URC

URIC ACID

Created:	2002-03-15
Last modified:	2021-03-13

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35 entries where URC is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	16
Chiral Atom Count	0
Bond Count	17
Aromatic Bond Count	10

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Chemical Component Summary
Name	URIC ACID
Synonyms	7,9-DIHYDRO-1H-PURINE-2,6,8(3H)-TRIONE
Systematic Name (OpenEye OEToolkits)	7,9-dihydro-3H-purine-2,6,8-trione
Formula	C₅ H₄ N₄ O₃
Molecular Weight	168.11
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C1C2=C(NC(=O)N1)NC(=O)N2
SMILES	CACTVS	3.341	O=C1NC(=O)C2=C(N1)NC(=O)N2
SMILES	OpenEye OEToolkits	1.5.0	C12=C(NC(=O)N1)NC(=O)NC2=O
Canonical SMILES	CACTVS	3.341	O=C1NC(=O)C2=C(N1)NC(=O)N2
Canonical SMILES	OpenEye OEToolkits	1.5.0	C12=C(NC(=O)N1)NC(=O)NC2=O
InChI	InChI	1.03	InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
InChIKey	InChI	1.03	LEHOTFFKMJEONL-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB08844
Name	Uric acid
Groups	investigational
Description	Uric acid is the last product of purine metabolism in humans. The formation of uric acid is through the enzyme xanthine oxidase, which oxidizes oxypurines. Normally a small amount of uric acid is present in the body, but when there is an excess amount in the blood, called hyperuricemia, this can lead to gout and formation of kidney stones. As a therapeutic agent, it is known that uric acid is increased in response to oxidative stress, and as such, uric acid acts as an antioxidant. At present (August 2013), there is no approved formulation or indication for uric acid. In one country, Spain, uric acid is an investigational drug in a phase 3 trial studying its effects as an adjunct to alteplase in acute ischemic stroke.
Synonyms	Uric acid Lithic acid Purine-2,6,8(1H,3H,9H)-trione Urate 2,6,8-trihydroxypurine 7,9-dihydro-1H-purine-2,6,8(3H)-trione Uricum acidum 2,6,8-trioxopurine 2,6,8-trioxypurine
Indication	At present (August 2013), there is no approved indication for uric acid. The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke.
Categories	Alkaloids Antioxidants Biological Factors Compounds used in a research, industrial, or household setting Heterocyclic Compounds, Fused-Ring Protective Agents Purines Purinones Xanthine derivatives
CAS number	69-93-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Glycogen phosphorylase, liver form	-	unknown
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown
Solute carrier family 22 member 8	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown
Solute carrier family 2, facilitated glucose transporter member 9	MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRK...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	1175, 5274273
ChEMBL	CHEMBL792
ChEBI	CHEBI:46823, CHEBI:62589, CHEBI:46814, CHEBI:46811, CHEBI:17775, CHEBI:46817
CCDC/CSD	URICAC, URICAC06, URICAC05, URICAC04, URICAC03, URICAC02, GADGIF, URICAC01