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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Garavito, R.M."

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Search Summary

This query matches 45 Structures.

Refinements

Structure Determination Methodology

experimental (45)

Scientific Name of Source Organism

	Ovis aries (14)
	Arabidopsis thaliana (9)
	Cereibacter sphaeroides (5)
	Amycolatopsis orientalis (4)
	Bacillus subtilis (3)
	Escherichia coli (2)
	Homo sapiens (2)
	Aneurinibacillus thermoaerophilus (1)
	Geobacter metallireducens (1)
	Geobacter sulfurreducens (1)

More...

Taxonomy

	Eukaryota (28)
	Bacteria (18)

Experimental Method

X-RAY DIFFRACTION (45)

Polymer Entity Type

Protein (45)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (9)
	2.0 - 2.5 (13)
	2.5 - 3.0 (12)
	3.0 - 3.5 (6)
	3.5 - 4.0 (2)
	> 4.5 (2)

Release Date

	1995 - 1999 (10)
	2000 - 2004 (15)
	2005 - 2009 (5)
	2010 - 2014 (11)
	2015 - 2019 (4)

Enzyme Classification Name

	Oxidoreductases (20)
	Transferases (9)
	Hydrolases (4)
	Lyases (3)
	Translocases (1)

Membrane Protein Annotation

	mpstruc (6)
	MemProtMD (5)
	PDBTM (5)
	OPM (3)

Symmetry Type

	Cyclic (27)
	Dihedral (14)
	Asymmetric (9)

SCOP Classification

	Alpha and beta proteins (a/b) (21)
	All alpha proteins (17)
	Small proteins (14)
	Alpha and beta proteins (a+b) (3)
	Artifacts (5)
	Membrane and cell surface proteins and peptides (1)
	Multi-domain proteins (alpha and beta) (1)
	All beta proteins (1)
	Designed proteins (1)

AllSelected

1 to 25 of 45 Structures

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1BDG \| pdb_00001bdg	Download File View File

HEXOKINASE FROM SCHISTOSOMA MANSONI COMPLEXED WITH GLUCOSE

Mulichak, A.M., Garavito, R.M.

(1998) Nat Struct Biol 5: 555-560

Released	1999-05-11
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Schistosoma mansoni
Macromolecule	HEXOKINASE (protein)
Unique Ligands	GLC, SO4

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1BG3 \| pdb_00001bg3	Download File View File

RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE

Mulichak, A.M., Garavito, R.M.

(1998) Nat Struct Biol 5: 555-560

Released	1999-06-08
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Rattus norvegicus
Macromolecule	HEXOKINASE (protein)
Unique Ligands	BGC, CA, G6P

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1CQE \| pdb_00001cqe	Download File View File

PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN

Picot, D., Loll, P.J., Mulichak, A.M., Garavito, R.M.

(1994) Nature 367: 243-249

Released	1999-06-30
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Ovis aries
Macromolecule	PROTEIN (PROSTAGLANDIN H2 SYNTHASE-1) (protein)
Unique Ligands	BOG, FLP, HEM
Unique branched monosaccharides	NAG

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1DIY \| pdb_00001diy	Download File View File

CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1

Malkowski, M.G., Ginell, S.L., Smith, W.L., Garavito, R.M.

(2000) Science 289: 1933-1937

Released	2000-09-22
Method	X-RAY DIFFRACTION 3 Å
Organisms	Ovis aries
Macromolecule	PROSTAGLANDIN H2 SYNTHASE-1 (protein)
Unique Ligands	ACD, BOG, COH
Unique branched monosaccharides	BMA, MAN, NAG, NDG

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1FE2 \| pdb_00001fe2	Download File View File

CRYSTAL STRUCTURE OF DIHOMO-GAMMA-LINOLEIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.

Thuresson, E.D., Malkowski, M.G., Lakkides, K.M., Smith, W.L., Garavito, R.M.

