RCSB PDB: Search

1Q24 \| pdb_00001q24	Download File View File

PKA double mutant model of PKB in complex with MgATP

Gassel, M., Breitenlechner, C.B., Rueger, P., Jucknischke, U., Schneider, T., Huber, R., Bossemeyer, D., Engh, R.A.

(2003) J Mol Biology 329: 1021-1034

Released	2003-08-19
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Bos taurus Sus scrofa
Macromolecule	cAMP-dependent Protein Kinase Inhibitor, alpha form (protein) cAMP-dependent Protein Kinase, alpha-catalytic subunit (protein)
Unique Ligands	ATP, MG

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1Q61 \| pdb_00001q61	Download File View File

PKA triple mutant model of PKB

Gassel, M., Breitenlechner, C.B., Rueger, P., Jucknischke, U., Schneider, T., Huber, R., Bossemeyer, D., Engh, R.A.

(2003) J Mol Biology 329: 1021-1034

Released	2003-09-30
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	MG8

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1Q62 \| pdb_00001q62	Download File View File

PKA double mutant model of PKB

Gassel, M., Breitenlechner, C.B., Rueger, P., Jucknischke, U., Schneider, T., Huber, R., Bossemeyer, D., Engh, R.A.

(2003) J Mol Biology 329: 1021-1034

Released	2003-09-30
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)

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1Q8T \| pdb_00001q8t	Download File View File

The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632

Breitenlechner, C., Gassel, M., Hidaka, H., Kinzel, V., Huber, R., Engh, R.A., Bossemeyer, D.

(2003) Structure 11: 1595-1607

Released	2003-12-16
Method	X-RAY DIFFRACTION 2 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	Y27

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1Q8U \| pdb_00001q8u	Download File View File

The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P

Breitenlechner, C., Gassel, M., Hidaka, H., Kinzel, V., Huber, R., Engh, R.A., Bossemeyer, D.

(2003) Structure 11: 1595-1607

Released	2003-12-16
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Bos taurus Rattus norvegicus
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	H52, MG8

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1Q8W \| pdb_00001q8w	Download File View File

The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077)

Breitenlechner, C., Gassel, M., Hidaka, H., Kinzel, V., Huber, R., Engh, R.A., Bossemeyer, D.

(2003) Structure 11: 1595-1607

Released	2003-12-16
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Bos taurus Oryctolagus cuniculus
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	M77

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1SMH \| pdb_00001smh	Download File View File

Protein kinase A variant complex with completely ordered N-terminal helix

Breitenlechner, C., Engh, R.A., Huber, R., Kinzel, V., Bossemeyer, D., Gassel, M.

(2004) Biochemistry 43: 7743-7749

Released	2004-07-06
Method	X-RAY DIFFRACTION 2.044 Å
Organisms	Bos taurus Oryctolagus cuniculus
Macromolecule	cAMP-Dependent Protein Kinase, alpha-catalytic subunit (protein) cAMP-dependent protein kinase inhibitor, alpha form (protein)
Unique Ligands	BU3, MG8

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1SZM \| pdb_00001szm	Download File View File

DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA)

Gassel, M., Breitenlechner, C.B., Koenig, N., Huber, R., Engh, R.A., Bossemeyer, D.

(2004) J Biological Chem 279: 23679-23690

Released	2004-06-01
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Bos taurus
Macromolecule	cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	BI4

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1XH4 \| pdb_00001xh4	Download File View File

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Breitenlechner, C.B., Friebe, W.-G., Brunet, E., Werner, G., Graul, K., Thomas, U., Kuenkele, K.-P., Schaefer, W., Gassel, M., Bossemeyer, D., Huber, R., Engh, R.A., Masjost, B.

(2005) J Med Chem 48: 163-170

Released	2005-09-17
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Bos taurus synthetic construct
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	R69

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1XH5 \| pdb_00001xh5	Download File View File

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Breitenlechner, C.B., Friebe, W.-G., Brunet, E., Werner, G., Graul, K., Thomas, U., Kuenkele, K.-P., Schaefer, W., Gassel, M., Bossemeyer, D., Huber, R., Engh, R.A., Masjost, B.

(2005) J Med Chem 48: 163-170

Released	2005-09-17
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Bos taurus synthetic construct
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	BU3, R68

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1XH6 \| pdb_00001xh6	Download File View File

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Breitenlechner, C.B., Friebe, W.-G., Brunet, E., Werner, G., Graul, K., Thomas, U., Kuenkele, K.-P., Schaefer, W., Gassel, M., Bossemeyer, D., Huber, R., Engh, R.A., Masjost, B.

(2005) J Med Chem 48: 163-170

Released	2005-09-17
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Bos taurus synthetic construct
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	R94

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1XH7 \| pdb_00001xh7	Download File View File

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Breitenlechner, C.B., Friebe, W.-G., Brunet, E., Werner, G., Graul, K., Thomas, U., Kuenkele, K.-P., Schaefer, W., Gassel, M., Bossemeyer, D., Huber, R., Engh, R.A., Masjost, B.

(2005) J Med Chem 48: 163-170

Released	2005-09-17
Method	X-RAY DIFFRACTION 2.47 Å
Organisms	Bos taurus synthetic construct
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	R96

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1XH8 \| pdb_00001xh8	Download File View File

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Breitenlechner, C.B., Friebe, W.-G., Brunet, E., Werner, G., Graul, K., Thomas, U., Kuenkele, K.-P., Schaefer, W., Gassel, M., Bossemeyer, D., Huber, R., Engh, R.A., Masjost, B.

