RCSB PDB: Search

1DF7 \| pdb_00001df7	Download File View File

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE

Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.

(2000) J Mol Biology 295: 307-323

Released	2000-03-09
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	DIHYDROFOLATE REDUCTASE (protein)
Unique Ligands	GOL, MTX, NDP, SO4

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1DG5 \| pdb_00001dg5	Download File View File

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND TRIMETHOPRIM

Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.

(2000) J Mol Biology 295: 307-323

Released	2000-03-09
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	DIHYDROFOLATE REDUCTASE (protein)
Unique Ligands	GOL, NDP, TOP

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1DG7 \| pdb_00001dg7	Download File View File

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210

Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.

(2000) J Mol Biology 295: 307-323

Released	2000-03-09
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	DIHYDROFOLATE REDUCTASE (protein)
Unique Ligands	GOL, NDP, WRB

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1DG8 \| pdb_00001dg8	Download File View File

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH

Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.

(2000) J Mol Biology 295: 307-323

Released	2000-03-09
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	DIHYDROFOLATE REDUCTASE (protein)
Unique Ligands	GOL, NDP

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1J3I \| pdb_00001j3i	Download File View File

Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP

Yuvaniyama, J., Chitnumsub, P., Kamchonwongpaisan, S., Vanichtanankul, J., Sirawaraporn, W., Taylor, P., Walkinshaw, M., Yuthavong, Y.

(2003) Nat Struct Biol 10: 357-365

Released	2003-05-06
Method	X-RAY DIFFRACTION 2.33 Å
Organisms	Plasmodium falciparum
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	NDP, UMP, WRA

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1J3J \| pdb_00001j3j	Download File View File

Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP

Yuvaniyama, J., Chitnumsub, P., Kamchonwongpaisan, S., Vanichtanankul, J., Sirawaraporn, W., Taylor, P., Walkinshaw, M., Yuthavong, Y.

(2003) Nat Struct Biol 10: 357-365

Released	2003-05-06
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Plasmodium falciparum
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	CP6, NDP, UMP

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1J3K \| pdb_00001j3k	Download File View File

Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP

Yuvaniyama, J., Chitnumsub, P., Kamchonwongpaisan, S., Vanichtanankul, J., Sirawaraporn, W., Taylor, P., Walkinshaw, M., Yuthavong, Y.

(2003) Nat Struct Biol 10: 357-365

Released	2003-05-06
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Plasmodium falciparum
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	NDP, UMP, WRA

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2BL9 \| pdb_00002bl9	Download File View File

X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative

Kongsaeree, P., Khongsuk, P., Leartsakulpanich, U., Chitnumsub, P., Tarnchompoo, B., Walkinshaw, M.D., Yuthavong, Y.

(2005) Proc Natl Acad Sci U S A 102: 13046

Released	2005-09-07
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Plasmodium vivax
Macromolecule	DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (protein)
Unique Ligands	CP6, NDP

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2BLA \| pdb_00002bla	Download File View File

SP21 double mutant P. vivax Dihydrofolate reductase in complex with pyrimethamine

Kongsaeree, P., Khongsuk, P., Leartsakulpanich, U., Chitnumsub, P., Tarnchompoo, B., Walkinshaw, M.D., Yuthavong, Y.

(2005) Proc Natl Acad Sci U S A 102: 13046

Released	2005-09-07
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Plasmodium vivax
Macromolecule	DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (protein)
Unique Ligands	CP6, MES, NDP

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2BLB \| pdb_00002blb	Download File View File

X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative

Kongsaeree, P., Khongsuk, P., Leartsakulpanich, U., Chitnumsub, P., Tarnchompoo, B., Walkinshaw, M.D., Yuthavong, Y.

(2005) Proc Natl Acad Sci U S A 102: 13046

Released	2005-09-07
Method	X-RAY DIFFRACTION 3 Å
Organisms	Plasmodium vivax
Macromolecule	DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (protein)
Unique Ligands	CP7, MES, NDP

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2BLC \| pdb_00002blc	Download File View File

SP21 double mutant P. vivax Dihydrofolate reductase in complex with des-chloropyrimethamine

Kongsaeree, P., Khongsuk, P., Leartsakulpanich, U., Chitnumsub, P., Tarnchompoo, B., Walkinshaw, M.D., Yuthavong, Y.

(2005) Proc Natl Acad Sci U S A 102: 13046

Released	2005-09-07
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Plasmodium vivax
Macromolecule	DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (protein)
Unique Ligands	CP7, MES, NDP

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3DG8 \| pdb_00003dg8	Download File View File

Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP

Dasgupta, T., Chitnumsub, P., Maneeruttanarungroj, C., Kamchonwongpaisan, S., Nichols, S., Lyons, T.M., Tirado-Rives, J., Jorgensen, W.L., Yuthavong, Y., Anderson, K.S.

(2009) ACS Chem Biol 4: 29-40

Released	2009-01-27
Method	X-RAY DIFFRACTION 2.58 Å
Organisms	Plasmodium falciparum
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	NDP, RJ6, UMP

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3DGA \| pdb_00003dga	Download File View File

Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP

Dasgupta, T., Chitnumsub, P., Maneeruttanarungroj, C., Kamchonwongpaisan, S., Nichols, S., Lyons, T.M., Tirado-Rives, J., Jorgensen, W.L., Yuthavong, Y., Anderson, K.S.

