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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Phan, J."

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Search Summary

This query matches 90 Structures.

Refinements

Structure Determination Methodology

experimental (90)

Scientific Name of Source Organism

	Homo sapiens (77)
	Escherichia coli (5)
	Aquifex aeolicus VF5 (2)
	Tobacco etch virus (2)
	Yersinia pestis (2)
	Aquifex aeolicus (1)
	Variola virus (1)
	Yersinia enterocolitica (1)
	Yersinia pestis CO92 (1)
	synthetic construct (1)

Taxonomy

	Eukaryota (77)
	Bacteria (10)
	Riboviria (2)
	Riboviria (RNA viruses and viroids) (1)
	Varidnaviria (1)
	other sequences (1)

Experimental Method

X-RAY DIFFRACTION (90)

Polymer Entity Type

Protein (90)

Refinement Resolution (Å)

	1.0 - 1.5 (7)
	1.5 - 2.0 (60)
	2.0 - 2.5 (18)
	2.5 - 3.0 (4)
	3.5 - 4.0 (1)

Release Date

	1995 - 1999 (1)
	2000 - 2004 (13)
	2005 - 2009 (9)
	2010 - 2014 (17)
	2015 - 2019 (36)
	2020 - 2024 (11)
	2025 - 2029 (3)

Enzyme Classification Name

	Hydrolases (51)
	Transferases (10)
	Ligases (2)

Symmetry Type

	Asymmetric (82)
	Cyclic (16)
	Dihedral (3)

SCOP Classification

	Alpha and beta proteins (a/b) (45)
	Artifacts (44)
	All alpha proteins (42)
	Alpha and beta proteins (a+b) (11)
	All beta proteins (10)

AllSelected

1 to 25 of 90 Structures

Page 1 of 4

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1EV5 \| pdb_00001ev5	Download File View File

CRYSTAL STRUCTURE ANALYSIS OF ALA167 MUTANT OF ESCHERICHIA COLI

Phan, J., Mahdavian, E., Nivens, M.C., Minor, W., Berger, S., Spencer, H.T., Dunlap, R.B., Lebioda, L.

(2000) Biochemistry 39: 6969-6978

Released	2000-05-03
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Escherichia coli
Macromolecule	THYMIDYLATE SYNTHASE (protein)
Unique Ligands	SO4

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1EV8 \| pdb_00001ev8	Download File View File

CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI

Phan, J., Mahdavian, E., Nivens, M.C., Minor, W., Berger, S., Spencer, H.T., Dunlap, R.B., Lebioda, L.

(2000) Biochemistry 39: 6969-6978

Released	2000-05-03
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli
Macromolecule	THYMIDYLATE SYNTHASE (protein)

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1EVF \| pdb_00001evf	Download File View File

CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI

Phan, J., Mahdavian, E., Nivens, M.C., Minor, W., Berger, S., Spencer, H.T., Dunlap, R.B., Lebioda, L.

(2000) Biochemistry 39: 6969-6978

Released	2000-05-03
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Escherichia coli
Macromolecule	THYMIDYLATE SYNTHASE (protein)
Unique Ligands	SO4

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1EVG \| pdb_00001evg	Download File View File

CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI WITH UNMODIFIED CATALYTIC CYSTEINE

Phan, J., Mahdavian, E., Nivens, M.C., Minor, W., Berger, S., Spencer, H.T., Dunlap, R.B., Lebioda, L.

(2000) Biochemistry 39: 6969-6978

Released	2000-05-03
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli
Macromolecule	THYMIDYLATE SYNTHASE (protein)
Unique Ligands	SO4

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1HVY \| pdb_00001hvy	Download File View File

Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation

Phan, J., Koli, S., Minor, W., Dunlap, R.B., Berger, S.H., Lebioda, L.

(2001) Biochemistry 40: 1897-1902

Released	2001-01-31
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	THYMIDYLATE SYNTHASE (protein)
Unique Ligands	BME, D16, UMP

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1HW3 \| pdb_00001hw3	Download File View File

STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS

Phan, J., Steadman, J.D., Koli, S., Ding, W.C., Minor, W., Dunlap, R.B., Berger, S.H., Lebioda, L.

