RCSB PDB: Search

5TCH \| pdb_00005tch	Download File View File

Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form, TrpA-G66V mutant

Michalska, K., Maltseva, N., Jedrzejczak, R., Wellington, S., Nag, P.P., Fisher, S.L., Schreiber, S.L., Hung, D.T., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)

(2017) Nat Chem Biol 13: 943-950

Released	2017-05-31
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	Tryptophan synthase alpha chain (protein) Tryptophan synthase beta chain (protein)
Unique Ligands	FMT, MLI

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5TCI \| pdb_00005tci	Download File View File

Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form

Michalska, K., Maltseva, N., Jedrzejczak, R., Wellington, S., Nag, P.P., Fisher, S.L., Schreiber, S.L., Hung, D.T., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)

(2017) Nat Chem Biol 13: 943-950

Released	2017-05-31
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	Tryptophan synthase alpha chain (protein) Tryptophan synthase beta chain (protein)
Unique Ligands	79V, FMT, MLI

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5TCJ \| pdb_00005tcj	Download File View File

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate and BRD4592-bound form

Michalska, K., Maltseva, N., Jedrzejczak, R., Wellington, S., Nag, P.P., Fisher, S.L., Schreiber, S.L., Hung, D.T., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)

(2017) Nat Chem Biol 13: 943-950

Released	2017-05-31
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	Tryptophan synthase alpha chain (protein) Tryptophan synthase beta chain (protein)
Unique Ligands	79V, CS, FMT, MLI, P1T

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6DWE \| pdb_00006dwe	Download File View File

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD0059-bound form

Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)

To be published

Released	2018-07-11
Method	X-RAY DIFFRACTION 2.691 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	Tryptophan synthase alpha chain (protein) Tryptophan synthase beta chain (protein)
Unique Ligands	ACT, CS, EDO, FMT, HDJ, MLA, MLI, P1T, PGE

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6E9P \| pdb_00006e9p	Download File View File

Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059 bound

Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)

To be published

Released	2018-08-08
Method	X-RAY DIFFRACTION 2.569 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	Tryptophan synthase alpha chain (protein) Tryptophan synthase beta chain (protein)
Unique Ligands	ACT, EDO, FMT, HDJ, MLA, MLT

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6U6C \| pdb_00006u6c	Download File View File

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form

Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)

(2020) Protein Sci 29: 779-788

Released	2020-09-02
Method	X-RAY DIFFRACTION 2.402 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	Tryptophan synthase alpha chain (protein) Tryptophan synthase beta chain (protein)
Unique Ligands	ACT, ALA, EDO, EPE, FMT, K, MLI, NA, P1T, PEG, PGE, PZV

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6UAP \| pdb_00006uap	Download File View File

Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound

Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)

To be published

Released	2019-10-30
Method	X-RAY DIFFRACTION 2.745 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	Tryptophan synthase alpha chain (protein) Tryptophan synthase beta chain (protein)
Unique Ligands	ACT, EDO, FMT, H9V, MLA, MLT

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6UB9 \| pdb_00006ub9	Download File View File

Crystal structure of tryptophan synthase from M. tuberculosis - AMINOACRYLATE- AND BRD6309-BOUND FORM

Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)

To be published

Released	2019-09-25
Method	X-RAY DIFFRACTION 2.783 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	Tryptophan synthase alpha chain (protein) Tryptophan synthase beta chain (protein)
Unique Ligands	ACT, CS, EDO, FMT, H9V, MLA, P1T, PGE

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6USA \| pdb_00006usa	Download File View File

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form

Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)

(2020) Protein Sci 29: 779-788

Released	2020-09-30
Method	X-RAY DIFFRACTION 2.406 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	Tryptophan synthase alpha chain (protein) Tryptophan synthase beta chain (protein)
Unique Ligands	ACT, EDO, FMT, K, MLI, NA, P1T, PEG, PZJ, SO4

5TCH | pdb_00005tch

Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form, TrpA-G66V mutant

5TCI | pdb_00005tci

Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form

5TCJ | pdb_00005tcj

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate and BRD4592-bound form

6DWE | pdb_00006dwe

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD0059-bound form

6E9P | pdb_00006e9p

Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059 bound

6U6C | pdb_00006u6c

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form

6UAP | pdb_00006uap

Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound

6UB9 | pdb_00006ub9

Crystal structure of tryptophan synthase from M. tuberculosis - AMINOACRYLATE- AND BRD6309-BOUND FORM

6USA | pdb_00006usa

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form

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5TCH | pdb_00005tch

5TCI | pdb_00005tci

5TCJ | pdb_00005tcj

6DWE | pdb_00006dwe

6E9P | pdb_00006e9p

6U6C | pdb_00006u6c

6UAP | pdb_00006uap

6UB9 | pdb_00006ub9

6USA | pdb_00006usa