(2009) ACS Chem Biol 4: 29-40

Released	2009-01-27
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Plasmodium falciparum
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	NDP, RJ1, UMP

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3INV \| pdb_00003inv	Download File View File

Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH, dUMP AND C-448 ANTIFOLATE

Chitnumsub, P., Yuvaniyama, J., Yuthavong, Y.

To be published

Released	2010-07-28
Method	X-RAY DIFFRACTION 2.37 Å
Organisms	Trypanosoma cruzi
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	C50, GOL, NDP, UMP

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3IRM \| pdb_00003irm	Download File View File

Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil

Chitnumsub, P., Yuvaniyama, J., Yuthavong, Y.

To be published

Released	2010-07-28
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Trypanosoma cruzi
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	1CY, ACT, PO4

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3IRN \| pdb_00003irn	Download File View File

Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil

Chitnumsub, P., Yuvaniyama, J., Yuthavong, Y.

To be published

Released	2010-07-28
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Trypanosoma cruzi
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	1CY, NDP, PO4

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3IRO \| pdb_00003iro	Download File View File

Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase complexed with NADPH and Q-8 antifolate

Chitnumsub, P., Yuvaniyama, J., Yuthavong, Y.

To be published

Released	2010-07-28
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Trypanosoma cruzi
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	2CY, ACT, GOL, NDP, PO4

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3JSU \| pdb_00003jsu	Download File View File

Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP

Chitnumsub, P., Maneeruttanarungroj, C., Kamchonwongpaisan, S., Yuthavong, Y., Diagana, T.T.

(2010) Antimicrob Agents Chemother 54: 2603-2610

Released	2010-07-28
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Plasmodium falciparum
Macromolecule	Dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	KA5, NDP, UMP

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3QFX \| pdb_00003qfx	Download File View File

Trypanosoma brucei dihydrofolate reductase pyrimethamine complex

Vanichtanankul, J., Yuvaniyama, J., Taweechai, S., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.

(2011) ACS Chem Biol 6: 905-911

Released	2011-06-29
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Trypanosoma brucei rhodesiense
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	CP6, NDP

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3QG2 \| pdb_00003qg2	Download File View File

Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex

Vanichtanankul, J., Yuvaniyama, J., Taweechai, S., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.

(2011) ACS Chem Biol 6: 905-911

Released	2011-06-29
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Plasmodium falciparum
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	CP6, NDP, UMP

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3QGT \| pdb_00003qgt	Download File View File

Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE

Chitnumsub, P., Yuthavong, Y.

(2011) ACS Chem Biol 6: 905-911

Released	2011-06-29
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Plasmodium falciparum
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	CP6, NDP, UMP

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3UM5 \| pdb_00003um5	Download File View File

Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP

Vanichtanankul, J., Kamchonwongpaisan, S., Chitnumsub, P., Yuthavong, Y.

(2012) Antimicrob Agents Chemother 56: 3928-3935

Released	2012-07-18
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Plasmodium falciparum
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	CP6, NDP, UMP

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3UM6 \| pdb_00003um6	Download File View File

Double mutant (A16V+S108T) Plasmodium falciparum DHFR-TS (T9/94) complexed with cycloguanil, NADPH and dUMP

Vanichtanankul, J., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.

(2012) Antimicrob Agents Chemother 56: 3928-3935

Released	2012-07-18
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Plasmodium falciparum
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	1CY, NDP, UMP

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3UM8 \| pdb_00003um8	Download File View File

Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH

Vanichtanankul, J., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.

(2012) Antimicrob Agents Chemother 56: 3928-3935

Released	2012-07-18
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Plasmodium falciparum
Macromolecule	Bifunctional dihydrofolate reductase-thymidylate synthase (protein)
Unique Ligands	1CY, NDP, PO4

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4DDR \| pdb_00004ddr	Download File View File

Human dihydrofolate reductase complexed with NADPH and P218

Yuthavong, Y., Tarnchompoo, B., Vilaivan, T., Chitnumsub, P., Kamchonwongpaisan, S., Charman, S.A., McLennan, D.N., White, K.L., Vivas, L., Bongard, E., Thongphanchang, C., Taweechai, S., Vanichtanankul, J., Rattanajak, R., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W.N., Matthews, D.

(2012) Proc Natl Acad Sci U S A 109: 16823-16828

Released	2012-11-14
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Dihydrofolate reductase (protein)
Unique Ligands	MMV, NDP

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1DF7 | pdb_00001df7

1DG5 | pdb_00001dg5

1DG7 | pdb_00001dg7

1DG8 | pdb_00001dg8

1J3I | pdb_00001j3i

1J3J | pdb_00001j3j

1J3K | pdb_00001j3k

2BL9 | pdb_00002bl9

2BLA | pdb_00002bla

2BLB | pdb_00002blb

2BLC | pdb_00002blc

3DG8 | pdb_00003dg8

3DGA | pdb_00003dga

3INV | pdb_00003inv

3IRM | pdb_00003irm

3IRN | pdb_00003irn

3IRO | pdb_00003iro

3JSU | pdb_00003jsu

3QFX | pdb_00003qfx

3QG2 | pdb_00003qg2

3QGT | pdb_00003qgt

3UM5 | pdb_00003um5

3UM6 | pdb_00003um6

3UM8 | pdb_00003um8

4DDR | pdb_00004ddr