycozyl HC Alcortin Selsun Blue Scalp Itch Treatment Welly Human Repair Kit Scalpicin Scalp Itch Medication Maximum Strength Maximum Strength Hydrocortisone Plus Moisturizing Aloe Auro-hydrocortisone Xpect Hydrocortisone Proctozone HC Quality Choice Hydrocortisone Maximum Strength Maximum Strength Hydrocortisone Sterex Lot Plus Beard Medicated Cremo Odan Proctomyxin HC Suppositories Hydrocortisone Cream 1% HydrocortisoneLotion Anti-Itch Scherer Labs Meijer Anti Itch Vanoxide HC Zims Advanced Crack Creme With Hydrocortisone Meijer Maximum Strength Anti-itch Cream with Aloe Ti-U-lac HC Lotion Hydrocortisone Cream Rite Aid anti-itch Equate Hydrocortisone Welly Superhero Supplies Kit Audiologist Anti-itch Hydro Skin Live Better Hydrocortisone with Aloe Dermasorb AF Complete Kit HydroSkin FixMySkin HEALING LIP BALM unflavoured Hydrocortisone Iodoquinol Good Neighbor Pharmacy Hydrocortisone with Aloe Blue-Emu Anti-Itch Cream Hydrocortisone, Iodoquinol Proctocream HC Psoriasin Itch Control Meijer Intense Healing Medi-Cortisone with Aloe Neomycin and Polymyxin B Sulfates and Hydrocortisone Medi-First Premier Value Hydrocortisone Welly First Aid Kit Preparation H Soothing Relief Anti-itch Poison Oak Makesense Maximum Strength Piyanping antiitch Post Treatment Balm Care One Hydrocortisone Maximum Strength Cortizone 10 Hydratensive Healing Anti Itch CareOne Anti Itch Cortomycin Instant Cooling Itch Relief Shopko Maximum Strength Anti Itch Maximum Strength Plus Cortizone 10 Feminine Itch Relief Western Family HydroCortisone CVS Anti itch Cho-A Care Lot 1% Monistat Complete Care Instant Itch Relief FixMySkin Healing Balm Vanilla Fragrance Poison Oak and Ivy Cortibalm AFASSCO 1% Hydrocortisone Rugby Hydroskin Cortizone 10 Easy Relief Hydrocortisone Plus 12 Moisturizers Maximum Strength Intensive Healing Eczema Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension Hydro Ear SKIN A COOL Hydrocortisone Anti-Itch Kirkland Signature Hydrocortisone Plus Maximum Strength Harris Teeter Anti-Itch Scalpicin Maximum Strength H Plus Holdings Nourishing Cortaid 12-Hour Advanced Anti-Itch Viniferamine Hydrocortisone Cream sunmark Hydrocortisone Proctosedyl Suppositories Dr. Throwers Hydrotet Emo Cort Lotion 2.5% TheraCare Maximum Strength 1% Hydrocortisone Hydrocortisone and Acetic Acid
Indication	Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Categories	11-Hydroxycorticosteroids 17-Hydroxycorticosteroids Adrenal Cortex Hormones Adrenals Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Alimentary Tract and Metabolism Anti-Inflammatory Agents Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Corticosteroid Hormone Receptor Agonists Corticosteroids Corticosteroids Acting Locally Corticosteroids for Local Oral Treatment Corticosteroids for Systemic Use Corticosteroids for Systemic Use, Plain Corticosteroids, Dermatological Preparations Corticosteroids, Weak (Group I) Cytochrome P-450 CYP2A6 Inducers Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Dermatologicals Fused-Ring Compounds Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hydrocortisone and derivatives Hydroxycorticosteroids Hyperglycemia-Associated Agents Immunosuppressive Agents Intestinal Antiinflammatory Agents Nasal Preparations OAT3/SLC22A8 Substrates Ophthalmological and Otological Preparations Ophthalmologicals Otologicals P-glycoprotein inducers P-glycoprotein substrates Pregnanes Pregnenediones Pregnenes Sensory Organs Steroids Stomatological Preparations Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Vasoprotectives
ATC-Code	S01CB03 A01AC03 S01BA02 S01CA03 D07AA02 S01BB01 D07XA01 D07BA04 S02CA03 A07EA02 S02BA01 R01AD60 H02AB09 D07CA01 S03CA04 C05AA01
CAS number	50-23-7

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Glucocorticoid receptor	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAV...	unknown	agonist
Annexin A1	MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAA...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	substrate
Cytochrome P450 11B1, mitochondrial	MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWL...	unknown	substrate
Cytochrome P450 11B2, mitochondrial	MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWL...	unknown	substrate
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inducer
Aldo-keto reductase family 1 member D1	MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYR...	unknown	substrate
3-oxo-5-alpha-steroid 4-dehydrogenase 2	MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPAR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase type 2	MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase 1	MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREM...	unknown	substrate
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inducer
Cytochrome P450 1B1	MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSA...	unknown	inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inducer
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inducer
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inducer
Sex hormone-binding globulin	MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNG...	unknown	binder
Corticosteroid-binding globulin	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSL...	unknown	binder
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate,inducer
Solute carrier organic anion transporter family member 1A2	MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQ...	unknown	inhibitor
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL389621
PubChem	5754
ChEMBL	CHEMBL389621
ChEBI	CHEBI:17650
CCDC/CSD	ZZZPNG01, ZZZPNG03, GOGQEZ, CORTMS01, COWNEI, CORTMS, ZZZPNG02, CORTPY, SACWAY01, SACWAY, ZZZPNG04
COD	1559402