PRO

PROLINE

Created:	1999-07-08
Last modified:	2024-09-27

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167 entries where PRO is found as a standalone ligand33 entries where PRO is covalently linked to polymer or other heterogen groups 224,756 entries where PRO is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	1
Bond Count	17
Aromatic Bond Count	0

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Chemical Component Summary
Name	PROLINE
Systematic Name (OpenEye OEToolkits)	(2S)-pyrrolidine-2-carboxylic acid
Formula	C₅ H₉ N O₂
Molecular Weight	115.13
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C1NCCC1
SMILES	CACTVS	3.341	OC(=O)[CH]1CCCN1
SMILES	OpenEye OEToolkits	1.5.0	C1CC(NC1)C(=O)O
Canonical SMILES	CACTVS	3.341	OC(=O)[C@@H]1CCCN1
Canonical SMILES	OpenEye OEToolkits	1.5.0	C1C[C@H](NC1)C(=O)O
InChI	InChI	1.03	InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
InChIKey	InChI	1.03	ONIBWKKTOPOVIA-BYPYZUCNSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00172
Name	Proline
Groups	nutraceutical
Description	Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons.
Synonyms	L-α-pyrrolidinecarboxylic acid L-alpha-pyrrolidinecarboxylic acid Prolina L-Proline Proline (−)-(S)-proline (−)-2-pyrrolidinecarboxylic acid (2S)-pyrrolidine-2-carboxylic acid L-(−)-proline (S)-pyrrolidine-2-carboxylic acid (-)-2-Pyrrolidinecarboxylic acid (−)-proline L-Prolina P L-Prolin L-pyrrolidine-2-carboxylic acid (S)-2-Carboxypyrrolidine (S)-2-Pyrrolidinecarboxylic acid Prolinum 2-Pyrrolidinecarboxylic acid
Brand Names	Aminosyn 10% W Electrolytes Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn II Aminosyn-PF 10% 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Clinimix Olimel 5.7% E Travasol Inj Without Electrolytes 5.5% Kabiven Plenamine 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Smofkabiven Extra Nitrogen Primene Smofkabiven Nutrineal Pd4 Primene 10%-liq IV Essepna Aminosyn 8.5% Aminosyn II 7% Injection Aminosyn II with Electrolytes RenAmin Periolimel 2.5% E 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Vamin N Primene 10% Aminosyn-PF 7% Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Travasol Amino Acid Inj 8.5% Hepatasol Clinisol Aminosyn 5% Olimel 5.7% Aminosyn II 5% Inj 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Travasol Amino Acid Inj 5.5% TrophAmine Aminosyn II In Dextrose Injection Perikabiven 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn II and Dextrose Aminosyn-PF Travasol E Olimel 4.4% E 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Aminosyn 8.5% Injection With Electrolytes Olimel 7.6% E 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn Sulfite Free 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Novamine FreAmine III Aminosyn HF Aminosyn 3.5% M FreAmine HBC 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 20% Prosol 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn Synthamin 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Renamin (amino Acids) Injection Vamin 18 Electrolyte-free 4.25%travasol Amino Acid InJ.W.elecw.5%dex. HepatAmine Aminosyn II 10% With Electrolytes Aminosyn II 7% With 10% Dextrose Aminosyn II 8.5% Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Olimel 7.6% Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II 8.5% With 50% Dextrose Smofkabiven Electrolyte Free Olimel 3.3% E 8.5% Freamine III 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn II 7% With 50% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Travasol 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix ProcalAmine 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Clinimix E Travasol Inj Without Electrolytes 8.5% Premasol - sulfite-free (Amino Acid) Olimel 4.4% Aminosyn II in Dextrose 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn 7% ProSol
Indication	L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles.
Categories	Amino Acids Amino Acids, Cyclic Amino Acids, Peptides, and Proteins Dietary Supplements Imino Acids Proteinogenic Amino Acids Supplements
CAS number	147-85-3

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Peptidyl-prolyl cis-trans isomerase B	MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDL...	unknown	binder
Peptidyl-prolyl cis-trans isomerase A	MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKG...	unknown	binder
Pyrroline-5-carboxylate reductase 1, mitochondrial	MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGV...	unknown
Bifunctional glutamate/proline--tRNA ligase	MATLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENILHVSENVIFTD...	unknown
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMI...	unknown
Sodium-dependent proline transporter	MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSC...	unknown
Pyrroline-5-carboxylate reductase 2	MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGV...	unknown
Prolyl 4-hydroxylase subunit alpha-2	MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILV...	unknown
Proline dehydrogenase 1, mitochondrial	MALRRALPALRPCIPRFVPLSTAPASREQPAAGPAAVPGGGSATAVRPPV...	unknown
Peptidyl-prolyl cis-trans isomerase H	MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGE...	unknown
Pyridoxal phosphate homeostasis protein	MWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKP...	unknown
Prolyl 4-hydroxylase subunit alpha-1	MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEE...	unknown
Peptidyl-prolyl cis-trans isomerase F, mitochondrial	MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYL...	unknown
Peptidyl-prolyl cis-trans isomerase C	MGPGPRLLLPLVLCVGLGALVFSSGAEGFRKRGPSVTAKVFFDVRIGDKD...	unknown
Peptidyl-prolyl cis-trans isomerase G	MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGT...	unknown
Prolyl 3-hydroxylase 1	MAVRALKLLTTLLAVVAAASQAEVESEAGWGMVTPDLLFAEGTAAYARGD...	unknown
Pyrroline-5-carboxylate reductase	MSVGFIGAGQLAMLWRGASRPQIPVGSQDNSQLPRNEPAHGVRAQEDGCE...	unknown
Probable proline--tRNA ligase, mitochondrial	MEGLLTRCRALPALATCSRQLSGYVPCRFHHCAPRRGRRLLLSRVFQPQN...	unknown
Prolyl 3-hydroxylase 2	MRERIWAPPLLLLLPLLLPPPLWGGPPDSPRRELELEPGPLQPFDLLYAS...	unknown
Prolyl 3-hydroxylase 3	MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAA...	unknown
Pyrroline-5-carboxylate reductase 3	MAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCH...	unknown
Trans-3-hydroxy-L-proline dehydratase	MESALAVPRLPPHDPGTPVLSVVDMHTGGEPLRIVLAGCPEVSGPTLLAK...	unknown
Proline dehydrogenase 1, mitochondrial	MALRRALPALRPCIPRFVPLSTAPASREQPAAGPAAVPGGGSATAVRPPV...	unknown	substrate
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682