(2005) J Med Chem 48: 163-170

Released	2005-09-17
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Bos taurus synthetic construct
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	R55

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1XH9 \| pdb_00001xh9	Download File View File

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Breitenlechner, C.B., Friebe, W.-G., Brunet, E., Werner, G., Graul, K., Thomas, U., Kuenkele, K.-P., Schaefer, W., Gassel, M., Bossemeyer, D., Huber, R., Engh, R.A., Masjost, B.

(2005) J Med Chem 48: 163-170

Released	2005-09-17
Method	X-RAY DIFFRACTION 1.64 Å
Organisms	Bos taurus synthetic construct
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	BU3, R69

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1XHA \| pdb_00001xha	Download File View File

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Breitenlechner, C.B., Friebe, W.-G., Brunet, E., Werner, G., Graul, K., Thomas, U., Kuenkele, K.-P., Schaefer, W., Gassel, M., Bossemeyer, D., Huber, R., Engh, R.A., Masjost, B.

(2005) J Med Chem 48: 163-170

Released	2005-09-17
Method	X-RAY DIFFRACTION 2.46 Å
Organisms	Bos taurus synthetic construct
Macromolecule	cAMP-dependent protein kinase inhibitor, alpha form (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	R68

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2GFC \| pdb_00002gfc	Download File View File

cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24

Bonn, S., Herrero, S., Breitenlechner, C.B., Engh, R.A., Gassel, M., Bossemeyer, D.

(2006) J Biological Chem 281: 24818-24830

Released	2006-05-23
Method	X-RAY DIFFRACTION 1.87 Å
Organisms	Bos taurus Oryctolagus cuniculus
Macromolecule	cAMP-dependent protein kinase inhibitor alpha (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	OCT

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2GNF \| pdb_00002gnf	Download File View File

Protein kinase A fivefold mutant model of Rho-kinase with Y-27632

Bonn, S., Herrero, S., Breitenlechner, C.B., Engh, R.A., Gassel, M., Bossemeyer, D.

(2006) J Biological Chem 281: 24818-24830

Released	2006-05-23
Method	X-RAY DIFFRACTION 2.28 Å
Organisms	Bos taurus Mus musculus
Macromolecule	cAMP-dependent protein kinase inhibitor alpha (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	Y27

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2GNG \| pdb_00002gng	Download File View File

Protein kinase A fivefold mutant model of Rho-kinase

Bonn, S., Herrero, S., Breitenlechner, C.B., Engh, R.A., Gassel, M., Bossemeyer, D.

(2006) J Biological Chem 281: 24818-24830

Released	2006-05-23
Method	X-RAY DIFFRACTION 1.87 Å
Organisms	Bos taurus Mus musculus
Macromolecule	cAMP-dependent protein kinase inhibitor alpha (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)

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2GNH \| pdb_00002gnh	Download File View File

PKA five fold mutant model of Rho-kinase with H1152P

Bonn, S., Herrero, S., Breitenlechner, C.B., Engh, R.A., Gassel, M., Bossemeyer, D.

(2006) J Biological Chem 281: 24818-24830

Released	2006-05-23
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Bos taurus Oryctolagus cuniculus
Macromolecule	cAMP-dependent protein kinase inhibitor alpha (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	H52

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2GNI \| pdb_00002gni	Download File View File

PKA fivefold mutant model of Rho-kinase with inhibitor Fasudil (HA1077)

Bonn, S., Herrero, S., Breitenlechner, C.B., Engh, R.A., Gassel, M., Bossemeyer, D.

(2006) J Biological Chem 281: 24818-24830

Released	2006-05-23
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	cAMP-dependent protein kinase inhibitor alpha (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	M77

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2GNJ \| pdb_00002gnj	Download File View File

PKA three fold mutant model of Rho-kinase with Y-27632

Bonn, S., Herrero, S., Breitenlechner, C.B., Engh, R.A., Gassel, M., Bossemeyer, D.

(2006) J Biological Chem 281: 24818-24830

Released	2006-05-23
Method	X-RAY DIFFRACTION 2.28 Å
Organisms	Bos taurus Oryctolagus cuniculus
Macromolecule	cAMP-dependent protein kinase inhibitor alpha (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	Y27

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2GNL \| pdb_00002gnl	Download File View File

PKA threefold mutant model of Rho-kinase with inhibitor H-1152P

Bonn, S., Herrero, S., Breitenlechner, C.B., Engh, R.A., Gassel, M., Bossemeyer, D.

(2006) J Biological Chem 281: 24818-24830

Released	2006-05-23
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Bos taurus Oryctolagus cuniculus
Macromolecule	cAMP-dependent protein kinase inhibitor alpha (protein) cAMP-dependent protein kinase, alpha-catalytic subunit (protein)
Unique Ligands	H52

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1Q24 | pdb_00001q24

1Q61 | pdb_00001q61

1Q62 | pdb_00001q62

1Q8T | pdb_00001q8t

1Q8U | pdb_00001q8u

1Q8W | pdb_00001q8w

1SMH | pdb_00001smh

1SZM | pdb_00001szm

1XH4 | pdb_00001xh4

1XH5 | pdb_00001xh5

1XH6 | pdb_00001xh6

1XH7 | pdb_00001xh7

1XH8 | pdb_00001xh8

1XH9 | pdb_00001xh9

1XHA | pdb_00001xha

2GFC | pdb_00002gfc

2GNF | pdb_00002gnf

2GNG | pdb_00002gng

2GNH | pdb_00002gnh

2GNI | pdb_00002gni

2GNJ | pdb_00002gnj

2GNL | pdb_00002gnl