RCSB PDB: Search

1FM6 \| pdb_00001fm6	Download File View File

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND ROSIGLITAZONE AND CO-ACTIVATOR PEPTIDES.

Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Miller, A.B., Bledsoe, R.K., Milburn, M.V., Kliewer, S.A., Willson, T.M., Xu, H.E.

(2000) Mol Cell 5: 545-555

Released	2001-02-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (protein) RETINOIC ACID RECEPTOR RXR-ALPHA (protein) STEROID RECEPTOR COACTIVATOR (protein)
Unique Ligands	9CR, BRL

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1FM9 \| pdb_00001fm9	Download File View File

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES.

Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Miller, A.B., Bledsoe, R.K., Milburn, M.V., Kliewer, S.A., Willson, T.M., Xu, H.E.

(2000) Mol Cell 5: 545-555

Released	2001-02-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (protein) RETINOIC ACID RECEPTOR RXR-ALPHA (protein) STEROID RECEPTOR COACTIVATOR (protein)
Unique Ligands	570, 9CR

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1LV2 \| pdb_00001lv2	Download File View File

Hepatocyte Nuclear Factor 4 is a Transcription Factor that Constitutively Binds Fatty Acids

Wisely, B., Miller, A.B., Davis, R.G., Spitzer, T., Shearer, B., Moore, J.T., Johnson, R., Sefler, A., Willson, T.M., Williams, S.P.

(2002) Structure 10: 1225-1234

Released	2002-12-18
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte nuclear factor 4-gamma (protein)
Unique Ligands	PLM

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1P8D \| pdb_00001p8d	Download File View File

X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol

Williams, S., Bledsoe, R.K., Collins, J.L., Boggs, S., Lambert, M.H., Miller, A.B., Moore, J., McKee, D.D., Moore, L., Nichols, J., Parks, D., Watson, M., Wisely, B., Willson, T.M.

(2003) J Biological Chem 278: 27138-27143

Released	2003-07-08
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Oxysterols receptor LXR-beta (protein) nuclear receptor coactivator 1 isoform 3 (protein)
Unique Ligands	CO1

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1Q6K \| pdb_00001q6k	Download File View File

Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate

Catalano, J.G., Deaton, D.N., Furfine, E.S., Hassell, A.M., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M., Willard, D.H., Wright, L.L.

(2004) Bioorg Med Chem Lett 14: 275-278

Released	2004-03-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	SO4, TCO

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1RDT \| pdb_00001rdt	Download File View File

Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer

Haffner, C.D., Lenhard, J.M., Miller, A.B., McDougald, D.L., Dwornik, K., Ittoop, O.R., Gampe Jr., R.T., Xu, H.E., Blanchard, S., Montana, V.G.

(2004) J Med Chem 47: 2010-2029

Released	2004-11-09
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	LxxLL motif coactivator (protein) Peroxisome proliferator activated receptor gamma (protein) Retinoic acid receptor RXR-alpha (protein)
Unique Ligands	570, L79

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1SNK \| pdb_00001snk	Download File View File

Cathepsin K complexed with carbamate derivatized norleucine aldehyde

Boros, E.E., Deaton, D.N., Hassell, A.M., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M., Thompson, J.B., Willard Jr., D.H., Wright, L.L.

(2004) Bioorg Med Chem Lett 14: 3425-3429

Released	2004-06-22
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	MYE, SO4

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1TU6 \| pdb_00001tu6	Download File View File

Cathepsin K complexed with a ketoamide inhibitor

Barrett, D.G., Catalano, J.G., Deaton, D.N., Hassell, A.M., Long, S.T., Miller, A.B., Miller, L.R., Shewchuk, L.M., Wells-Knecht, K.J., Wright, L.L.

(2004) Bioorg Med Chem Lett 14: 4897-4902

Released	2004-09-21
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	FSP, SO4

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1YK7 \| pdb_00001yk7	Download File View File

Cathepsin K complexed with a cyanopyrrolidine inhibitor

Barrett, D.G., Deaton, D.N., Hassell, A.M., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M., Tavares, F.X., Willard, D.H., Wright, L.L.

