TIZ

(1R)-1-[4-(AMINOCARBONYL)-1,3-THIAZOL-2-YL]-1,4-ANHYDRO-D-RIBITOL

Created:	2007-03-08
Last modified:	2021-03-01

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2 entries where TIZ is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	29
Chiral Atom Count	0
Bond Count	30
Aromatic Bond Count	0

2D diagram of TIZ

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Chemical Component Summary
Name	(1R)-1-[4-(AMINOCARBONYL)-1,3-THIAZOL-2-YL]-1,4-ANHYDRO-D-RIBITOL
Synonyms	TIAZOFURIN
Systematic Name (OpenEye OEToolkits)	2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
Formula	C₉ H₁₂ N₂ O₅ S
Molecular Weight	260.267
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(c1nc(sc1)C2OC(C(O)C2O)CO)N
SMILES	CACTVS	3.341	NC(=O)c1csc(n1)[CH]2O[CH](CO)[CH](O)[CH]2O
SMILES	OpenEye OEToolkits	1.5.0	c1c(nc(s1)C2C(C(C(O2)CO)O)O)C(=O)N
Canonical SMILES	CACTVS	3.341	NC(=O)c1csc(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1c(nc(s1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N
InChI	InChI	1.03	InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1
InChIKey	InChI	1.03	FVRDYQYEVDDKCR-DBRKOABJSA-N

Drug Info: DrugBank

DrugBank ID	DB13243
Name	Tiazofurine
Groups	experimental
Description	Tiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5’-monophosphate (IMP) dehydrogenase [A174991].
Synonyms	2-Beta-D-ribofuranosyl-4-thiazolecarboxamide Tiazofurinum 2-(β-D-ribofuranosyl)-4-thiazolecarboxamide Tiazofurine TCAR 2-β-D-ribofuranosyl-4-thiazolecarboxamide Tiazofurina Tiazofurin
Categories	Antimetabolites Antineoplastic Agents Antineoplastic and Immunomodulating Agents Noxae Nucleic Acids, Nucleotides, and Nucleosides Nucleosides Ribonucleosides Toxic Actions
ATC-Code	L01XX18
CAS number	60084-10-8

Related Resource References

Resource Name	Reference
PubChem	457954
ChEMBL	CHEMBL108358
ChEBI	CHEBI:90239
CCDC/CSD	BOBNEL10

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.