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235,458 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Abu-Omar, M.M."

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Search Summary

This query matches 58 Structures.

Refinements

Structure Determination Methodology

experimental (58)

Scientific Name of Source Organism

	Human alphaherpesvirus 1 strain 17 (58)
	Homo sapiens (8)
	Bacillus phage PZA (1)
	Human alphaherpesvirus 1 (1)
	Staphylococcus aureus (1)
	Takahashivirus PBS1 (1)

Taxonomy

	Duplodnaviria (58)
	Eukaryota (8)
	Bacteria (1)

Experimental Method

	X-RAY DIFFRACTION (48)
	ELECTRON MICROSCOPY (5)
	SOLUTION NMR (5)

Polymer Entity Type

	Protein (58)
	DNA (1)

Refinement Resolution (Å)

	1.5 - 2.0 (10)
	2.0 - 2.5 (24)
	2.5 - 3.0 (10)
	3.0 - 3.5 (2)
	3.5 - 4.0 (6)
	> 4.5 (1)

Release Date

	1995 - 1999 (12)
	2000 - 2004 (9)
	2005 - 2009 (3)
	2010 - 2014 (12)
	2015 - 2019 (13)
	2020 - 2024 (9)

Enzyme Classification Name

	Transferases (34)
	Hydrolases (16)

Symmetry Type

	Cyclic (37)
	Asymmetric (23)
	Dihedral (1)

SCOP Classification

	Alpha and beta proteins (a/b) (33)
	Artifacts (3)
	Alpha and beta proteins (a+b) (2)
	All alpha proteins (1)
	All beta proteins (1)
	Peptides (1)

AllSelected

1 to 25 of 58 Structures

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1E2H \| pdb_00001e2h	Download File View File

The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography

Vogt, J., Scapozza, L., Schulz, G.E.

(2000) Proteins 41: 545

Released	2000-11-06
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	SO4

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1E2I \| pdb_00001e2i	Download File View File

The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography

Vogt, J., Scapozza, L., Schulz, G.E.

(2000) Proteins 41: 545

Released	2000-11-06
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	APS, ARP, SO4

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1E2J \| pdb_00001e2j	Download File View File

The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography

Vogt, J., Scapozza, L., Schulz, G.E.

(2000) Proteins 41: 545

Released	2000-11-06
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	SO4, THM

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1E2K \| pdb_00001e2k	Download File View File

Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine

Vogt, J., Scapozza, L., Schulz, G.E.

(2000) Biochemistry 39: 9597

Released	2000-08-19
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	SO4, TMC

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1E2L \| pdb_00001e2l	Download File View File

Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine

Vogt, J., Scapozza, L., Schulz, G.E.

(2000) Biochemistry 39: 9597

Released	2000-08-18
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	SO4, TMC

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1E2M \| pdb_00001e2m	Download File View File

HPT + HMTT

Vogt, J., Scapozza, L., Schulz, G.E.

(2001) Protein Sci 10: 63

Released	2001-03-31
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	HPT, SO4

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1E2N \| pdb_00001e2n	Download File View File

HPT + HMTT

Vogt, J., Scapozza, L., Schulz, G.E.

(2001) Protein Sci 10: 63

Released	2001-03-31
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	RCA, SO4

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1KI2 \| pdb_00001ki2	Download File View File

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR

Champness, J.N., Bennett, M.S., Wien, F., Brown, D.G., Visse, R., Sandhu, G., Davies, A., Rizkallah, P.J., Melitz, C., Summers, W.C., Sanderson, M.R.

(1998) Proteins 32: 350-361

Released	1998-12-02
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	GA2, SO4

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1KI3 \| pdb_00001ki3	Download File View File

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH PENCICLOVIR

Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Jarvest, R.L., Summers, W.C., Sanderson, M.R.

(1998) Proteins 32: 350-361

Released	1999-05-18
Method	X-RAY DIFFRACTION 2.37 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	PE2, SO4

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1KI4 \| pdb_00001ki4	Download File View File

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOTHIENYLDEOXYURIDINE

Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Sanderson, M.R.

(1998) Proteins 32: 350-361

Released	1998-12-02
Method	X-RAY DIFFRACTION 2.34 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	BTD, SO4

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1KI6 \| pdb_00001ki6	Download File View File

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH A 5-IODOURACIL ANHYDROHEXITOL NUCLEOSIDE

Champness, J.N., Bennett, M.S., Wien, F., Herdewijn, P., Ostrowski, T., Summers, W.C., Sanderson, M.R.

(1998) Proteins 32: 350-361

Released	1998-12-02
Method	X-RAY DIFFRACTION 2.37 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	AHU, SO4

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1KI7 \| pdb_00001ki7	Download File View File

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-IODODEOXYURIDINE

Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Sanderson, M.R.

(1998) Proteins 32: 350-361

Released	1998-12-02
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	ID2, SO4

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1KI8 \| pdb_00001ki8	Download File View File

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOVINYLDEOXYURIDINE

Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Sanderson, M.R.

(1998) Proteins 32: 350-361

Released	1998-12-02
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	BVD, SO4

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1KIM \| pdb_00001kim	Download File View File

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH DEOXYTHYMIDINE

Champness, J.N., Bennett, M.S., Wien, F., Brown, D.G., Visse, R., Sandhu, G., Davies, A., Rizkallah, P.J., Melitz, C., Summers, W.C., Sanderson, M.R.

