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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Cortes, D.M."

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Search Summary

This query matches 18 Structures.

Refinements

Structure Determination Methodology

experimental (18)

Scientific Name of Source Organism

	Mus musculus (17)
	Streptomyces lividans (16)
	Streptomyces coelicolor A3(2) (2)

Taxonomy

	Bacteria (18)
	Eukaryota (17)

Experimental Method

	X-RAY DIFFRACTION (17)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (18)

Refinement Resolution (Å)

	2.0 - 2.5 (8)
	2.5 - 3.0 (2)
	3.0 - 3.5 (7)

Release Date

	2000 - 2004 (1)
	2005 - 2009 (2)
	2010 - 2014 (9)
	2015 - 2019 (6)

Membrane Protein Annotation

	PDBTM (18)
	MemProtMD (16)
	mpstruc (15)
	OPM (9)

Symmetry Type

	Cyclic (14)
	Asymmetric (11)

SCOP Classification

	All beta proteins (11)
	Artifacts (11)
	Membrane and cell surface proteins and peptides (12)

AllSelected

1 to 18 of 18 Structures

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1F6G \| pdb_00001f6g	Download File View File

POTASSIUM CHANNEL (KCSA) FULL-LENGTH FOLD

Cortes, D.M., Perozo, E.

(2001) J Gen Physiol 117: 165-180

Released	2001-02-21
Method	SOLUTION NMR
Organisms	Streptomyces lividans
Macromolecule	VOLTAGE-GATED POTASSIUM CHANNEL (protein)

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1ZWI \| pdb_00001zwi	Download File View File

Structure of mutant KcsA potassium channel

Cordero-Morales, J.F., Cuello, L.G., Zhao, Y., Jogini, V., Cortes, D.M., Roux, B., Perozo, E.

(2006) Nat Struct Mol Biol 13: 311-318

Released	2006-03-07
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Voltage-gated potassium channel (protein) monoclonal antibody light chain (protein) monoclonal antibody, heavy chain (protein)
Unique Ligands	DGA, F09, K

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2P7T \| pdb_00002p7t	Download File View File

Crystal Structure of KcsA mutant

Cordero-Morales, J.F., Vishwanath, J., Lewis, A., Valeria, V.R., Cortes, D.M., Roux, B., Perozo, E.

To be published

Released	2007-10-09
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	FAB-A (protein) FAB-B (protein) Voltage-gated potassium channel (protein)
Unique Ligands	1EM, F09, K

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3F5W \| pdb_00003f5w	Download File View File

KcsA Potassium channel in the open-inactivated state with 32 A opening at T112

Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E.

To be published

Released	2010-05-19
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Antibody heavy chain (protein) Antibody light chain (protein) Voltage-gated potassium channel (protein)
Unique Ligands	K

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3F7V \| pdb_00003f7v	Download File View File

KcsA Potassium channel in the open-inactivated state with 23 A opening at T112

Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E.

To be published

Released	2010-05-19
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Voltage-gated potassium channel (protein) antibody fab fragment Heavy chain (protein) antibody fab fragment light chain (protein)
Unique Ligands	K

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3F7Y \| pdb_00003f7y	Download File View File

KcsA Potassium channel in the partially open state with 17 A opening at T112

Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E.

To be published

Released	2010-05-19
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Voltage-gated potassium channel (protein) antibody fab fragment heavy chain (protein) antibody fab fragment light chain (protein)
Unique Ligands	K

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3FB5 \| pdb_00003fb5	Download File View File

KcsA potassium channel in the partially open state with 14.5 A opening at T112

Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E.

To be published

Released	2010-05-19
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Voltage-gated potassium channel (protein) antibody Fab fragment heavy chain (protein) antibody Fab fragment light chain (protein)
Unique Ligands	K

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3FB6 \| pdb_00003fb6	Download File View File

KcsA Potassium channel in the partially open state with 16 A opening at T112

Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E.

To be published

Released	2010-05-19
Method	X-RAY DIFFRACTION 3 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Voltage-gated potassium channel (protein) antibody fab fragment heavy chain (protein) antibody fab fragment light chain (protein)
Unique Ligands	K

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3FB7 \| pdb_00003fb7	Download File View File

Open KcsA potassium channel in the presence of Rb+ ion

Cuello, L.G., Jogini, V., Cortes, D.M., Pan, A.C., Gagnon, D.H., Cordero-Morales, J.F., Chakrapani, S., Roux, B., Perozo, E.

To be published

Released	2010-07-14
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Voltage-gated potassium channel (protein) antibody fab fragment heavy chain (protein) antibody fab fragment light chain (protein)
Unique Ligands	RB

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3FB8 \| pdb_00003fb8	Download File View File

KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion

Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E.

To be published

Released	2010-05-19
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Voltage-gated potassium channel (protein) antibody fab fragment heavy chain (protein) antibody fab fragment light chain (protein)
Unique Ligands	RB

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3HPL \| pdb_00003hpl	Download File View File

KcsA E71H-F103A mutant in the closed state

Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E.

(2010) Nature 466: 272-275

Released	2010-06-23
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Antibody Fab heavy chain (protein) Antibody fab light chain (protein) Voltage-gated potassium channel (protein)
Unique Ligands	K

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3OR7 \| pdb_00003or7	Download File View File

On the structural basis of modal gating behavior in K+channels - E71I

Chakrapani, S., Cordero-Morales, J.F., Jogini, V., Pan, A.C., Cortes, D.M., Roux, B., Perozo, E.

