RCSB PDB: Search

4PID \| pdb_00004pid	Download File View File

Crystal structure of human adenovirus 2 protease with a weak pyrimidine nitrile inhibitor

Mac Sweeney, A., Grosche, P., Ellis, D., Combrink, K., Erbel, P., Hughes, N., Sirockin, F., Melkko, S., Bernardi, A., Ramage, P., Jarousse, N., Altmann, E.

(2014) ACS Med Chem Lett 5: 937-941

Released	2014-09-10
Method	X-RAY DIFFRACTION 1.59 Å
Organisms	Human adenovirus 2
Macromolecule	Pre-protein VI (protein) Protease (protein)
Unique Ligands	2UQ, ACT

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4PIE \| pdb_00004pie	Download File View File

Crystal structure of human adenovirus 2 protease a substrate based nitrile inhibitor

Mac Sweeney, A., Grosche, P., Ellis, D., Combrink, C., Erbel, C., Hughes, N., Sirockin, F., Melkko, S., Bernardi, A., Ramage, P., Jarousse, N., Altmann, E.

(2014) ACS Med Chem Lett 5: 937-941

Released	2014-09-10
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Human adenovirus 2
Macromolecule	Pre-protein VI (protein) Protease (protein)
Unique Ligands	3FO, ACT, SO4, ZN

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4PIQ \| pdb_00004piq	Download File View File

Crystal structure of human adenovirus 8 protease with a nitrile inhibitor

Mac Sweeney, A., Grosche, P., Ellis, D., Combrink, K., Erbel, P., Hughes, N., Sirockin, F., Melkko, S., Bernardi, A., Ramage, P., Jarousse, N., Altmann, E.

(2014) ACS Med Chem Lett 5: 937-941

Released	2014-09-10
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Human adenovirus D8
Macromolecule	PVI (protein) Protease (protein)
Unique Ligands	3FS

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4PIS \| pdb_00004pis	Download File View File

Crystal structure of human adenovirus 8 protease in complex with a nitrile inhibitor

Mac Sweeney, A., Grosche, P., Ellis, D., Combrink, K., Erbel, P., Hughes, N., Sirockin, F., Melkko, S., Bernardi, A., Ramage, P., Jarousse, N., Altmann, E.

(2014) ACS Med Chem Lett 5: 937-941

Released	2014-09-10
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Human adenovirus D8
Macromolecule	PVI (protein) Protease (protein)
Unique Ligands	3FU

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4WX4 \| pdb_00004wx4	Download File View File

Crystal structure of adenovirus 8 protease in complex with a nitrile inhibitor

Grosche, P., Sirockin, F., Mac Sweeney, A., Ramage, P., Erbel, P., Melkko, S., Bernardi, A., Hughes, N., Ellis, D., Combrink, K., Jarousse, N., Altmann, E.

(2015) Bioorg Med Chem Lett 25: 438-443

Released	2015-01-14
Method	X-RAY DIFFRACTION 1.03 Å
Organisms	Human adenovirus D8 synthetic construct
Macromolecule	Protease (protein) peptide (protein)
Unique Ligands	3VF, EPE, GLY

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4WX6 \| pdb_00004wx6	Download File View File

Crystal structure of human adenovirus 8 protease with an irreversible vinyl sulfone inhibitor

Grosche, P., Sirockin, F., Mac Sweeney, A., Ramage, P., Erbel, P., Melkko, S., Bernardi, A., Hughes, N., Ellis, D., Combrink, K., Jarousse, N., Altmann, E.

(2015) Bioorg Med Chem Lett 25: 438-443

Released	2015-01-14
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Human adenovirus D8
Macromolecule	PVI (protein) Protease (protein)
Unique Ligands	3VK

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4WX7 \| pdb_00004wx7	Download File View File

Crystal structure of adenovirus 8 protease with a nitrile inhibitor

Grosche, P., Sirockin, F., Mac Sweeney, A., Ramage, P., Erbel, P., Melkko, S., Bernardi, A., Hughes, N., Ellis, D., Combrink, K., Jarousse, N., Altmann, E.

(2015) Bioorg Med Chem Lett 25: 438-443

Released	2015-01-14
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Human adenovirus D8
Macromolecule	PVI (protein) Protease (protein)
Unique Ligands	3VJ

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6QSW \| pdb_00006qsw	Download File View File

Complement factor B protease domain in complex with the reversible inhibitor N-(2-bromo-4-methylnaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine.