(2001) J Biological Chem 276: 10358-10365

Released	2001-05-02
Method	X-RAY DIFFRACTION 3 Å
Organisms	Ovis aries
Macromolecule	PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1 (protein)
Unique Ligands	BOG, COH, LAX
Unique branched monosaccharides	BMA, NAG

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1I24 \| pdb_00001i24	Download File View File

HIGH RESOLUTION CRYSTAL STRUCTURE OF THE WILD-TYPE PROTEIN SQD1, WITH NAD AND UDP-GLUCOSE

Theisen, M.J., Sanda, S.L., Ginell, S.L., Benning, C., Garavito, R.M.

To be published

Released	2003-07-01
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Arabidopsis thaliana
Macromolecule	SULFOLIPID BIOSYNTHESIS PROTEIN SQD1 (protein)
Unique Ligands	NAD, SO4, UPG

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1I2B \| pdb_00001i2b	Download File View File

CRYSTAL STRUCTURE OF MUTANT T145A SQD1 PROTEIN COMPLEX WITH NAD AND UDP-SULFOQUINOVOSE/UDP-GLUCOSE

Theisen, M.J., Sanda, S.L., Ginell, S.L., Benning, C., Garavito, R.M.

To be published

Released	2003-07-01
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Arabidopsis thaliana
Macromolecule	SULFOLIPID BIOSYNTHESIS PROTEIN SQD1 (protein)
Unique Ligands	NAD, SO4, UPG, USQ

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1I2C \| pdb_00001i2c	Download File View File

CRYSTAL STRUCTURE OF MUTANT T145A SQD1 PROTEIN COMPLEX WITH NAD AND UDP-GLUCOSE

Theisen, M.J., Sanda, S.L., Ginell, S.L., Benning, C., Garavito, R.M.

To be published

Released	2003-07-01
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Arabidopsis thaliana
Macromolecule	SULFOLIPID BIOSYNTHESIS PROTEIN SQD1 (protein)
Unique Ligands	NAD, SO4, UPG

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1IGX \| pdb_00001igx	Download File View File

Crystal Structure of Eicosapentanoic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.

Malkowski, M.G., Thuresson, E.D., Smith, W.L., Garavito, R.M.

(2001) J Biological Chem 276: 37547-37555

Released	2001-12-12
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Ovis aries
Macromolecule	Prostaglandin Endoperoxide H Synthase-1 (protein)
Unique Ligands	BGC, BOG, COH, EPA
Unique branched monosaccharides	BMA, MAN, NAG, NDG

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1IGZ \| pdb_00001igz	Download File View File

Crystal Structure of Linoleic acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.

Malkowski, M.G., Thuresson, E.D., Smith, W.L., Garavito, R.M.

(2001) J Biological Chem 276: 37547-37555

Released	2001-12-12
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Ovis aries
Macromolecule	Prostaglandin Endoperoxide H Synthase-1 (protein)
Unique Ligands	BGC, BOG, COH, EIC
Unique branched monosaccharides	BMA, MAN, NAG, NDG

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1IIR \| pdb_00001iir	Download File View File

Crystal Structure of UDP-glucosyltransferase GtfB

Mulichak, A.M., Losey, H.C., Walsh, C.T., Garavito, R.M.

(2001) Structure 9: 547-557

Released	2001-07-18
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Amycolatopsis orientalis
Macromolecule	glycosyltransferase GtfB (protein)
Unique Ligands	MG, SO4

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1N7G \| pdb_00001n7g	Download File View File

Crystal Structure of the GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDP-rhamnose.

Mulichak, A.M., Bonin, C.P., Reiter, W.-D., Garavito, R.M.

(2002) Biochemistry 41: 155578-155589

Released	2003-01-07
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Arabidopsis thaliana
Macromolecule	GDP-D-mannose-4,6-dehydratase (protein)
Unique Ligands	GDR, NDP

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1N7H \| pdb_00001n7h	Download File View File

Crystal Structure of GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDP

Mulichak, A.M., Bonin, C.P., Reiter, W.-D., Garavito, R.M.

