SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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120 entries where SER is found as a standalone ligand52 entries where SER is covalently linked to polymer or other heterogen groups 238,793 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	L-Serine (S)-Serine beta-Hydroxyalanine Serine Ser alpha-Amino-beta-hydroxypropionic acid Serinum (S)-2-Amino-3-hydroxypropanoic acid Serina
Brand Names	Perikabiven Aminosyn II 10% With Electrolytes Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn 3.5% M Renamin (amino Acids) Injection Aminosyn HF Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Premasol - sulfite-free (Amino Acid) Aminosyn-PF Primene 8.5% Freamine III Aminosyn 5% 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II in Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Clinisol Smofkabiven Extra Nitrogen Electrolyte Free Synthamin Aminosyn II with Electrolytes HepatAmine Olimel 4.4% ProcalAmine Primene 10%-liq IV Aminosyn 7% Aminosyn Aminosyn II 7% Injection Olimel 7.6% E 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II 7% With 50% Dextrose Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn II and Dextrose Travasol Olimel 4.4% E 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 20% Prosol Aminosyn II Olimel 7.6% Periolimel 2.5% E Primene 10% Hepatasol Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Clinimix Aminosyn Sulfite Free Aminosyn 8.5% Aminosyn-PF 10% Olimel 3.3% E 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Aminosyn-PF 7% RenAmin Aminosyn II 5% Inj 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Olimel 5.7% E 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Essepna Olimel 5.7% Plenamine Clinimix E ProSol Aminosyn 10% W Electrolytes 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Nutrineal Pd4 FreAmine HBC Novamine Aminosyn II 8.5% Injection Smofkabiven Smofkabiven Extra Nitrogen FreAmine III Smofkabiven Electrolyte Free Aminosyn II In Dextrose Injection Vamin 18 Electrolyte-free Kabiven Aminosyn 8.5% Injection With Electrolytes Vamin N Aminosyn II 8.5% With 50% Dextrose Smofkabiven Peripheral Aminosyn II 7% With 10% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex. TrophAmine
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6857581, 5951
ChEMBL	CHEMBL11298
ChEBI	CHEBI:33384, CHEBI:17115
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01