Adams, C.M., Sellner, H., Ehara, T., Mac Sweeney, A., Crowley, M., Anderson, K., Karki, R., Mainolfi, N., Valeur, E., Sirockin, F., Gerhartz, B., Erbel, P., Hughes, N., Smith, T.M., Cumin, F., Argikar, U., Mogi, M., Sedrani, R., Wiesmann, C., Jaffee, B., Maibaum, J., Flohr, S., Harrison, R., Eder, J.

(2019) Proc Natl Acad Sci U S A 116: 7926-7931

Released	2019-03-27
Method	X-RAY DIFFRACTION 1.64 Å
Organisms	Homo sapiens
Macromolecule	Complement factor B (protein)
Unique Ligands	JGT, SO4

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6QSX \| pdb_00006qsx	Download File View File

Complement factor B protease domain in complex with the reversible inhibitor ((2S,4S)-1-((5,7-dimethyl-1H-indol-4-yl)methyl)-4-methoxypiperidin-2-yl)methanol.

Adams, C.M., Sellner, H., Ehara, T., Mac Sweeney, A., Crowley, M., Anderson, K., Karki, R., Mainolfi, N., Valeur, E., Sirockin, F., Gerhartz, B., Erbel, P., Hughes, N., Smith, T.M., Cumin, F., Argikar, U., Mogi, M., Sedrani, R., Wiesmann, C., Jaffee, B., Maibaum, J., Flohr, S., Harrison, R., Eder, J.

(2019) Proc Natl Acad Sci U S A 116: 7926-7931

Released	2019-03-27
Method	X-RAY DIFFRACTION 1.77 Å
Organisms	Homo sapiens
Macromolecule	Complement factor B (protein)
Unique Ligands	JGN, SO4, ZN

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6RAV \| pdb_00006rav	Download File View File

Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid

Adams, C.M., Sellner, H., Ehara, T., Mac Sweeney, A., Crowley, M., Anderson, K., Karki, R., Mainolfi, N., Valeur, E., Sirockin, F., Gerhartz, B., Erbel, P., Hughes, N., Smith, T.M., Cumin, F., Argikar, U., Mogi, M., Sedrani, R., Wiesmann, C., Jaffee, B., Maibaum, J., Flohr, S., Harrison, R., Eder, J.

(2019) Proc Natl Acad Sci U S A 116: 7926-7931

Released	2019-04-17
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Complement factor B (protein)
Unique Ligands	JGQ, SO4, ZN

4PID | pdb_00004pid

Crystal structure of human adenovirus 2 protease with a weak pyrimidine nitrile inhibitor

4PIE | pdb_00004pie

Crystal structure of human adenovirus 2 protease a substrate based nitrile inhibitor

4PIQ | pdb_00004piq

Crystal structure of human adenovirus 8 protease with a nitrile inhibitor

4PIS | pdb_00004pis

Crystal structure of human adenovirus 8 protease in complex with a nitrile inhibitor

4WX4 | pdb_00004wx4

Crystal structure of adenovirus 8 protease in complex with a nitrile inhibitor

4WX6 | pdb_00004wx6

Crystal structure of human adenovirus 8 protease with an irreversible vinyl sulfone inhibitor

4WX7 | pdb_00004wx7

Crystal structure of adenovirus 8 protease with a nitrile inhibitor

6QSW | pdb_00006qsw

Complement factor B protease domain in complex with the reversible inhibitor N-(2-bromo-4-methylnaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine.

6QSX | pdb_00006qsx

Complement factor B protease domain in complex with the reversible inhibitor ((2S,4S)-1-((5,7-dimethyl-1H-indol-4-yl)methyl)-4-methoxypiperidin-2-yl)methanol.

6RAV | pdb_00006rav

Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid

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4PID | pdb_00004pid

4PIE | pdb_00004pie

4PIQ | pdb_00004piq

4PIS | pdb_00004pis

4WX4 | pdb_00004wx4

4WX6 | pdb_00004wx6

4WX7 | pdb_00004wx7

6QSW | pdb_00006qsw

6QSX | pdb_00006qsx

6RAV | pdb_00006rav