LEU

LEUCINE

Created:	1999-07-08
Last modified:	2024-09-27

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109 entries where LEU is found as a standalone ligand28 entries where LEU is covalently linked to polymer or other heterogen groups 223,239 entries where LEU is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	22
Chiral Atom Count	1
Bond Count	21
Aromatic Bond Count	0

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Chemical Component Summary
Name	LEUCINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-4-methyl-pentanoic acid
Formula	C₆ H₁₃ N O₂
Molecular Weight	131.173
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CC(C)C
SMILES	CACTVS	3.341	CC(C)C[CH](N)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	CC(C)CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	CC(C)C[C@H](N)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	CC(C)C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChIKey	InChI	1.03	ROHFNLRQFUQHCH-YFKPBYRVSA-N

Drug Info: DrugBank

DrugBank ID	DB00149
Name	Leucine
Groups	nutraceutical investigational
Description	An essential branched-chain amino acid important for hemoglobin formation.
Synonyms	L-Leucine Leucine (2S)-2-Amino-4-methylpentanoic acid (S)-(+)-Leucine (2S)-alpha-2-Amino-4-methylvaleric acid L L-Leucine hydrochloride 2-Amino-4-methylvaleric acid (2S)-alpha-Leucine L-Leuzin L-Leucin (S)-Leucine Leu
Brand Names	Premasol - sulfite-free (Amino Acid) 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 8.5% Freamine III Aminosyn II 10% With Electrolytes 4.25%travasol Amino Acid InJ.W.elecw.5%dex. 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Renamin (amino Acids) Injection Aminosyn RF Injection Aminosyn 5% Olimel 5.7% E Aminosyn II and Dextrose Nephramine Liq IV Primene 10% HepatAmine Synthamin Aminosyn II 7% Injection Aminosyn II in Dextrose Clinimix Nutrineal Pd4 Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn-PF RenAmin NephrAmine Smofkabiven Extra Nitrogen ProSol 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II 8.5% Injection Aminosyn 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn 8.5% Injection With Electrolytes Travasol Inj Without Electrolytes 5.5% 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose BranchAmin Travasol Olimel 7.6% E ProcalAmine Vamin N Aminosyn II 7% With 50% Dextrose 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Aminosyn 7% Travasol Amino Acid Inj 5.5% 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose FreAmine HBC TrophAmine Aminosyn II 8.5% With 50% Dextrose ASCE plus Derma Signal Kit SRLV S 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Aminosyn II 7% With 10% Dextrose Aminosyn II with Electrolytes Aminosyn II with Electrolytes in Dextrose with Calcium 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 10% W Electrolytes Aminosyn II In Dextrose Injection Smofkabiven Aminosyn 3.5% M Vamin 18 Electrolyte-free Plenamine Primene 10%-liq IV Smofkabiven Electrolyte Free Aminosyn Sulfite Free Essepna Aminosyn 8.5% Travasol E 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn-PF 10% 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex ExoSCRT Derma Signal SRLV Vial 1. Lyophilized 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 7.6% Smofkabiven Peripheral Hepatasol Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Primene 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix 20% Prosol Perikabiven Clinisol 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn II Periolimel 2.5% E ExoSCRT Derma Signal SRLV Vial 2. Diluent 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Kabiven 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Olimel 5.7% Olimel 4.4% E Olimel 4.4% FreAmine III ExoSCRT Derma Signal Kit SRLV Novamine Aminosyn HF Aminosyn-PF 7% Aminosyn II 5% Inj Travasol Inj Without Electrolytes 8.5% Bcaa 4% Inj Aminosyn RF Clinimix E Olimel 3.3% E ASCE plus Derma Signal Kit SRLV Travasol Amino Acid Inj 8.5%
Indication	Indicated to assist in the prevention of the breakdown of muscle proteins that sometimes occur after trauma or severe stress.
Categories	Amino Acids Amino Acids, Branched-Chain Amino Acids, Essential Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	61-90-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Probable leucine--tRNA ligase, mitochondrial	MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKE...	unknown
Leucine carboxyl methyltransferase 2	MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAP...	unknown
Leucine carboxyl methyltransferase 1	MATRQRESSITSCCSTSSCDADDEGVRGTCEDASLCKRFAVSIGYWHDPY...	unknown
Leucine--tRNA ligase, cytoplasmic	MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTF...	unknown
Branched-chain-amino-acid aminotransferase, mitochondrial	MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPG...	unknown
Branched-chain-amino-acid aminotransferase, cytosolic	MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFG...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
Monocarboxylate transporter 8	MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPE...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6106, 7045798
ChEMBL	CHEMBL291962
ChEBI	CHEBI:57427, CHEBI:15603
CCDC/CSD	CADPEF, CADPAB, CEGKOQ, GOWCAW, FEQYUW, GOWBUP, POVYUV, AXUTIX, DLLEUC02, ZIPCOT01, WAKYAJ, ZIPCOT, URODEL, SETTOB, VUKQAV01, GUQKEK, NOFWUA, HAGZUL, PATPUV, VUKQAV03, VUKQAV02, NOFXEL, NOFXAH, CADLEA, VUKQAV04, VUKQAV05, VUKQAV06, VUKQAV08, VUKQAV09, FITNIF, VUKQAV07, AHOHIQ, GOWBOJ, DLLEUC, KERMUP, YIGMIM, ZINDEI, DLLEUC03, VUKQAV, ZATMUG, ZATJOX, WIPQOE01, ZATNER, SAJYUB, ZATNAN
COD	4501604