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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Das, S."

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Search Summary

This query matches 88 Structures.

Refinements

Structure Determination Methodology

experimental (88)

Scientific Name of Source Organism

	Homo sapiens (85)
	Mus musculus (3)
	Rattus norvegicus (3)
	Human betacoronavirus 2c EMC/2012 (1)
	Macaca mulatta (1)
	Manis javanica (1)
	Middle East respiratory syndrome-related coronavirus (1)
	Pangolin coronavirus HKU4 (1)
	Tylonycteris bat coronavirus HKU4 (1)

Taxonomy

	Eukaryota (88)
	Riboviria (4)
	Eukaryota (eukaryotes) (1)

Experimental Method

X-RAY DIFFRACTION (88)

Polymer Entity Type

Protein (88)

Refinement Resolution (Å)

	1.5 - 2.0 (8)
	2.0 - 2.5 (45)
	2.5 - 3.0 (24)
	3.0 - 3.5 (9)
	3.5 - 4.0 (2)

Release Date

	2000 - 2004 (4)
	2005 - 2009 (33)
	2010 - 2014 (32)
	2015 - 2019 (17)
	2020 - 2024 (2)

Enzyme Classification Name

Hydrolases (88)

Symmetry Type

	Cyclic (86)
	Asymmetric (15)

SCOP Classification

	All beta proteins (81)
	Alpha and beta proteins (a/b) (81)
	Artifacts (21)

AllSelected

1 to 25 of 88 Structures

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1R9M \| pdb_00001r9m	Download File View File

Crystal Structure of Human Dipeptidyl Peptidase IV at 2.1 Ang. Resolution.

Aertgeerts, K., Ye, S., Tennant, M.G., Collins, B., Rogers, J., Sang, B.C., Skene, R.J., Webb, D.R., Prasad, G.S.

(2004) Protein Sci 13: 412-421

Released	2004-06-29
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase IV (protein)
Unique Ligands	FUC, NAG
Unique branched monosaccharides	MAN, NAG

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1R9N \| pdb_00001r9n	Download File View File

Crystal Structure of human dipeptidyl peptidase IV in complex with a decapeptide (tNPY) at 2.3 Ang. Resolution

Aertgeerts, K., Ye, S., Tennant, M.G., Collins, B., Rogers, J., Sang, B.-C., Skene, R., Webb, D.R., Prasad, G.S.

(2004) Protein Sci 13: 412-421

Released	2005-03-29
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens Macaca mulatta
Macromolecule	Dipeptidyl peptidase IV (protein) Neuropeptide Y (protein)
Unique Ligands	NAG
Unique branched monosaccharides	NAG

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1TK3 \| pdb_00001tk3	Download File View File

Crystal Structure Of Human Apo Dipeptidyl Peptidase IV/CD26

Bjelke, J.R., Christensen, J., Branner, S., Wagtmann, N., Olsen, C., Kanstrup, A.B., Rasmussen, H.B.

(2004) J Biological Chem 279: 34691-34697

Released	2004-07-06
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase IV (protein)
Unique Ligands	NAG
Unique branched monosaccharides	BMA, FUC, MAN, NAG, NDG

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1TKR \| pdb_00001tkr	Download File View File

Human Dipeptidyl Peptidase IV/CD26 inhibited with Diisopropyl FluoroPhosphate

Bjelke, J.R., Christensen, J., Branner, S., Wagtmann, N., Olsen, C., Kanstrup, A.B., Rasmussen, H.B.

(2004) J Biological Chem 279: 34691-34697

Released	2004-07-06
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase IV (protein)
Unique Ligands	DFP, NAG
Unique branched monosaccharides	BMA, FUC, MAN, NAG, NDG

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1U8E \| pdb_00001u8e	Download File View File

HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 MUTANT Y547F

Bjelke, J.R., Christensen, J., Branner, S., Wagtmann, N., Olsen, C., Kanstrup, A.B., Rasmussen, H.B.

(2004) J Biological Chem 279: 34691-34697

Released	2004-08-17
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase IV (protein)
Unique Ligands	NAG
Unique branched monosaccharides	BMA, FUC, MAN, NAG, NDG

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1X70 \| pdb_00001x70	Download File View File

HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR

Kim, D., Wang, L., Beconi, M., Eiermann, G.J., Fisher, M.H., He, H., Hickey, G.J., Leiting, B., Lyons, K.

