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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Cassar-Lajeunesse, E."

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Search Summary

This query matches 19 Structures.

Refinements

Structure Determination Methodology

experimental (19)

Scientific Name of Source Organism

Homo sapiens (19)

Taxonomy

Eukaryota (19)

Experimental Method

X-RAY DIFFRACTION (19)

Polymer Entity Type

Protein (19)

Refinement Resolution (Å)

	1.0 - 1.5 (6)
	1.5 - 2.0 (10)
	2.0 - 2.5 (2)
	2.5 - 3.0 (1)

Release Date

	2010 - 2014 (17)
	2015 - 2019 (2)

Enzyme Classification Name

Hydrolases (19)

Symmetry Type

	Asymmetric (15)
	Cyclic (5)

SCOP Classification

	Alpha and beta proteins (a+b) (17)
	Artifacts (9)

AllSelected

1 to 19 of 19 Structures

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3TVC \| pdb_00003tvc	Download File View File

Human MMP13 in complex with L-glutamate motif inhibitor

Stura, E.A., Dive, V., Devel, L., Czarny, B., Beau, F., Vera, L., Cassar-Lajeunesse, E.

(2012) J Biological Chem 287: 26647-26656

Released	2012-06-20
Method	X-RAY DIFFRACTION 2.43 Å
Organisms	Homo sapiens
Macromolecule	Collagenase 3 (protein)
Unique Ligands	CA, E3P, PEG, ZN

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4GQL \| pdb_00004gql	Download File View File

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470.1

Stura, E.A., Vera, L., Beau, F., Devel, L., Cassar-Lajeunesse, E., Dive, V.

(2013) J Med Chem 56: 1149-1159

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.15 Å
Organisms	Homo sapiens
Macromolecule	Macrophage metalloelastase (protein)
Unique Ligands	CA, R47, ZN

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4GR0 \| pdb_00004gr0	Download File View File

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B

Stura, E.A., Vera, L., Beau, F., Devel, L., Cassar-Lajeunesse, E., Dive, V.

(2013) J Med Chem 56: 1149-1159

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.497 Å
Organisms	Homo sapiens
Macromolecule	Macrophage metalloelastase (protein)
Unique Ligands	CA, R4B, ZN

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4GR3 \| pdb_00004gr3	Download File View File

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470A

Stura, E.A., Vera, L., Beau, F., Devel, L., Cassar-Lajeunesse, E., Dive, V.

(2013) J Med Chem 56: 1149-1159

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.494 Å
Organisms	Homo sapiens
Macromolecule	Macrophage metalloelastase (protein)
Unique Ligands	CA, R45, ZN

Explore in 3D

4GR8 \| pdb_00004gr8	Download File View File

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470C

Stura, E.A., Vera, L., Beau, F., Devel, L., Cassar-Lajeunesse, E., Dive, V.

(2013) J Med Chem 56: 1149-1159

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.299 Å
Organisms	Homo sapiens
Macromolecule	Macrophage metalloelastase (protein)
Unique Ligands	CA, IMD, R4C, ZN

Explore in 3D

4H1Q \| pdb_00004h1q	Download File View File

Crystal structure of mutant MMP-9 catalytic domain in complex with a twin inhibitor.

Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Catalani, M.P., Dive, V., Rossello, A.

(2013) J Struct Biol 182: 246-254

Released	2013-04-24
Method	X-RAY DIFFRACTION 1.59 Å
Organisms	Homo sapiens
Macromolecule	Matrix metalloproteinase-9 (protein)
Unique Ligands	0XX, CA, ZN

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4H2E \| pdb_00004h2e	Download File View File

Crystal structure of an MMP twin inhibitor complexing two MMP-9 catalytic domains

Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Catalani, M.P., Dive, V., Rossello, A.

(2013) J Struct Biol 182: 246-254

Released	2013-04-24
Method	X-RAY DIFFRACTION 2.902 Å
Organisms	Homo sapiens
Macromolecule	Matrix metalloproteinase-9 (protein)
Unique Ligands	0Y3, ACT, BCN, CA, PEG, ZN

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4H30 \| pdb_00004h30	Download File View File

Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.

Antoni, C., Stura, E.A., Vera, L., Nuti, E., Carafa, L., Cassar-Lajeunesse, E., Dive, V., Rossello, A.

