NIZ

pyridine-4-carbohydrazide

Created:2010-05-21
Last modified:  2021-03-01

Help

Find related ligands:

Chemical Details

Formal Charge0
Atom Count17
Chiral Atom Count0
Bond Count17
Aromatic Bond Count6
2D diagram of NIZ
Toggle HydrogenToggle Labels

Chemical Component Summary

Namepyridine-4-carbohydrazide
Synonymsisonicotinic acid hydrazid
Systematic Name (OpenEye OEToolkits)pyridine-4-carbohydrazide
FormulaC6 H7 N3 O
Molecular Weight137.139
TypeNON-POLYMER

Chemical Descriptors

TypeProgramVersionDescriptor
SMILESACDLabs12.01O=C(NN)c1ccncc1
SMILESCACTVS3.370NNC(=O)c1ccncc1
SMILESOpenEye OEToolkits1.7.0c1cnccc1C(=O)NN
Canonical SMILESCACTVS3.370 NNC(=O)c1ccncc1
Canonical SMILESOpenEye OEToolkits1.7.0 c1cnccc1C(=O)NN
InChIInChI1.03 InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChIKeyInChI1.03 QRXWMOHMRWLFEY-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License
DrugBank IDDB00951 
NameIsoniazid
Groups
  • approved
  • investigational
DescriptionAntibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Synonyms
  • Isonicotinoylhydrazide
  • Isoniazid
  • Isonicotinsäurehydrazid
  • Isonicotinic acid hydrazide
  • Isoniazida
Brand Names
  • Isoniazid Syrup 50mg/5ml
  • IsonaRif
  • Isoniazid
  • Rifamate
  • Rifater
IndicationIsoniazid is used for the treatment of all forms of tuberculosis in which organisms are susceptible. It is also used in combination with rifampin and pyrazinamide.[L45369]
Categories
  • Agents Causing Muscle Toxicity
  • Agents that reduce seizure threshold
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antiinfectives for Systemic Use
ATC-Code
  • J04AM04
  • J04AM01
  • J04AM03
  • J04AM02
  • J04AM09
CAS number54-85-3

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License
NameTarget SequencePharmacological ActionActions
Catalase-peroxidaseMPEQHPPITETTTGAASNGCPVVGHMKYPVEGGGNQDWWPNRLNLKVLHQ...unknownother/unknown
Enoyl-[acyl-carrier-protein] reductase [NADH]MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRI...unknownadduct
Dihydrofolate reductaseMTMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWD...unknown
Arylamine N-acetyltransferase 2MDIEAYFERIGYKNSRNKLDLETLTDILEHQIRAVPFENLNMHCGQAMEL...unknownsubstrate
Arylamine N-acetyltransferaseMALDLTAYFDRINYRGATDPTLDVLQDLVTVHSRTIPFENLDPLLGVPVD...unknowninhibitor
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 6064144, 6064145, 3767
ChEMBL CHEMBL64
ChEBI CHEBI:6030
CCDC/CSD INICAC03, INICAC02, FADHEZ, FADGIC, FADGEY, FADHID, FADHAV, FADGUO, FOSFIE, BUVQER, BOMBOW, FADGOI, FADGUO02, FOSFUQ, FADGIC03, FADGUO01, FOSMIL03, FOSMIL01, ACUDAG, BICQAH, BOMBUC, BOMCAJ, ACUDEK, FADGIC02, FOSMIL, ACUDIO, FOSMIL02, INICAC04, ACUDEK01, BICQUB, FOSFOK, BIZMAZ, BICQEL, FOSFUQ01, INICAC01, COSKUT, BICQUB01, INICAC, BUQTEP
COD 2105797, 7212461, 7240290, 4512024, 4507462