A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Synonyms
Theophylline anhydrous
Theophylline sodium glycinate
Teofilina
Theophylline, anhydrous
1,3-dimethylxanthine
Theophylline
1,3-dimethyl-7H-purine-2,6-dione
Theophyllin
Brand Names
Tedral Tab
Teva-theophylline SR
Theochron Srt 200mg
Uniphyl
Theophylline in Dextrose
Theolair SR Tab 200mg
Theophylline 0.8mg and 5% Dextrose Inj
Theophylline Anhydrous
Theophylline Elixir
Theo-dur 300 mg
Elixophyllin
Theochron Srt 300mg
Theophylline 80mg/15ml
Slo-bid 50
Theolair Tab 125mg
Theolair SR Tab 300mg
Theophylline Rougier Elixir
Theolair SR Tab 250mg
Theolair Tab 250mg
Theophylline 1.6mg and 5% Dextrose Inj
Aa-theo LA
Senophylline
Theophylline Extended Release
Theophylline
Theo-24
Theo-dur 100 mg
Theo-dur 200 mg
Quibron-T
Quibron T/SR
Slo-bid 300
Idm Tab
PMS-theophylline Elixir
Slo-bid 200
Ratio-theo-bronc
Theophylline(Anhydrous)
Theo-dur 450 mg
Pulmophylline Elx
Theo-SR 300 Srt 300mg
Theophylline Elx
Theochron Srt 100mg
Theolair SR Tab 500mg
Theophylline 4mg and 5% Dextrose Inj
Theo ER
Quibron T SR Tab 300mg
Theophylline (Anhydrous)
Theophylline 0.8mg/ml In 5% Dextrose Inj
Theolair
Elixir De Theophylline
Apo-theo ER
I D M Expectorant Tab
Slo-bid 100
Indication
For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
Categories
Agents that reduce seizure threshold
Alkaloids
Anti-Asthmatic Agents
Autonomic Agents
Bronchodilator Agents
Cardiovascular Agents
Cytochrome P-450 CYP1A2 Substrates
Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2C8 Substrates
Cytochrome P-450 CYP2D6 Substrates
Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2E1 Substrates
Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP3A Substrates
Cytochrome P-450 CYP3A4 Substrates
Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682