(2013) J Struct Biol 182: 246-254

Released	2013-04-24
Method	X-RAY DIFFRACTION 1.43 Å
Organisms	Homo sapiens
Macromolecule	Macrophage metalloelastase (protein)
Unique Ligands	0ZD, CA, GOL, PEG, ZN

Explore in 3D

4H3X \| pdb_00004h3x	Download File View File

Crystal structure of an MMP broad spectrum hydroxamate based inhibitor CC27 in complex with the MMP-9 catalytic domain

Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Dive, V., Rossello, A.

(2013) J Struct Biol 182: 246-254

Released	2013-04-24
Method	X-RAY DIFFRACTION 1.764 Å
Organisms	Homo sapiens
Macromolecule	Matrix metalloproteinase-9 (protein)
Unique Ligands	10B, CA, GOL, PEG, PGO, ZN

Explore in 3D

4H49 \| pdb_00004h49	Download File View File

Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.

Antoni, C., Stura, E.A., Vera, L., Nuti, E., Carafa, L., Cassar-Lajeunesse, E., Dive, V., Rossello, A.

(2013) J Struct Biol 182: 246-254

Released	2013-04-24
Method	X-RAY DIFFRACTION 2.16 Å
Organisms	Homo sapiens
Macromolecule	Macrophage metalloelastase (protein)
Unique Ligands	CA, DMS, GOL, L29, PEG, PGO, ZN

Explore in 3D

4H76 \| pdb_00004h76	Download File View File

Crystal structure of the catalytic domain of Human MMP12 in complex with a broad spectrum hydroxamate inhibitor

Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Dive, V., Rossello, A.

(2013) J Struct Biol 182: 246-254

Released	2013-04-24
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Macrophage metalloelastase (protein)
Unique Ligands	10B, CA, GOL, PEG, PGO, ZN

Explore in 3D

4H82 \| pdb_00004h82	Download File View File

Crystal structure of mutant MMP-9 catalytic domain in complex with a twin inhibitor.

Antoni, C., Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Dive, V., Rossello, A.

(2013) J Struct Biol 182: 246-254

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Matrix metalloproteinase-9 (protein)
Unique Ligands	CA, GOL, L29, PEG, PGO, PPI, ZN

Explore in 3D

4H84 \| pdb_00004h84	Download File View File

Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.

Stura, E.A., Antoni, C., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Dive, V., Rossello, A.

(2013) J Struct Biol 182: 246-254

Released	2013-04-24
Method	X-RAY DIFFRACTION 1.592 Å
Organisms	Homo sapiens
Macromolecule	Macrophage metalloelastase (protein)
Unique Ligands	CA, GOL, PEG, PGO, PGR, Y38, ZN

Explore in 3D

4HMA \| pdb_00004hma	Download File View File

Crystal structure of an MMP twin carboxylate based inhibitor LC20 in complex with the MMP-9 catalytic domain

Stura, E.A., Antoni, C., Vera, L., Nuti, E., Carafa, L., Cassar-Lajeunesse, E., Dive, V., Rossello, A.

(2013) J Struct Biol 182: 246-254

Released	2013-04-24
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Homo sapiens
Macromolecule	Matrix metalloproteinase-9 (protein)
Unique Ligands	0ZD, CA, GOL, MLT, PEG, PGO, ZN

Explore in 3D

4I03 \| pdb_00004i03	Download File View File

Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor

Stura, E.A., Vera, L., Devel, L., Cassar-Lajeunesse, E., Dive, V.

(2013) J Struct Biol 182: 246-254

Released	2013-04-24
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Macrophage metalloelastase (protein)
Unique Ligands	CA, DMS, EDO, GOL, L88, PEG, PGO, ZN

Explore in 3D

4JIJ \| pdb_00004jij	Download File View File

Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate

Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Tranchant, I., Amoura, M., Dive, V.

(2014) Chem Biol 21: 408-413

Released	2014-03-12
Method	X-RAY DIFFRACTION 1.698 Å
Organisms	Homo sapiens
Macromolecule	Matrix metalloproteinase-9 (protein) fluorogenic peptidic substrate (8MC)PLG(PHI)(DNW)AR(NH2) (protein)
Unique Ligands	AZI, CA, EDO, GOL, PEG, PGO, SR, ZN

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4JQG \| pdb_00004jqg	Download File View File

Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate with a fluorine atom.

Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Tranchant, I., Amoura, M., Dive, V.

(2014) Chem Biol 21: 408-413

Released	2014-03-12
Method	X-RAY DIFFRACTION 1.849 Å
Organisms	Homo sapiens
Macromolecule	Matrix metalloproteinase-9 (protein) fluorogenic peptidic substrate (8MC)PLG(PFF)(DNW)AR(NH2) (protein)
Unique Ligands	AZI, CA, EDO, GOL, NA, PGO, SR, ZN

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4WZV \| pdb_00004wzv	Download File View File

Crystal structure of a hydroxamate based inhibitor EN140 in complex with the MMP-9 catalytic domain

Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Dive, V., Rossello, A.

(2015) J Med Chem 58: 7224-7240

Released	2015-08-26
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	Matrix metalloproteinase-9,Matrix metalloproteinase-9 (protein)
Unique Ligands	AZI, CA, E40, EDO, GOL, NA, PEG, PGO, ZN

Explore in 3D

4XCT \| pdb_00004xct	Download File View File

Crystal structure of a hydroxamate based inhibitor ARP101 (EN73) in complex with the MMP-9 catalytic domain.

Stura, E.A., Tepshi, L., Nuti, E., Dive, V., Cassar-Lajeunesse, E., Vera, L., Rossello, A.

(2015) J Med Chem 58: 7224-7240

Released	2015-04-22
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Homo sapiens
Macromolecule	Matrix metalloproteinase-9,Matrix metalloproteinase-9 (protein)
Unique Ligands	BUD, CA, DMS, EDO, GOL, N73, PGO, ZN

1 to 19 of 19 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

3TVC | pdb_00003tvc

Human MMP13 in complex with L-glutamate motif inhibitor

4GQL | pdb_00004gql

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470.1

4GR0 | pdb_00004gr0

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B

4GR3 | pdb_00004gr3

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470A

4GR8 | pdb_00004gr8

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470C

4H1Q | pdb_00004h1q

Crystal structure of mutant MMP-9 catalytic domain in complex with a twin inhibitor.

4H2E | pdb_00004h2e

Crystal structure of an MMP twin inhibitor complexing two MMP-9 catalytic domains

4H30 | pdb_00004h30

Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.

4H3X | pdb_00004h3x

Crystal structure of an MMP broad spectrum hydroxamate based inhibitor CC27 in complex with the MMP-9 catalytic domain

4H49 | pdb_00004h49

Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.

4H76 | pdb_00004h76

Crystal structure of the catalytic domain of Human MMP12 in complex with a broad spectrum hydroxamate inhibitor

4H82 | pdb_00004h82

Crystal structure of mutant MMP-9 catalytic domain in complex with a twin inhibitor.

4H84 | pdb_00004h84

Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.

4HMA | pdb_00004hma

Crystal structure of an MMP twin carboxylate based inhibitor LC20 in complex with the MMP-9 catalytic domain

4I03 | pdb_00004i03

Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor

4JIJ | pdb_00004jij

Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate

4JQG | pdb_00004jqg

Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate with a fluorine atom.

4WZV | pdb_00004wzv

Crystal structure of a hydroxamate based inhibitor EN140 in complex with the MMP-9 catalytic domain

4XCT | pdb_00004xct

Crystal structure of a hydroxamate based inhibitor ARP101 (EN73) in complex with the MMP-9 catalytic domain.

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3TVC | pdb_00003tvc

4GQL | pdb_00004gql

4GR0 | pdb_00004gr0

4GR3 | pdb_00004gr3

4GR8 | pdb_00004gr8

4H1Q | pdb_00004h1q

4H2E | pdb_00004h2e

4H30 | pdb_00004h30

4H3X | pdb_00004h3x

4H49 | pdb_00004h49

4H76 | pdb_00004h76

4H82 | pdb_00004h82

4H84 | pdb_00004h84

4HMA | pdb_00004hma

4I03 | pdb_00004i03

4JIJ | pdb_00004jij

4JQG | pdb_00004jqg

4WZV | pdb_00004wzv

4XCT | pdb_00004xct