Structure Determination MethodologyScientific Name of Source OrganismRefinement Resolution (Å)Enzyme Classification NameMembrane Protein Annotation | Brauer, A.B.E., Kelly, G., McBride, J.D., Cooke, R.M., Matthews, S.J., Leatherbarrow, R.J. (2001) J Mol Biology 306: 799 | Released | 2001-03-29 | | Method | SOLUTION NMR | | Organisms | | | Macromolecule | |
Mott, H.R., Baines, B.S., Hall, R.M., Cooke, R.M., Driscoll, P.C., Weir, M.P., Campbell, I.D. (1995) J Mol Biology 247: 979-994 | Released | 1995-12-07 | | Method | SOLUTION NMR | | Organisms | | | Macromolecule | |
Hollenstein, K., Kean, J., Bortolato, A., Cheng, R.K.Y., Dore, A.S., Jazayeri, A., Cooke, R.M., Weir, M., Marshall, F.H. (2013) Nature 499: 438-443 | Released | 2013-07-17 | | Method | X-RAY DIFFRACTION 2.977 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 1PE, 1Q5, OLA, OLC, PGW, SO4 |
Dore, A.S., Okrasa, K., Patel, J.C., Serrano-Vega, M., Bennett, K., Cooke, R.M., Errey, J.C., Jazayeri, A., Khan, S., Tehan, B., Weir, M., Wiggin, G.R., Marshall, F.H. (2014) Nature 511: 557-562 | Released | 2014-07-02 | | Method | X-RAY DIFFRACTION 2.6 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 2U8, MES, OLA |
Jazayeri, A., Dore, A.S., Lamb, D., Krishnamurthy, H., Southall, S.M., Baig, A.H., Bortolato, A., Koglin, M., Robertson, N.J., Errey, J.C., Andrews, S.P., Brown, A.J.H., Cooke, R.M., Weir, M., Marshall, F.H. (2016) Nature 533: 274-277 | Released | 2016-04-20 | | Method | X-RAY DIFFRACTION 2.5 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 5MV, OLA, PE5, TLA |
Segala, E., Guo, D., Cheng, R.K.Y., Bortolato, A., Deflorian, F., Dore, A.S., Errey, J.C., Heitman, L.H., Ijzerman, A.P., Marshall, F.H., Cooke, R.M. (2016) J Med Chem 59: 6470-6479 | Released | 2016-06-29 | | Method | X-RAY DIFFRACTION 1.72 Å | | Organisms | | | Macromolecule | | | Unique Ligands | CLR, NA, OLA, OLB, OLC, ZMA |
Segala, E., Guo, D., Cheng, R.K.Y., Bortolato, A., Deflorian, F., Dore, A.S., Errey, J.C., Heitman, L.H., Ijzerman, A.P., Marshall, F.H., Cooke, R.M. (2016) J Med Chem 59: 6470-6479 | Released | 2016-06-29 | | Method | X-RAY DIFFRACTION 1.9 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 6DY, CLR, NA, OLA, OLB, OLC |
Segala, E., Guo, D., Cheng, R.K.Y., Bortolato, A., Deflorian, F., Dore, A.S., Errey, J.C., Heitman, L.H., Ijzerman, A.P., Marshall, F.H., Cooke, R.M. (2016) J Med Chem 59: 6470-6479 | Released | 2016-06-29 | | Method | X-RAY DIFFRACTION 2.002 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 6DZ, CLR, HTO, NA, OLA, OLB, OLC |
Segala, E., Guo, D., Cheng, R.K.Y., Bortolato, A., Deflorian, F., Dore, A.S., Errey, J.C., Heitman, L.H., Ijzerman, A.P., Marshall, F.H., Cooke, R.M. (2016) J Med Chem 59: 6470-6479 | Released | 2016-06-29 | | Method | X-RAY DIFFRACTION 2.2 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 6DX, CLR, NA, OLA, OLB |
Segala, E., Guo, D., Cheng, R.K.Y., Bortolato, A., Deflorian, F., Dore, A.S., Errey, J.C., Heitman, L.H., Ijzerman, A.P., Marshall, F.H., Cooke, R.M. (2016) J Med Chem 59: 6470-6479 | Released | 2016-06-29 | | Method | X-RAY DIFFRACTION 2.1 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 6DV, CLR, NA, OLA, OLB, OLC |