(2002) Biochemistry 41: 15578-15589

Released	2003-01-07
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Arabidopsis thaliana
Macromolecule	GDP-D-mannose-4,6-dehydratase (protein)
Unique Ligands	GDP, NDP

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1PEF \| pdb_00001pef	Download File View File

PEPTIDE F (EQLLKALEFLLKELLEKL), AMPHIPHILIC OCTADECAPEPTIDE

Garavito, R.M., Taylor, K., Yang, N.C.

(1996) Protein Sci 5: 414-421

Released	1996-12-07
Method	X-RAY DIFFRACTION 1.5 Å
Macromolecule	PEPTIDE F (EQLLKALEFLLKELLEKL) (protein)

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1PGE \| pdb_00001pge	Download File View File

PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH P-(2'-IODO-5'-THENOYL)HYDROTROPIC ACID (IODOSUPROFEN)

Loll, P.J., Picot, D., Garavito, R.M.

(1996) Biochemistry 35: 7330-7340

Released	1997-01-11
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Ovis aries
Macromolecule	PROSTAGLANDIN H2 SYNTHASE-1 (protein)
Unique Ligands	BOG, HEM, ISF, NAG
Unique branched monosaccharides	NAG

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1PGF \| pdb_00001pgf	Download File View File

PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL

Loll, P.J., Picot, D., Garavito, R.M.

(1996) Biochemistry 35: 7330-7340

Released	1997-01-11
Method	X-RAY DIFFRACTION 4.5 Å
Organisms	Ovis aries
Macromolecule	PROSTAGLANDIN H2 SYNTHASE-1 (protein)
Unique Ligands	HEM, IMM, NAG
Unique branched monosaccharides	NAG

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1PGG \| pdb_00001pgg	Download File View File

PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), TRANS MODEL

Loll, P.J., Picot, D., Garavito, R.M.

(1996) Biochemistry 35: 7330-7340

Released	1997-01-11
Method	X-RAY DIFFRACTION 4.5 Å
Organisms	Ovis aries
Macromolecule	PROSTAGLANDIN H2 SYNTHASE-1 (protein)
Unique Ligands	HEM, IMM, NAG
Unique branched monosaccharides	NAG

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1PN3 \| pdb_00001pn3	Download File View File

Crystal Structure of TDP-epi-Vancosaminyltransferase GtfA in complexes with TDP and the acceptor substrate DVV.

Mulichak, A.M., Losey, H.C., Lu, W., Wawrzak, Z., Walsh, C.T., Garavito, R.M.

(2003) Proc Natl Acad Sci U S A 100: 9238

Released	2003-08-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Amycolatopsis orientalis
Macromolecule	DESVANCOSAMINYL VANCOMYCIN (protein) GLYCOSYLTRANSFERASE GTFA (protein)
Unique Ligands	BGC, TYD

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1PNV \| pdb_00001pnv	Download File View File

Crystal Structure of TDP-epi-Vancosaminyltransferase GtfA in complexes with TDP and Vancomycin

Mulichak, A.M., Losey, H.C., Lu, W., Wawrzak, Z., Walsh, C.T., Garavito, R.M.

(2003) Proc Natl Acad Sci U S A 100: 9238

Released	2003-08-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Amycolatopsis orientalis
Macromolecule	GLYCOSYLTRANSFERASE GTFA (protein) VANCOMYCIN (protein)
Unique Ligands	TYD
Unique branched monosaccharides	BGC, RER

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1PRH \| pdb_00001prh	Download File View File

THE X-RAY CRYSTAL STRUCTURE OF THE MEMBRANE PROTEIN PROSTAGLANDIN H2 SYNTHASE-1

Picot, D., Loll, P.J., Garavito, R.M.

