U10

UBIQUINONE-10

Created:	1999-07-08
Last modified:	2020-06-05

Find Related PDB Entry
203 entries where U10 is found as a standalone ligand

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	153
Chiral Atom Count	0
Bond Count	153
Aromatic Bond Count	0

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	UBIQUINONE-10
Synonyms	Coenzyme Q10
Systematic Name (OpenEye OEToolkits)	2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione
Formula	C₅₉ H₉₀ O₄
Molecular Weight	863.343
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C1C(=C(C(=O)C(OC)=C1OC)C)C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)C
SMILES	CACTVS	3.341	COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
SMILES	OpenEye OEToolkits	1.5.0	CC1=C(C(=O)C(=C(C1=O)OC)OC)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
Canonical SMILES	CACTVS	3.341	COC1=C(OC)C(=O)C(=C(C)C1=O)C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C
Canonical SMILES	OpenEye OEToolkits	1.5.0	CC1=C(C(=O)C(=C(C1=O)OC)OC)C\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
InChI	InChI	1.03	InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
InChIKey	InChI	1.03	ACTIUHUUMQJHFO-UPTCCGCDSA-N

Drug Info: DrugBank

DrugBank ID	DB09270
Name	Ubidecarenone
Groups	approved nutraceutical investigational
Description	Ubidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of isoprenyl subunits in its tail.[A7874] It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation.[A31413] The ubidecarenone is the coenzyme destined for mitochondrial enzyme complexes involved in oxidative phosphorylation in the production of ATP. It is fundamental for cells that have a high metabolic demand.[L1062] Ubidecarenone is sold as a dietary supplement and is not FDA approved as a drug - it is not meant to treat, cure or prevent any disease. FDA does not approve this dietary supplements before sold nor regulate the manufacturing process.[L1063]
Synonyms	Coenzyme q10, (2z)- Coenzyme Q10 Vitamin Q10 CoQ10 Coenzyme Q-10 Ubiquinone Ubidecarenone
Brand Names	Coenzyme Q10 60mg Capsules Now Coq10 100 mg Xyzbac G N.E.U. Complex Coq10 Lexazin C.V. Formula Vitazyme Folica-V PROTECT IRON Liquid Co-Q 10 Capsules 50 mg Formula Statin Support Zyvit Formula S.E. Coenzyme Q10 100mg Coenzyme Q10 Tab 10mg Coen.q10w.vit.c and E Beta-car.se Cu Zn Mn Coenzyme Co Q10 Cap 30mg Folica BE Co-enzyme Q10 60 mg Vita-Rx Diabetic Vitamin N.U.T. Complex Formula Cp Cap Biosculpt tensioSAN CoQ10 200mg Coenzyme Co Q10 Cap 10mg Daily Supplement Packs Protect Plus SO 60 Acti-ubiquinone 50 Cap 50mg Coenzyme Q10 Nicadan ZX Coq-10 VitaXyme Dayavite Fibrik Extra 11 Oveeza Vitamin E and Coq10 Watkins Coq10 Taliment Co-q10 30mg (ubiquinone) Coquinone Coenzyme Q-10 Capsules Coenzyme Q10 80mg Corvite Free Qmelt Cell Tech Coenzyme Q10 - Cap 30mg IQQU Acne Serum Rocky Mountain Co Q 10 Cap 25mg Q-10 Extra -cap Coenzyme Q10 Cap 30mg Protect Cardio AF Folic-K Super 7 Vitamin and Mineral Supplement Coenzyme Q10 - 10mg (ubiquinone) Biomed Co Q 10 Q-gel Forte Coenzyme Q10 Coenzyme Q10 100 mg Coenzyme Q10 - Capsule 30 mg Co Q 10 - 50mg Cap Neutral C + Coenzyme Q10 - Cap Folika-V Co-q10 Cap 30mg Thera Q Plus Co-q10 - Cap 60mg Coq10 With E400 Iu Omniquin Co-q10 30mg Formula Dpr Q-10 Plus Nutri-chem Coenzyme Q10 20mg Formula B Co-enzyme Q10 100mg Q-gel Coenzyme Q10 Xyzbac Coenzyme-q10 M.R.B. Coenzyme Q10 60mg Coenzyme Q10 With Hawthorn Extract and Citrus Bioflavonoids Nutra-Z Amladex Coenzyme Q-10 Genicin Vita-Q Co-Q-10 Capsules 30mg Cellsparc 360 Coenzyme Q10 - 30mg (ubiquinone) Coenzyme Q-10 60 mg Coenzyme Q10 Isotonix Vitamin and Mineral Supplement Coenzyme Q10 50 mg B.E.T. Complex Omnivex Co-q10 60 Mg Capsules Co-q10 M.R.B. 100mg and Vitamin E L.I.P. Complex Medi-10 Co-enzyme Q10 30mg Capsules Coenzyme Q10 30 mg Ubiquinone Capsules 20mg Mebolex Coenzyme Q-10 - 30 mg Biogard Ubiquinone Cap 30mg Co-q10 and Vitamin E Formula O.C. Co-enzyme Q10 60mg Capsules PreQue 10 Coenzyme Q10 + Coenzyme Q10 30mg Coenzyme Q10 Cap 15mg Methazel Coenzyme Q10 50mg Co-enzyme Q10 50mg Capsules Tru-sorb Coq10 Co-enzyme-q10 Tab Co-enzyme Q-10 Dyzbac Coenzyme Q10 (60 Mg) Co-q10 (ubiquinone) Co-q10 M.R.B. 60mg Co-enzyme Q-10 Capsules Usana Optimizer Coquinone Coenzyme Q-10 Capsules Coenzyme Q10 60mg Cap Neutral C + Coenzyme Q10 Plus Vitamins & Minerals Mebolic Zavitrol Co-enzyme Q10 Cap 30mg Coenzyme Q10 Ubiquinone 60mg - Cap
Indication	The diet supplements containing ubidecarenone are indicated, as stated in the product label, to assist individuals with cardiovascular complaints including congestive heart failure and systolic hypertension. In the product, ubidecarenone is used to increase the cardiac input as well as for the prevention of several other diseases like Parkinson, fibromyalgia, migraine, periodontal disease and diabetes, based on preclinical studies.[L1064] It is important to highlight that these products are not FDA approved and it is recommended to use under discretion.
Categories	Agents Causing Muscle Toxicity Benzoquinones Cardiac Therapy Coenzymes Diet, Food, and Nutrition Electron Transport Chain Complex Proteins Enzymes and Coenzymes Food Hypoglycemia-Associated Agents Micronutrients Other Nutritional Agents P-glycoprotein substrates Physiological Phenomena Quinones Ubiquinone Vitamins
ATC-Code	C01EB09
CAS number	303-98-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSK...	unknown	cofactor
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDS...	unknown	cofactor
3-hydroxy-3-methylglutaryl-coenzyme A reductase	MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYEC...	unknown	substrate
Low-density lipoprotein receptor	MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSA...	unknown	substrate
Very low-density lipoprotein receptor	MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLW...	unknown	substrate
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682