Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
Trinitrine
Glycerol, nitric acid triester
Nitroglycerin
Nitroglycerine
Nitroglicerina
Trinitroglycerin
Propane-1,2,3-triyl trinitrate
Glycerin trinitrate
Glycerol trinitrate
Glyceryl trinitrate
Nitroglycerol
Glyceroltrinitrat
Glyceroli trinitratis
NG
1,2,3-propanetrioltrinitrate
Nitromed
1,2,3-propanetriyl nitrate
Trinitroglycerol
Brand Names
Nitroglycerin In Dextrose
Transderm-nitro 0.6
Mylan-nitro Patch 0.6
NitroMist
Apo-nitroglycerin
Nitro-dur 0.8
Trinipatch 0.6
Basic Dental Emergency Kit
Transderm-nitro 0.2
Rho-nitro Pumpspray
Nitro-dur 0.6
Nitro-dur 0.4
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Nitrol
Nitro-dur
Nitroglycerin Transdermal Delivery System
Transderm Nitro
Trinipatch 0.2
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Nitrong SR Srt 2.6mg
Nitroglycerin Injection USP
Nitrolingual Spray 0.4mg/eam
Mylan-nitro Patch 0.2
Nitro-Time
Deluxe Dental Emergency Kit
Transderm-nitro 0.8
Nitroglycerin Transdermal System
Tridil Injection 5mg/ml
Nitroject Inj 1mg/ml
Nitro-dur 0.2
Trinipatch 0.4
Nitroglycerin Inj 5mg/ml
Nitroject
Nitroglycerin SR
Nitrolingual Pumpspray
Transderm-nitro 0.4
Nitro-bid
Minitran
Nitroglycerin in Dextrose
Mylan-nitro Patch 0.4
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Nitrolingual
Mylan-nitro Sublingual Spray
Nitroglycerin
Rectiv
Nitroglycerin Transdermal Infusion System
Nitroglycerin ER
Nitronal
Nitrogard-SR Tab 1mg
Gonitro
Minitran - Patch Trd 72mg/26.6 Sq Cm
Mylan-nitro Patch 0.8
Nitroglycerin Lingual
Nitrostat
Nitro-time
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Nitroglycerin Slocaps
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