(2001) J Biological Chem 276: 14170-14177

Released	2001-01-24
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	THYMIDYLATE SYNTHASE (protein)
Unique Ligands	EDO, SO4

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1HW4 \| pdb_00001hw4	Download File View File

STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS

Phan, J., Steadman, J.D., Koli, S., Ding, W.C., Minor, W., Dunlap, R.B., Berger, S.H., Lebioda, L.

(2001) J Biological Chem 276: 14170-14177

Released	2001-01-24
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	THYMIDYLATE SYNTHASE (protein)
Unique Ligands	EDO, SO4

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1LVB \| pdb_00001lvb	Download File View File

CATALYTICALLY INACTIVE TOBACCO ETCH VIRUS PROTEASE COMPLEXED WITH SUBSTRATE

Phan, J., Zdanov, A., Evdokimov, A.G., Tropea, J.E., Peters III, H.K., Kapust, R.B., Li, M., Wlodawer, A., Waugh, D.S.

(2002) J Biological Chem 277: 50564-50572

Released	2002-11-27
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Tobacco etch virus
Macromolecule	CATALYTIC DOMAIN OF THE NUCLEAR INCLUSION PROTEIN A (NIA) (protein) OLIGOPEPTIDE SUBSTRATE FOR THE PROTEASE (protein)
Unique Ligands	GOL

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1LVM \| pdb_00001lvm	Download File View File

CATALYTICALLY ACTIVE TOBACCO ETCH VIRUS PROTEASE COMPLEXED WITH PRODUCT

Phan, J., Zdanov, A., Evdokimov, A.G., Tropea, J.E., Peters III, H.K., Kapust, R.B., Li, M., Wlodawer, A., Waugh, D.S.

(2002) J Biological Chem 277: 50564-50572

Released	2002-11-27
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Tobacco etch virus
Macromolecule	CATALYTIC DOMAIN OF THE NUCLEAR INCLUSION PROTEIN A (NIA) (protein) OLIGOPEPTIDE SUBSTRATE FOR THE PROTEASE (protein)

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1ORJ \| pdb_00001orj	Download File View File

FLAGELLAR EXPORT CHAPERONE

Evdokimov, A.G., Phan, J., Tropea, J.E., Routzahn, K.M., Peters III, H.K., Pokross, M., Waugh, D.S.

(2003) Nat Struct Biol 10: 789-793

Released	2003-09-16
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Aquifex aeolicus VF5
Macromolecule	flagellar protein FliS (protein)

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1ORY \| pdb_00001ory	Download File View File

FLAGELLAR EXPORT CHAPERONE IN COMPLEX WITH ITS COGNATE BINDING PARTNER

Evdokimov, A.G., Phan, J., Tropea, J.E., Routzahn, K.M., Peters III, H.K., Pokross, M., Waugh, D.S.

(2003) Nat Struct Biol 10: 789-793

Released	2003-09-16
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Aquifex aeolicus Aquifex aeolicus VF5
Macromolecule	Flagellin (protein) flagellar protein FliS (protein)
Unique Ligands	PO4

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1QQQ \| pdb_00001qqq	Download File View File

CRYSTAL STRUCTURE ANALYSIS OF SER254 MUTANT OF ESCHERICHIA COLI THYMIDYLATE SYNTHASE

Fantz, C., Shaw, D., Jennings, W., Forsthoefel, A., Kitchens, M., Phan, J., Minor, W., Lebioda, L., Berger, F.G., Spencer, H.T.

(2000) Mol Pharmacol 57: 359-366

Released	1999-06-14
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Escherichia coli
Macromolecule	THYMIDYLATE SYNTHASE (protein)
Unique Ligands	SO4

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1QZ0 \| pdb_00001qz0	Download File View File

Crystal Structure of the Yersinia Pestis Phosphatase YopH in Complex with a Phosphotyrosyl Mimetic-Containing Hexapeptide

Phan, J., Lee, K., Cherry, S., Tropea, J.E., Burke Jr, T.R., Waugh, D.S.

