RCSB PDB: Search

3QJ5 \| pdb_00003qj5	Download File View File

S-nitrosoglutathione reductase (GSNOR) in complex with N6022

Chun, L., Kim, H., Sun, X.

(2011) ACS Med Chem Lett 2: 402-406

Released	2011-04-06
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Alcohol dehydrogenase class-3 (protein)
Unique Ligands	022, 1PE, K, N2P, NAD, TRS, ZN

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3QRI \| pdb_00003qri	Download File View File

The crystal structure of human abl1 kinase domain in complex with DCC-2036

Chan, W.W., Wise, S.C., Kaufman, M.D., Ahn, Y.M., Ensinger, C.L., Haack, T., Hood, M.M., Jones, J., Lord, J.W., Lu, W.P., Miller, D., Patt, W.C., Smith, B.D., Petillo, P.A., Rutkoski, T.J., Telikepalli, H., Vogeti, L., Yao, T., Chun, L., Clark, R., Evangelista, P., Gavrilescu, L.C., Lazarides, K., Zaleskas, V.M., Stewart, L.J., Van Etten, R.A., Flynn, D.L.

(2011) Cancer Cell 19: 556-568

Released	2011-06-01
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase ABL1 (protein)
Unique Ligands	919, NA

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3QRJ \| pdb_00003qrj	Download File View File

The crystal structure of human abl1 kinase domain T315I mutant in complex with DCC-2036

Chan, W.W., Wise, S.C., Kaufman, M.D., Ahn, Y.M., Ensinger, C.L., Haack, T., Hood, M.M., Jones, J., Lord, J.W., Lu, W.P., Miller, D., Patt, W.C., Smith, B.D., Petillo, P.A., Rutkoski, T.J., Telikepalli, H., Vogeti, L., Yao, T., Chun, L., Clark, R., Evangelista, P., Gavrilescu, L.C., Lazarides, K., Zaleskas, V.M., Stewart, L.J., Van Etten, R.A., Flynn, D.L.

(2011) Cancer Cell 19: 556-568

Released	2011-06-01
Method	X-RAY DIFFRACTION 1.82 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase ABL1 (protein)
Unique Ligands	919

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3QRK \| pdb_00003qrk	Download File View File

The crystal structure of human abl1 kinase domain in complex with DP-987

Chan, W.W., Wise, S.C., Kaufman, M.D., Ahn, Y.M., Ensinger, C.L., Haack, T., Hood, M.M., Jones, J., Lord, J.W., Lu, W.P., Miller, D., Patt, W.C., Smith, B.D., Petillo, P.A., Rutkoski, T.J., Telikepalli, H., Vogeti, L., Yao, T., Chun, L., Clark, R., Evangelista, P., Gavrilescu, L.C., Lazarides, K., Zaleskas, V.M., Stewart, L.J., Van Etten, R.A., Flynn, D.L.

(2011) Cancer Cell 19: 556-568

Released	2011-06-01
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase ABL1 (protein)
Unique Ligands	9DP

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4QFC \| pdb_00004qfc	Download File View File

Co-crystal structure of compound 3 (4-hydroxy-6-[2-(7-hydroxy-2-oxo-4-phenyl-2h-chromen-6-yl)ethyl]pyridazin-3(2h)-one) and FAD bound to human DAAO at 2.4A

Lukacs, C.M., Chun, L.

(2014) Biosci Rep 34:

Released	2014-07-16
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	D-amino-acid oxidase (protein)
Unique Ligands	31T, FAD, K

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4QFD \| pdb_00004qfd	Download File View File

Co-crystal structure of compound 2 (3-(7-hydroxy-2-oxo-4-phenyl-2H-chromen-6-yl)propanoic acid) and FAD bound to human DAAO at 2.85A

Edwards, T.E., Chun, L., Arakaki, T.L.

(2014) Biosci Rep 34:

Released	2014-07-16
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Homo sapiens
Macromolecule	D-amino-acid oxidase (protein)
Unique Ligands	31R, FAD, NA

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5C9C \| pdb_00005c9c	Download File View File

CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND

Edwards, T., Abendroth, J., Chun, L.

