NFL

2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID

Created: 2004-05-26
Last modified:  2021-03-01

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Chemical Details

Formal Charge0
Atom Count29
Chiral Atom Count0
Bond Count30
Aromatic Bond Count12
2D diagram of NFL

Chemical Component Summary

Name2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID
Synonyms2-[(3-TRIFLUOROMETHYL)PHENYL]AMINO-3-PYRIDINE-CARBOXYLIC ACID
Systematic Name (OpenEye OEToolkits)2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylic acid
FormulaC13 H9 F3 N2 O2
Molecular Weight282.218
TypeNON-POLYMER

Chemical Descriptors

TypeProgram Version Descriptor
SMILESACDLabs10.04FC(F)(F)c1cc(ccc1)Nc2ncccc2C(=O)O
SMILESCACTVS3.341OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F
SMILESOpenEye OEToolkits1.5.0c1cc(cc(c1)Nc2c(cccn2)C(=O)O)C(F)(F)F
Canonical SMILESCACTVS3.341 OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F
Canonical SMILESOpenEye OEToolkits1.5.0 c1cc(cc(c1)Nc2c(cccn2)C(=O)O)C(F)(F)F
InChIInChI1.03 InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
InChIKeyInChI1.03 JZFPYUNJRRFVQU-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank IDDB04552 
NameNiflumic acid
Groups experimental
DescriptionNiflumic acid is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
Synonyms
  • NFA
  • Acidum niflumicum
  • Niflumic acid
  • Acido niflumico
  • Acide niflumique
IndicationUsed in the treatment of rheumatoid arthritis.
Categories
  • Acids, Carbocyclic
  • Agents causing hyperkalemia
  • Agents that produce hypertension
  • Aminobenzoates
  • Analgesics
ATC-Code
  • M02AA17
  • M01AX02
CAS number4394-00-7

Drug Targets

NameTarget SequencePharmacological ActionActions
Phospholipase A2MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCY...unknowninhibitor
Prostaglandin G/H synthase 2MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...unknowninhibitor
Chloride channel protein ClC-KaMEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDW...unknowninducer
Prostaglandin G/H synthase 1MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFG...unknown
Cytosolic phospholipase A2MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFI...unknown
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL63323
PubChem 4488
ChEMBL CHEMBL63323
ChEBI CHEBI:34888
CCDC/CSD EXAQEA, DARGEL01, XOWKIF, DARGEL, RIQXEX, NIFLUM11
COD 4512416