(2005) J Med Chem 48: 141-151

Released	2005-01-18
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase IV (protein)
Unique Ligands	715, NA, NAG
Unique branched monosaccharides	NAG, NDG

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2AJL \| pdb_00002ajl	Download File View File

X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor

Qiao, L., Baumann, C.A., Crysler, C.S., Ninan, N.S., Abad, M.C., Spurlino, J.C., DesJarlais, R.L., Kervinen, J., Neeper, M.P., Bayoumy, S.S.

(2006) Bioorg Med Chem Lett 16: 123-128

Released	2005-11-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	JNH, NAG

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2FJP \| pdb_00002fjp	Download File View File

Human dipeptidyl peptidase IV/CD26 in complex with an inhibitor

Scapin, G., Patel, S.B., Becker, J.W.

(2006) J Med Chem 49: 3614-3627

Released	2006-07-04
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	NAG, S14
Unique branched monosaccharides	NAG

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2G5P \| pdb_00002g5p	Download File View File

Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 21ac

Longenecker, K.L., Fry, E.H., Lake, M.R., Solomon, L.R., Pei, Z., Li, X.

(2006) J Med Chem 49: 3520-3535

Released	2006-07-04
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	ADF

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2G5T \| pdb_00002g5t	Download File View File

Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 21ag

Longenecker, K.L., Fry, E.H., Lake, M.R., Solomon, L.R., Pei, Z., Li, X.

(2006) J Med Chem 49: 3520-3535

Released	2006-07-04
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	ACF

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2G63 \| pdb_00002g63	Download File View File

Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 24b

Longenecker, K.L., Fry, E.H., Lake, M.R., Solomon, L.R., Pei, Z., Li, X.

(2006) J Med Chem 49: 3520-3535

Released	2006-07-04
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	AAF

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2HHA \| pdb_00002hha	Download File View File

The structure of DPP4 in complex with an oxadiazole inhibitor

Scapin, G.

(2006) Bioorg Med Chem Lett 16: 5373-5377

Released	2006-09-19
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Hypothetical protein DPP4 (protein)
Unique Ligands	3TP, NA, NAG
Unique branched monosaccharides	NAG, NDG

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2I03 \| pdb_00002i03	Download File View File

Crystal structure of human dipeptidyl peptidase 4 (DPP IV) with potent alkynyl cyanopyrrolidine (ABT-279)

Longenecker, K.L., Madar, D.J.

(2006) J Med Chem 49: 6416-6420

Released	2006-12-12
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	AXD

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2I78 \| pdb_00002i78	Download File View File

Crystal structure of human dipeptidyl peptidase IV (DPP IV) complexed with ABT-341, a cyclohexene-constrained phenethylamine inhibitor

Longenecker, K.L., Pei, Z., Li, X.

To be published

Released	2007-10-09
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase IV (protein)
Unique Ligands	KIQ

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2IIT \| pdb_00002iit	Download File View File

Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor

Scapin, G., Biftu, T., Weber, A.E.

(2007) Bioorg Med Chem Lett 17: 49-52

Released	2006-11-28
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 soluble form (protein)
Unique Ligands	872, NA, NAG
Unique branched monosaccharides	NAG, NDG

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2IIV \| pdb_00002iiv	Download File View File

Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor

Scapin, G., Weber, A.E., Biftu, T.

(2007) Bioorg Med Chem Lett 17: 49-52

Released	2006-11-28
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 soluble form (protein)
Unique Ligands	565, NAG
Unique branched monosaccharides	NAG

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2OAG \| pdb_00002oag	Download File View File

Crystal structure of human dipeptidyl peptidase IV (DPPIV) with pyrrolidine-constrained phenethylamine 29g

Backes, B.J., Longenecker, K.L., Hamilton, G.L., Stewart, K.D., Lai, C., Kopecka, H.

(2007) Bioorg Med Chem Lett 17: 2005-2012

Released	2007-09-11
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	DLI

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2OGZ \| pdb_00002ogz	Download File View File

Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor

Timm, D.E.