(2015) Cancer Cell 28: 384-398

Released	2015-07-15
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	4Z5, CL

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5DG5 \| pdb_00005dg5	Download File View File

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157

Smith, B.D., Kaufman, M.D., Leary, C.B., Turner, B.A., Wise, S.A., Ahn, Y.M., Booth, R.J., Caldwell, T.M., Ensinger, C.L., Hood, M.M., Lu, W.-P., Patt, T.W., Patt, W.C., Rutkoski, T.J., Samarakoon, T., Telikepalli, H., Vogeti, L., Vogeti, S., Yates, K.M., Chun, L., Stewart, L.J., Clare, M., Flynn, D.L.

(2015) Mol Cancer Ther 14: 2023-2034

Released	2016-08-31
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	5B4

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6MOB \| pdb_00006mob	Download File View File

Crystal structure of KIT1 in complex with DP2976 via co-crystallization

Edwards, T.E., Abendroth, J., Safford, K., Chun, L.

(2019) Cancer Cell 35: 738-751.e9

Released	2019-07-31
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Mast/stem cell growth factor receptor Kit (protein)
Unique Ligands	JWY, NO3

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6MWE \| pdb_00006mwe	Download File View File

CRYSTAL STRUCTURE OF TIE2 IN COMPLEX WITH DECIPERA COMPOUND DP1919

Chun, L., Abendroth, J., Edwards, T.E.

(2017) Mol Cancer Ther 16: 2486-2501

Released	2018-11-21
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Angiopoietin-1 receptor (protein)
Unique Ligands	919, SO4

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7TNH \| pdb_00007tnh	Download File View File

Crystal structure of CSF1R kinase domain in complex with DP-6233

Edwards, T.E., Arakaki, T.L., Chun, L., Flynn, D.L.

(2022) Bioorg Med Chem Lett 74: 128929-128929

Released	2022-08-24
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Macrophage colony-stimulating factor 1 receptor,Fibroblast growth factor receptor 1 chimera (protein)
Unique Ligands	CL, I9W, NA

3QJ5 | pdb_00003qj5

S-nitrosoglutathione reductase (GSNOR) in complex with N6022

3QRI | pdb_00003qri

The crystal structure of human abl1 kinase domain in complex with DCC-2036

3QRJ | pdb_00003qrj

The crystal structure of human abl1 kinase domain T315I mutant in complex with DCC-2036

3QRK | pdb_00003qrk

The crystal structure of human abl1 kinase domain in complex with DP-987

4QFC | pdb_00004qfc

Co-crystal structure of compound 3 (4-hydroxy-6-[2-(7-hydroxy-2-oxo-4-phenyl-2h-chromen-6-yl)ethyl]pyridazin-3(2h)-one) and FAD bound to human DAAO at 2.4A

4QFD | pdb_00004qfd

Co-crystal structure of compound 2 (3-(7-hydroxy-2-oxo-4-phenyl-2H-chromen-6-yl)propanoic acid) and FAD bound to human DAAO at 2.85A

5C9C | pdb_00005c9c

CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND

5DG5 | pdb_00005dg5

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157

6MOB | pdb_00006mob

Crystal structure of KIT1 in complex with DP2976 via co-crystallization

6MWE | pdb_00006mwe

CRYSTAL STRUCTURE OF TIE2 IN COMPLEX WITH DECIPERA COMPOUND DP1919

7TNH | pdb_00007tnh

Crystal structure of CSF1R kinase domain in complex with DP-6233

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Enzyme Classification Name

Symmetry Type

SCOP Classification

3QJ5 | pdb_00003qj5

3QRI | pdb_00003qri

3QRJ | pdb_00003qrj

3QRK | pdb_00003qrk

4QFC | pdb_00004qfc

4QFD | pdb_00004qfd

5C9C | pdb_00005c9c

5DG5 | pdb_00005dg5

6MOB | pdb_00006mob

6MWE | pdb_00006mwe

7TNH | pdb_00007tnh