RFZ

5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole

Created:	2007-10-19
Last modified:	2011-06-04

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3 entries where RFZ is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	32
Chiral Atom Count	4
Bond Count	34
Aromatic Bond Count	10

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Chemical Component Summary
Name	5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole
Systematic Name (OpenEye OEToolkits)	(2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Formula	C₁₂ H₁₂ Cl₂ N₂ O₄
Molecular Weight	319.141
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc2cc1ncn(c1cc2Cl)C3OC(C(O)C3O)CO
SMILES	CACTVS	3.341	OC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3cc(Cl)c(Cl)cc23
SMILES	OpenEye OEToolkits	1.5.0	c1c2c(cc(c1Cl)Cl)n(cn2)C3C(C(C(O3)CO)O)O
Canonical SMILES	CACTVS	3.341	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1c2c(cc(c1Cl)Cl)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O
InChI	InChI	1.03	InChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
InChIKey	InChI	1.03	XHSQDZXAVJRBMX-DDHJBXDOSA-N

Drug Info: DrugBank

DrugBank ID	DB08473
Name	Dichlororibofuranosylbenzimidazole
Groups	experimental
Synonyms	5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole Dichlororibofuranosylbenzimidazole
Categories	Enzyme Inhibitors Nucleic Acid Synthesis Inhibitors Nucleic Acids, Nucleotides, and Nucleosides Nucleosides Ribonucleosides
CAS number	53-85-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Casein kinase II subunit alpha	MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKY...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682