(2007) Bioorg Med Chem Lett 17: 1765-1768

Released	2007-03-06
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase (protein)
Unique Ligands	U1N

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2ONC \| pdb_00002onc	Download File View File

Crystal structure of human DPP-4

Feng, J., Zhang, Z., Wallace, M.B., Stafford, J.A., Kaldor, S.W., Kassel, D.B., Navre, M., Shi, L., Skene, R.J., Asakawa, T., Takeuchi, K., Xu, R., Webb, D.R., Gwaltney, S.L.

(2007) J Med Chem 50: 2297-2300

Released	2008-03-04
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	NAG, SY1
Unique branched monosaccharides	NAG

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2OPH \| pdb_00002oph	Download File View File

Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor

Scapin, G., Weber, A.E., Duffy, J.L.

(2007) Bioorg Med Chem Lett 17: 2879-2885

Released	2007-05-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 soluble form (protein)
Unique Ligands	277, NA, NAG
Unique branched monosaccharides	NAG, NDG

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2OQI \| pdb_00002oqi	Download File View File

Human Dipeptidyl Peptidase IV (DPP4) with Piperidinone-constrained phenethylamine

Pei, Z., Li, X., von Geldern, T.W., Longenecker, K.L., Pireh, D., Stewart, K.D., Backes, B.J., Lai, C., Lubben, T.H., Ballaron, S.J., Beno, D.W., Kempf-Grote, A.J., Sham, H.L., Trevillyan, J.M.

(2007) J Med Chem 50: 1983-1987

Released	2007-04-03
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (Adenosine deaminase complexing protein 2) (ADABP) (protein)
Unique Ligands	GGO

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2OQV \| pdb_00002oqv	Download File View File

Human Dipeptidyl Peptidase IV (DPP4) with piperidine-constrained phenethylamine

Pei, Z., Li, X., von Geldern, T.W., Longenecker, K.L., Pireh, D., Stewart, K.D.

(2007) J Med Chem 50: 1983-1987

Released	2007-04-24
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (Dipeptidyl peptidase IV) (DPP IV) (protein)
Unique Ligands	MA9

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2P8S \| pdb_00002p8s	Download File View File

Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor

Scapin, G., Biftu, T.

(2007) Bioorg Med Chem Lett 17: 3384-3387

Released	2007-05-22
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	DIPEPTIDYL PEPTIDASE IV SOLUBLE FORM (protein)
Unique Ligands	417, NA, NAG
Unique branched monosaccharides	NAG

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2QJR \| pdb_00002qjr	Download File View File

dipepdyl peptidase IV in complex with inhibitor PZF

Shenping, L.

(2007) Bioorg Med Chem Lett 17: 5638-5642

Released	2008-07-29
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 membrane form (protein)
Unique Ligands	LGU, NAG, PZF
Unique branched monosaccharides	LGU, MAN, NAG

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2QKY \| pdb_00002qky	Download File View File

complex structure of dipeptidyl peptidase IV and a oxadiazolyl ketone

Kim, K.-H., Hong, S.Y., Koo, K.D., Lee, C.-S., Kim, G.T., Han, H.O.

(2007) Bioorg Med Chem Lett 17: 4167-4172

Released	2008-07-15
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (Adenosine deaminase complexing protein 2) (ADABP) (Dipeptidyl peptidase 4 soluble form) (Dipeptidyl peptidase IV soluble form) (protein)
Unique Ligands	13Z

1 to 25 of 88 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1R9M | pdb_00001r9m

1R9N | pdb_00001r9n

1TK3 | pdb_00001tk3

1TKR | pdb_00001tkr

1U8E | pdb_00001u8e

1X70 | pdb_00001x70

2AJL | pdb_00002ajl

2FJP | pdb_00002fjp

2G5P | pdb_00002g5p

2G5T | pdb_00002g5t

2G63 | pdb_00002g63

2HHA | pdb_00002hha

2I03 | pdb_00002i03

2I78 | pdb_00002i78

2IIT | pdb_00002iit

2IIV | pdb_00002iiv

2OAG | pdb_00002oag

2OGZ | pdb_00002ogz

2ONC | pdb_00002onc

2OPH | pdb_00002oph

2OQI | pdb_00002oqi

2OQV | pdb_00002oqv

2P8S | pdb_00002p8s

2QJR | pdb_00002qjr

2QKY | pdb_00002qky