(2003) Biochemistry 42: 13113-13121

Released	2003-11-25
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Yersinia pestis
Macromolecule	ASP-ALA-ASP-GLU-FTY-LEU-NH2 (protein) Protein-tyrosine phosphatase yopH (protein)

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1TTW \| pdb_00001ttw	Download File View File

Crystal structure of the Yersinia Pestis type III secretion chaperone SycH in complex with a stable fragment of YscM2

Phan, J., Tropea, J.E., Waugh, D.S.

(2004) Acta Crystallogr D Biol Crystallogr 60: 1591-1599

Released	2004-08-31
Method	X-RAY DIFFRACTION 2.38 Å
Organisms	Yersinia enterocolitica Yersinia pestis CO92
Macromolecule	YscM2 (protein) secretion chaperone (protein)

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1ZW0 \| pdb_00001zw0	Download File View File

Crystal structure of the Yersinia Type III Secretion protein YscE

Phan, J., Austin, B.P., Waugh, D.S.

(2005) Protein Sci 14: 2759-2763

Released	2005-08-23
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Yersinia pestis
Macromolecule	type III secretion protein (protein)

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2AOA \| pdb_00002aoa	Download File View File

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain

Phan, J., Shi, Z.D., Burke, T.R., Waugh, D.S.

(2005) J Mol Biology 353: 104-115

Released	2005-10-04
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Homo sapiens
Macromolecule	Growth factor receptor-bound protein 2 (protein)
Unique Ligands	P33, S1S

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2AOB \| pdb_00002aob	Download File View File

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain

Phan, J., Shi, Z.D., Burke, T.R., Waugh, D.S.

(2005) J Mol Biology 353: 104-115

Released	2005-10-04
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Growth factor receptor-bound protein 2 (protein)
Unique Ligands	S1S

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2P4D \| pdb_00002p4d	Download File View File

Structure-assisted discovery of Variola major H1 phosphatase inhibitors

Phan, J., Tropea, J.E., Waugh, D.S.

(2007) Acta Crystallogr D Biol Crystallogr D63: 698-704

Released	2007-05-29
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Variola virus
Macromolecule	Dual specificity protein phosphatase (protein)

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3JZO \| pdb_00003jzo	Download File View File

Human MDMX liganded with a 12mer peptide (pDI)

Schonbrunn, E., Phan, J.

(2010) J Biological Chem 285: 2174-2183

Released	2009-11-10
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Protein Mdm4 (protein) pDI peptide (12mer) (protein)
Unique Ligands	K

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3JZP \| pdb_00003jzp	Download File View File

Human MDMX liganded with a 12mer peptide inhibitor (pDI6W)

Schonbrunn, E., Phan, J.

(2010) J Biological Chem 285: 2174-2183

Released	2009-11-10
Method	X-RAY DIFFRACTION 1.74 Å
Organisms	Homo sapiens
Macromolecule	Protein Mdm4 (protein) pDI6W peptide (12mer) (protein)
Unique Ligands	K

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3JZQ \| pdb_00003jzq	Download File View File

Human MDMX liganded with a 12mer peptide inhibitor (pDIQ)

Schonbrunn, E., Phan, J.

(2010) J Biological Chem 285: 2174-2183

Released	2009-11-10
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Protein Mdm4 (protein) pDIQ peptide (12mer) (protein)
Unique Ligands	SO4

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3JZR \| pdb_00003jzr	Download File View File

Human MDM2 liganded with a 12mer peptide inhibitor (pDI6W)

Schonbrunn, E., Phan, J.

(2010) J Biological Chem 285: 2174-2183

Released	2009-11-10
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein) pDI6W peptide (12mer) (protein)

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3JZS \| pdb_00003jzs	Download File View File

Human MDM2 liganded with a 12mer peptide inhibitor (pDIQ)

Schonbrunn, E., Phan, J.

(2010) J Biological Chem 285: 2174-2183

Released	2009-11-10
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein) pDIQ peptide (12mer) (protein)
Unique Ligands	EDO