(2005) Bioorg Med Chem Lett 15: 1815-1819

Released	2005-03-22
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	NBL

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1YK8 \| pdb_00001yk8	Download File View File

Cathepsin K complexed with a cyanamide-based inhibitor

Barrett, D.G., Deaton, D.N., Hassell, A.M., McFadyen, R.B., Miller, A.B., Miller, L.R., Payne, J.A., Shewchuk, L.M., Willard, D.H., Wright, L.L.

(2005) Bioorg Med Chem Lett 15: 3039-3043

Released	2005-07-19
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	T2M

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1YT7 \| pdb_00001yt7	Download File View File

Cathepsin K complexed with a constrained ketoamide inhibitor

Barrett, D.G., Boncek, V.M., Catalano, J.G., Deaton, D.N., Hassell, A.M., Jurgensen, C.H., Long, S.T., McFadyen, R.B., Miller, A.B., Miller, L.R., Payne, J.A., Ray, J.A., Samano, V., Shewchuk, L.M., Tavares, F.X., Wells-Knecht, K.J., Willard, D.H., Wright, L.L., Zhou, H.Q.

(2005) Bioorg Med Chem Lett 15: 3540-3546

Released	2005-07-19
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	3FC, SO4

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2AUX \| pdb_00002aux	Download File View File

Cathepsin K complexed with a semicarbazone inhibitor

Adkison, K.K., Barrett, D.G., Deaton, D.N., Gampe, R.T., Hassell, A.M., Long, S.T., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M.

(2006) Bioorg Med Chem Lett 16: 978-983

Released	2006-08-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	CT1

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2AUZ \| pdb_00002auz	Download File View File

Cathepsin K complexed with a semicarbazone inhibitor

Adkison, K.K., Barrett, D.G., Deaton, D.N., Gampe, R.T., Hassell, A.M., Long, S.T., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M.

(2006) Bioorg Med Chem Lett 16: 978-983

Released	2006-08-08
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	CT2, SO4

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2GP7 \| pdb_00002gp7	Download File View File

Estrogen Related Receptor-gamma ligand binding domain

Wang, L., Zuercher, W.J., Consler, T.G., Lambert, M.H., Miller, A.B., Osband-miller, L.A., McKee, D.D., Willson, T.M., Nolte, R.T.

(2006) J Biological Chem 281: 37773-37781

Released	2006-09-26
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Homo sapiens
Macromolecule	Estrogen-related receptor gamma (protein)
Unique Ligands	CA

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2GPO \| pdb_00002gpo	Download File View File

Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140

Wang, L., Zuercher, W.J., Consler, T.G., Lambert, M.H., Miller, A.B., Osband-miller, L.A., McKee, D.D., Willson, T.M., Nolte, R.T.

(2006) J Biological Chem 281: 37773-37781

Released	2006-09-26
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Estrogen-related receptor gamma (protein) Nuclear receptor-interacting protein 1 (protein)

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2GPP \| pdb_00002gpp	Download File View File

Estrogen Related Receptor-gamma ligand binding domain complexed with a RIP140 peptide and synthetic ligand GSK4716

Wang, L., Zuercher, W.J., Consler, T.G., Lambert, M.H., Miller, A.B., Osband-miller, L.A., McKee, D.D., Willson, T.M., Nolte, R.T.

(2006) J Biological Chem 281: 37773-37781

Released	2006-09-26
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Estrogen-related receptor gamma (protein) Nuclear receptor-interacting protein 1 (protein)
Unique Ligands	1BA

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2GPU \| pdb_00002gpu	Download File View File

Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen

Wang, L., Zuercher, W.J., Consler, T.G., Lambert, M.H., Miller, A.B., Osband-Miller, L.A., McKee, D.D., Willson, T.M., Nolte, R.T.