(1994) Nature 367: 243-249

Released	1995-03-31
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Ovis aries
Macromolecule	PROSTAGLANDIN H2 SYNTHASE-1 (protein)
Unique Ligands	HEM

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1PTH \| pdb_00001pth	Download File View File

The Structural Basis of Aspirin Activity Inferred from the Crystal Structure of Inactivated Prostaglandin H2 Synthase

Loll, P.J., Picot, D., Garavito, R.M.

(1995) Nat Struct Biol 2: 637-643

Released	1996-04-11
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	Ovis aries
Macromolecule	PROSTAGLANDIN H2 SYNTHASE-1 (protein)
Unique Ligands	BOG, HEM, NAG, SAL
Unique branched monosaccharides	NAG

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1QRR \| pdb_00001qrr	Download File View File

CRYSTAL STRUCTURE OF SQD1 PROTEIN COMPLEX WITH NAD AND UDP-GLUCOSE

Mulichak, A.M., Theisen, M.J., Essigmann, B., Benning, C., Garavito, R.M.

(1999) Proc Natl Acad Sci U S A 96: 13097-13102

Released	1999-11-10
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Arabidopsis thaliana
Macromolecule	sulfolipid biosynthesis (SQD1) PROTEIN (protein)
Unique Ligands	NAD, SO4, UPG

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1RPN \| pdb_00001rpn	Download File View File

Crystal Structure of GDP-D-mannose 4,6-dehydratase in complexes with GDP and NADPH

Webb, N.A., Mulichak, A.M., Lam, J.S., Rocchetta, H.L., Garavito, R.M.

(2004) Protein Sci 13: 529-539

Released	2004-02-24
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Pseudomonas aeruginosa
Macromolecule	GDP-mannose 4,6-dehydratase (protein)
Unique Ligands	GDP, NDP

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1RRV \| pdb_00001rrv	Download File View File

X-ray crystal structure of TDP-vancosaminyltransferase GtfD as a complex with TDP and the natural substrate, desvancosaminyl vancomycin.

Mulichak, A.M., Lu, W., Losey, H.C., Walsh, C.T., Garavito, R.M.

(2004) Biochemistry 43: 5170

Released	2004-05-18
Method	X-RAY DIFFRACTION 2 Å
Organisms	Amycolatopsis orientalis
Macromolecule	DESVANCOSAMINYL VANCOMYCIN (protein) GLYCOSYLTRANSFERASE GTFD (protein)
Unique Ligands	BGC, GOL, K, TYD

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1U67 \| pdb_00001u67	Download File View File

Crystal Structure of Arachidonic Acid Bound to a Mutant of Prostagladin H Synthase-1 that Forms Predominantly 11-HPETE.

Harman, C.A., Rieke, C.J., Garavito, R.M., Smith, W.L.

(2004) J Biological Chem 279: 42929-42935

Released	2004-09-07
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Ovis aries
Macromolecule	Prostaglandin G/H synthase 1 precursor (protein)
Unique Ligands	ACD, BOG, COH
Unique branched monosaccharides	BMA, NAG, NDG

1 to 25 of 45 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1BDG | pdb_00001bdg

1BG3 | pdb_00001bg3

1CQE | pdb_00001cqe

1DIY | pdb_00001diy

1FE2 | pdb_00001fe2

1I24 | pdb_00001i24

1I2B | pdb_00001i2b

1I2C | pdb_00001i2c

1IGX | pdb_00001igx

1IGZ | pdb_00001igz

1IIR | pdb_00001iir

1N7G | pdb_00001n7g

1N7H | pdb_00001n7h

1PEF | pdb_00001pef

1PGE | pdb_00001pge

1PGF | pdb_00001pgf

1PGG | pdb_00001pgg

1PN3 | pdb_00001pn3

1PNV | pdb_00001pnv

1PRH | pdb_00001prh

1PTH | pdb_00001pth

1QRR | pdb_00001qrr

1RPN | pdb_00001rpn

1RRV | pdb_00001rrv

1U67 | pdb_00001u67