Oswald, C., Rappas, M., Kean, J., Dore, A.S., Errey, J.C., Bennett, K., Deflorian, F., Christopher, J.A., Jazayeri, A., Mason, J.S., Congreve, M., Cooke, R.M., Marshall, F.H. (2016) Nature 540: 462-465 | Released | 2016-12-07 | | Method | X-RAY DIFFRACTION 2.8 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 79K, CLR, MLI, OLA |
Cheng, R.K.Y., Segala, E., Robertson, N., Deflorian, F., Dore, A.S., Errey, J.C., Fiez-Vandal, C., Marshall, F.H., Cooke, R.M. (2017) Structure 25: 1275-1285.e4 | Released | 2017-07-26 | | Method | X-RAY DIFFRACTION 2 Å | | Organisms | | | Macromolecule | | | Unique Ligands | CLR, NA, OLA, OLC, TEP |
Cheng, K.Y.R., Segala, E., Robertson, N., Deflorian, F., Dore, A.S., Errey, J.C., Fiez-Vandal, C., Marshall, F.H., Cooke, R.M. (2017) Structure 25: 1275-1285.e4 | Released | 2017-07-26 | | Method | X-RAY DIFFRACTION 2.1 Å | | Organisms | | | Macromolecule | | | Unique Ligands | CFF, CLR, NA, OLA, OLC, TAR |
Cheng, R.K.Y., Segala, E., Robertson, N., Deflorian, F., Dore, A.S., Errey, J.C., Fiez-Vandal, C., Marshall, F.H., Cooke, R.M. (2017) Structure 25: 1275-1285.e4 | Released | 2017-07-26 | | Method | X-RAY DIFFRACTION 2.8 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 8JN, CLR, NA, OLA, OLC, TAR |
Cheng, R.K.Y., Segala, E., Robertson, N., Deflorian, F., Dore, A.S., Errey, J.C., Fiez-Vandal, C., Marshall, F.H., Cooke, R.M. (2017) Structure 25: 1275-1285.e4 | Released | 2017-07-26 | | Method | X-RAY DIFFRACTION 3.303 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 8K8, SO4 |
Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N. (2017) Nature 545: 112-115 | Released | 2017-05-03 | | Method | X-RAY DIFFRACTION 2.801 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 8TZ, NA, PO4 |
Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N. (2017) Nature 545: 112-115 | Released | 2017-05-03 | | Method | X-RAY DIFFRACTION 3.6 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 8UN, NA |
Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N. (2017) Nature 545: 112-115 | Released | 2017-05-03 | | Method | X-RAY DIFFRACTION 4 Å | | Organisms | | | Macromolecule | |
Rappas, M., Jazayeri, A., Brown, A.J.H., Kean, J., Errey, J.C., Robertson, N., Fiez-Vandal, C., Andrews, S.P., Congreve, M., Bortolato, A., Mason, J.S., Baig, A.H., Teobald, I., Dore, A.S., Weir, M., Cooke, R.M., Marshall, F.H. (2017) Nature 546: 254-258 | Released | 2017-06-14 | | Method | X-RAY DIFFRACTION 3.7 Å | | Organisms | | | Macromolecule | | | Unique Ligands | NAG, SOG | | Unique branched monosaccharides | NAG |
Robertson, N., Rappas, M., Dore, A.S., Brown, J., Bottegoni, G., Koglin, M., Cansfield, J., Jazayeri, A., Cooke, R.M., Marshall, F.H. (2018) Nature 553: 111-114 | Released | 2018-01-10 | | Method | X-RAY DIFFRACTION 2.7 Å | | Organisms | | | Macromolecule | | | Unique Ligands | 9P2, CIT, OLA, TLA |
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