(2006) J Biological Chem 281: 37773-37781

Released	2006-09-26
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Estrogen-related receptor gamma (protein)
Unique Ligands	OHT

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2GPV \| pdb_00002gpv	Download File View File

Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide

Wang, L., Zuercher, W.J., Consler, T.G., Lambert, M.H., Miller, A.B., Osband-miller, L.A., McKee, D.D., Willson, T.M., Nolte, R.T.

(2006) J Biological Chem 281: 37773-37781

Released	2006-09-26
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Homo sapiens Tetraodon nigroviridis
Macromolecule	Estrogen-related receptor gamma (protein) Nuclear receptor corepressor 2 (protein)
Unique Ligands	OHT

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3DDU \| pdb_00003ddu	Download File View File

Prolyl Oligopeptidase with GSK552

Madauss, K.P., Reid, R.A., Haffner, C.D., Miller, A.B.

(2008) Bioorg Med Chem Lett 18: 4360-4363

Released	2008-08-19
Method	X-RAY DIFFRACTION 1.56 Å
Organisms	Homo sapiens
Macromolecule	Prolyl endopeptidase (protein)
Unique Ligands	552, ACT, GOL

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3DT3 \| pdb_00003dt3	Download File View File

Human Estrogen receptor alpha LBD with GW368

Williams, S.P., Miller, A.B.

(2008) Bioorg Med Chem Lett 18: 5075-5077

Released	2008-09-09
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Estrogen receptor (protein)
Unique Ligands	369

1FM6 | pdb_00001fm6

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND ROSIGLITAZONE AND CO-ACTIVATOR PEPTIDES.

1FM9 | pdb_00001fm9

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES.

1LV2 | pdb_00001lv2

Hepatocyte Nuclear Factor 4 is a Transcription Factor that Constitutively Binds Fatty Acids

1P8D | pdb_00001p8d

X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol

1Q6K | pdb_00001q6k

Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate

1RDT | pdb_00001rdt

Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer

1SNK | pdb_00001snk

Cathepsin K complexed with carbamate derivatized norleucine aldehyde

1TU6 | pdb_00001tu6

Cathepsin K complexed with a ketoamide inhibitor

1YK7 | pdb_00001yk7

Cathepsin K complexed with a cyanopyrrolidine inhibitor

1YK8 | pdb_00001yk8

Cathepsin K complexed with a cyanamide-based inhibitor

1YT7 | pdb_00001yt7

Cathepsin K complexed with a constrained ketoamide inhibitor

2AUX | pdb_00002aux

Cathepsin K complexed with a semicarbazone inhibitor

2AUZ | pdb_00002auz

Cathepsin K complexed with a semicarbazone inhibitor

2GP7 | pdb_00002gp7

Estrogen Related Receptor-gamma ligand binding domain

2GPO | pdb_00002gpo

Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140

2GPP | pdb_00002gpp

Estrogen Related Receptor-gamma ligand binding domain complexed with a RIP140 peptide and synthetic ligand GSK4716

2GPU | pdb_00002gpu

Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen

2GPV | pdb_00002gpv

Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide

3DDU | pdb_00003ddu

Prolyl Oligopeptidase with GSK552

3DT3 | pdb_00003dt3

Human Estrogen receptor alpha LBD with GW368

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1FM6 | pdb_00001fm6

1FM9 | pdb_00001fm9

1LV2 | pdb_00001lv2

1P8D | pdb_00001p8d

1Q6K | pdb_00001q6k

1RDT | pdb_00001rdt

1SNK | pdb_00001snk

1TU6 | pdb_00001tu6

1YK7 | pdb_00001yk7

1YK8 | pdb_00001yk8

1YT7 | pdb_00001yt7

2AUX | pdb_00002aux

2AUZ | pdb_00002auz

2GP7 | pdb_00002gp7

2GPO | pdb_00002gpo

2GPP | pdb_00002gpp

2GPU | pdb_00002gpu

2GPV | pdb_00002gpv

3DDU | pdb_00003ddu

3DT3 | pdb_00003dt3