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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Lax, I."

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Search Summary

This query matches 11 Structures.

Refinements

Structure Determination Methodology

experimental (11)

Scientific Name of Source Organism

	Homo sapiens (11)
	Mus musculus (1)
	Rattus norvegicus (1)

Taxonomy

Eukaryota (11)

Experimental Method

X-RAY DIFFRACTION (11)

Polymer Entity Type

Protein (11)

Refinement Resolution (Å)

	2.0 - 2.5 (2)
	2.5 - 3.0 (4)
	3.0 - 3.5 (4)
	3.5 - 4.0 (1)

Release Date

	1995 - 1999 (2)
	2005 - 2009 (4)
	2010 - 2014 (4)
	2015 - 2019 (1)

Enzyme Classification Name

	Transferases (9)
	Hydrolases (1)

Symmetry Type

	Asymmetric (7)
	Cyclic (6)

SCOP Classification

	All beta proteins (4)
	Alpha and beta proteins (a+b) (3)
	Artifacts (2)
	All alpha proteins (1)

AllSelected

1 to 11 of 11 Structures

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1AXM \| pdb_00001axm	Download File View File

HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR

DiGabriele, A.D., Lax, I., Chen, D.I., Svahn, C.M., Jaye, M., Schlessinger, J., Hendrickson, W.A.

(1998) Nature 393: 812-817

Released	1998-04-22
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	ACIDIC FIBROBLAST GROWTH FACTOR (protein)
Unique branched monosaccharides	IDS, SGN

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2AXM \| pdb_00002axm	Download File View File

HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR

Digabriele, A.D., Lax, I., Chen, D.I., Svahn, C.M., Jaye, M., Schlessinger, J., Hendrickson, W.A.

(1998) Nature 393: 812-817

Released	1998-04-22
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	ACIDIC FIBROBLAST GROWTH FACTOR (protein)
Unique branched monosaccharides	IDS, SGN

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2E9W \| pdb_00002e9w	Download File View File

Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF)

Yuzawa, S., Opatowsky, Y., Zhang, Z., Mandiyan, V., Lax, I., Schlessinger, J.

(2007) Cell 130: 323-334

Released	2007-08-07
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Homo sapiens
Macromolecule	Kit ligand (protein) Mast/stem cell growth factor receptor (protein)
Unique Ligands	NAG

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2EC8 \| pdb_00002ec8	Download File View File

Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit

Yuzawa, S., Opatowsky, Y., Zhang, Z., Mandiyan, V., Lax, I., Schlessinger, J.

(2007) Cell 130: 323-334

Released	2007-08-07
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Mast/stem cell growth factor receptor (protein)
Unique Ligands	NAG

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3GQI \| pdb_00003gqi	Download File View File

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

Bae, J.H., Lew, E.D., Yuzawa, S., Tome, F., Lax, I., Schlessinger, J.

(2009) Cell 138: 514-524

Released	2009-08-18
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens Rattus norvegicus
Macromolecule	Basic fibroblast growth factor receptor 1 (protein) Phospholipase C-gamma-1 (protein)
Unique Ligands	ACP, DVT, MG

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3GQL \| pdb_00003gql	Download File View File

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

Bae, J.H., Lew, E.D., Yuzawa, S., Tome, F., Lax, I., Schlessinger, J.

(2009) Cell 138: 514-524

Released	2009-08-18
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein)
Unique Ligands	GQL

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3KXX \| pdb_00003kxx	Download File View File

Structure of the mutant Fibroblast Growth Factor receptor 1

Bae, J.H., Boggon, T.J., Tome, F., Mandiyan, V., Lax, I., Schlessinger, J.

(2010) Proc Natl Acad Sci U S A 107: 2866-2871

Released	2010-03-02
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein)

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3KY2 \| pdb_00003ky2	Download File View File

Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain

Bae, J.H., Boggon, T.J., Tome, F., Mandiyan, V., Lax, I., Schlessinger, J.

(2010) Proc Natl Acad Sci U S A 107: 2866-2871

Released	2010-03-02
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein)
Unique Ligands	SO4

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4K94 \| pdb_00004k94	Download File View File

Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19

Resheynyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J.

(2013) Proc Natl Acad Sci U S A 110: 17832-17837

Released	2013-10-16
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Fab19 heavy chain (protein) Fab19 light chain (protein) Mast/stem cell growth factor receptor Kit (protein)
Unique Ligands	NAG

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4K9E \| pdb_00004k9e	Download File View File

Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D

Resheynyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J.

(2013) Proc Natl Acad Sci U S A 110: 17832-17837

Released	2013-10-16
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Mast/stem cell growth factor receptor Kit (protein) heavy chain (protein) light chain (protein)
Unique Ligands	NAG

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4PGZ \| pdb_00004pgz	Download File View File

Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation

Reshetnyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J.

(2015) Mol Cell 57: 191-201

Released	2015-03-18
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Mast/stem cell growth factor receptor Kit (protein)
Unique Ligands	CO, NAG

1 to 11 of 11 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1AXM | pdb_00001axm

HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR

2AXM | pdb_00002axm

HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR

2E9W | pdb_00002e9w

Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF)

2EC8 | pdb_00002ec8

Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit

3GQI | pdb_00003gqi

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

3GQL | pdb_00003gql

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

3KXX | pdb_00003kxx

Structure of the mutant Fibroblast Growth Factor receptor 1

3KY2 | pdb_00003ky2

Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain

4K94 | pdb_00004k94

Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19

4K9E | pdb_00004k9e

Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D

4PGZ | pdb_00004pgz

Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1AXM | pdb_00001axm

2AXM | pdb_00002axm

2E9W | pdb_00002e9w

2EC8 | pdb_00002ec8

3GQI | pdb_00003gqi

3GQL | pdb_00003gql

3KXX | pdb_00003kxx

3KY2 | pdb_00003ky2

4K94 | pdb_00004k94

4K9E | pdb_00004k9e

4PGZ | pdb_00004pgz