(1998) Proteins 32: 350-361

Released	1998-05-20
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	SO4, THM

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1OF1 \| pdb_00001of1	Download File View File

KINETICS AND CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (SOUTH)-METHANOCARBA-THYMIDINE

Claus, M.T., Schelling, P., Folkers, G., Marquez, V.E., Scapozza, L., Schulz, G.E.

(2004) J Biological Chem 279: 32832

Released	2004-06-03
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	THYMIDINE KINASE (protein)
Unique Ligands	SCT, SO4

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1P7C \| pdb_00001p7c	Download File View File

Crystal Structure of HSV1-TK complexed with TP5A

Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.

(2003) Structure 11: 1265-1277

Released	2003-11-04
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	Thymidine kinase (protein)
Unique Ligands	SO4, T5A, THM

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1QHI \| pdb_00001qhi	Download File View File

HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE

Bennett, M.S., Wien, F., Champness, J.N., Batuwangala, T., Rutherford, T., Summers, W.C., Sun, H., Wright, G., Sanderson, M.R.

(1999) FEBS Lett 443: 121-125

Released	1999-07-09
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	PROTEIN (THYMIDINE KINASE) (protein)
Unique Ligands	BPG, SO4

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1QLO \| pdb_00001qlo	Download File View File

Structure of the active domain of the herpes simplex virus protein ICP47 in water/sodium dodecyl sulfate solution determined by nuclear magnetic resonance spectroscopy

Pfaender, R., Neumann, L., Zweckstetter, M., Seger, C., Holak, T.A., Tampe, R.

(1999) Biochemistry 38: 13692

Released	1999-12-14
Method	SOLUTION NMR
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	HERPES SIMPLEX VIRUS PROTEIN ICP47 (protein)

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1UDG \| pdb_00001udg	Download File View File

THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE

Pearl, L.H., Savva, R.

(1995) Nature 373: 487-493

Released	1996-01-29
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	URACIL-DNA GLYCOSYLASE (protein)
Unique Ligands	SO4

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1UDH \| pdb_00001udh	Download File View File

THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE

Pearl, L.H., Savva, R.

(1995) Nature 373: 487-493

Released	1996-03-08
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	URACIL-DNA GLYCOSYLASE (protein)
Unique Ligands	SO4, URA

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1UDI \| pdb_00001udi	Download File View File

NUCLEOTIDE MIMICRY IN THE CRYSTAL STRUCTURE OF THE URACIL-DNA GLYCOSYLASE-URACIL GLYCOSYLASE INHIBITOR PROTEIN COMPLEX

Pearl, L.H., Savva, R.

(1995) Nat Struct Biol 2: 752-757

Released	1996-03-08
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Human alphaherpesvirus 1 strain 17 Takahashivirus PBS1
Macromolecule	URACIL-DNA GLYCOSYLASE (protein) URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN (protein)

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2PHE \| pdb_00002phe	Download File View File

Model for VP16 binding to PC4

Jonker, H.R.A., Wechselberger, R.W., Boelens, R., Folkers, G.E., Kaptein, R.

(2005) Biochemistry 44: 827-839

Released	2007-04-24
Method	SOLUTION NMR
Organisms	Homo sapiens Human alphaherpesvirus 1 strain 17
Macromolecule	Alpha trans-inducing protein (protein) TRANSCRIPTIONAL COACTIVATOR PC4 (protein)

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2PHG \| pdb_00002phg	Download File View File

Model for VP16 binding to TFIIB

Jonker, H.R.A., Wechselberger, R.W., Boelens, R., Folkers, G.E., Kaptein, R.

(2005) Biochemistry 44: 827-839

Released	2007-04-24
Method	SOLUTION NMR
Organisms	Homo sapiens Human alphaherpesvirus 1 strain 17
Macromolecule	Alpha trans-inducing protein (protein) Transcription initiation factor IIB (protein)

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3F0T \| pdb_00003f0t	Download File View File

Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT

Pernot, L., Perozzo, R., Westermaier, Y., Martic, M., Ametamey, S., Scapozza, L.

(2011) Nucleosides Nucleotides Nucleic Acids 30: 293-315

Released	2009-11-03
Method	X-RAY DIFFRACTION 2 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	Thymidine kinase (protein)
Unique Ligands	NCV, SO4

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3RDP \| pdb_00003rdp	Download File View File

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with N-METHYL-FHBT

Pernot, L., Perozzo, R., Westermaier, Y., Martic, M., Ametamey, S., Scapozza, L.

(2011) Nucleosides Nucleotides Nucleic Acids 30: 293-315

Released	2011-08-03
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Human alphaherpesvirus 1 strain 17
Macromolecule	Thymidine kinase (protein)
Unique Ligands	NMF, SO4

1 to 25 of 58 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1E2H | pdb_00001e2h

1E2I | pdb_00001e2i

1E2J | pdb_00001e2j

1E2K | pdb_00001e2k

1E2L | pdb_00001e2l

1E2M | pdb_00001e2m

1E2N | pdb_00001e2n

1KI2 | pdb_00001ki2

1KI3 | pdb_00001ki3

1KI4 | pdb_00001ki4

1KI6 | pdb_00001ki6

1KI7 | pdb_00001ki7

1KI8 | pdb_00001ki8

1KIM | pdb_00001kim

1OF1 | pdb_00001of1

1P7C | pdb_00001p7c

1QHI | pdb_00001qhi

1QLO | pdb_00001qlo

1UDG | pdb_00001udg

1UDH | pdb_00001udh

1UDI | pdb_00001udi

2PHE | pdb_00002phe

2PHG | pdb_00002phg

3F0T | pdb_00003f0t

3RDP | pdb_00003rdp