(2011) Nat Struct Mol Biol 18: 67-74

Released	2011-01-05
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Voltage-gated potassium channel (protein) antibody fab fragment heavy chain (protein) antibody fab fragment light chain (protein)
Unique Ligands	K

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5VKE \| pdb_00005vke	Download File View File

Open conformation of KcsA deep-inactivated

Cuello, L.G., Perozo, E., Cortes, D.M.

(2017) Elife 6:

Released	2017-12-06
Method	X-RAY DIFFRACTION 2.37 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Antibody Heavy Chain (protein) Antibody Light Chain (protein) pH-gated potassium channel KcsA (protein)
Unique Ligands	1EM, F09, K

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5VKH \| pdb_00005vkh	Download File View File

Closed conformation of KcsA Y82A-F103A mutant

Cuello, L.G., Perozo, E., Cortes, D.M.

(2017) Elife 6:

Released	2017-12-06
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	Antibody Heavy Chain (protein) Antibody Light Chain (protein) pH-gated potassium channel KcsA (protein)
Unique Ligands	1EM, F09, K

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6BY2 \| pdb_00006by2	Download File View File

Closed and deep-inactivated conformation of KcsA-T75A mutant

Labro, A.J., Cortes, D.M., Tilegenova, C., Cuello, L.G.

(2018) Proc Natl Acad Sci U S A 115: 5426-5431

Released	2018-05-09
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Mus musculus Streptomyces coelicolor A3(2)
Macromolecule	Antibody Heavy Chain (protein) Antibody Light Chain (protein) pH-gated potassium channel KcsA (protein)
Unique Ligands	DGA, F09, K

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6BY3 \| pdb_00006by3	Download File View File

Open and conductive conformation of KcsA-T75A mutant

Labro, A.J., Cortes, D.M., Tilegenova, C., Cuello, L.G.

(2018) Proc Natl Acad Sci U S A 115: 5426-5431

Released	2018-05-09
Method	X-RAY DIFFRACTION 2.37 Å
Organisms	Mus musculus Streptomyces coelicolor A3(2)
Macromolecule	Antibody Heavy Chain (protein) Antibody Light Chain (protein) pH-gated potassium channel KcsA (protein)
Unique Ligands	DGA, F09, K

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6NFU \| pdb_00006nfu	Download File View File

Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.

Tilegenova, C., Cortes, D.M., Jahovic, N., Hardy, E., Parameswaran, H., Guan, L., Cuello, L.G.

(2019) Proc Natl Acad Sci U S A 116: 16829-16834

Released	2019-08-07
Method	X-RAY DIFFRACTION 2.09 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	antibody fragment heavy chain (protein) antibody fragment light chain (protein) pH-gated potassium channel KcsA (protein)
Unique Ligands	1EM, F09, K

Explore in 3D

6NFV \| pdb_00006nfv	Download File View File

Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.

Tilegenova, C., Cortes, D.M., Jahovic, N., Hardy, E., Parameswaran, H., Guan, L., Cuello, L.G.

(2019) Proc Natl Acad Sci U S A 116: 16829-16834

Released	2019-08-07
Method	X-RAY DIFFRACTION 2.13 Å
Organisms	Mus musculus Streptomyces lividans
Macromolecule	antibody fragment heavy chain (protein) antibody fragment light chain (protein) pH-gated potassium channel KcsA (protein)
Unique Ligands	1EM, F09, K

1 to 18 of 18 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1F6G | pdb_00001f6g

POTASSIUM CHANNEL (KCSA) FULL-LENGTH FOLD

1ZWI | pdb_00001zwi

Structure of mutant KcsA potassium channel

2P7T | pdb_00002p7t

Crystal Structure of KcsA mutant

3F5W | pdb_00003f5w

KcsA Potassium channel in the open-inactivated state with 32 A opening at T112

3F7V | pdb_00003f7v

KcsA Potassium channel in the open-inactivated state with 23 A opening at T112

3F7Y | pdb_00003f7y

KcsA Potassium channel in the partially open state with 17 A opening at T112

3FB5 | pdb_00003fb5

KcsA potassium channel in the partially open state with 14.5 A opening at T112

3FB6 | pdb_00003fb6

KcsA Potassium channel in the partially open state with 16 A opening at T112

3FB7 | pdb_00003fb7

Open KcsA potassium channel in the presence of Rb+ ion

3FB8 | pdb_00003fb8

KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion

3HPL | pdb_00003hpl

KcsA E71H-F103A mutant in the closed state

3OR7 | pdb_00003or7

On the structural basis of modal gating behavior in K+channels - E71I

5VKE | pdb_00005vke

Open conformation of KcsA deep-inactivated

5VKH | pdb_00005vkh

Closed conformation of KcsA Y82A-F103A mutant

6BY2 | pdb_00006by2

Closed and deep-inactivated conformation of KcsA-T75A mutant

6BY3 | pdb_00006by3

Open and conductive conformation of KcsA-T75A mutant

6NFU | pdb_00006nfu

Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.

6NFV | pdb_00006nfv

Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1F6G | pdb_00001f6g

1ZWI | pdb_00001zwi

2P7T | pdb_00002p7t

3F5W | pdb_00003f5w

3F7V | pdb_00003f7v

3F7Y | pdb_00003f7y

3FB5 | pdb_00003fb5

3FB6 | pdb_00003fb6

3FB7 | pdb_00003fb7

3FB8 | pdb_00003fb8

3HPL | pdb_00003hpl

3OR7 | pdb_00003or7

5VKE | pdb_00005vke

5VKH | pdb_00005vkh

6BY2 | pdb_00006by2

6BY3 | pdb_00006by3

6NFU | pdb_00006nfu

6NFV | pdb_00006nfv