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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Rout, M."

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Search Summary

This query matches 17 Structures.

Refinements

Structure Determination Methodology

experimental (17)

Scientific Name of Source Organism

Homo sapiens (17)

Taxonomy

Eukaryota (17)

Experimental Method

X-RAY DIFFRACTION (17)

Polymer Entity Type

Protein (17)

Refinement Resolution (Å)

	0.5 - 1.0 (1)
	1.5 - 2.0 (2)
	2.0 - 2.5 (6)
	2.5 - 3.0 (6)
	3.0 - 3.5 (2)

Release Date

	1990 - 1994 (1)
	1995 - 1999 (1)
	2000 - 2004 (1)
	2010 - 2014 (1)
	2015 - 2019 (12)
	2020 - 2024 (1)

Enzyme Classification Name

	Hydrolases (1)
	Transferases (1)

Membrane Protein Annotation

OPM (1)

Symmetry Type

	Asymmetric (9)
	Cyclic (11)

SCOP Classification

	Alpha and beta proteins (a/b) (9)
	All beta proteins (2)
	All alpha proteins (2)
	Alpha and beta proteins (a+b) (1)
	Artifacts (2)
	Peptides (1)

AllSelected

1 to 17 of 17 Structures

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1AX8 \| pdb_00001ax8	Download File View File

Human obesity protein, leptin

Zhang, F., Beals, J.M., Briggs, S.L., Clawson, D.K., Wery, J.-P., Schevitz, R.W.

(1997) Nature 387: 206-209

Released	1998-11-25
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	OBESITY PROTEIN (protein)

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1BBC \| pdb_00001bbc	Download File View File

STRUCTURE OF RECOMBINANT HUMAN RHEUMATOID ARTHRITIC SYNOVIAL FLUID PHOSPHOLIPASE A2 AT 2.2 ANGSTROMS RESOLUTION

Wery, J.-P., Schevitz, R.W., Clawson, D.K., Bobbitt, J.L., Dow, E.R., Gamboa, G., Goodsonjunior, T., Hermann, R.B., Kramer, R.M., Mcclure, D.B., Mihelich, E.D., Putnam, J.E., Sharp, J.D., Stark, D.H., Teater, C., Warrick, M.W., Jones, N.D.

(1991) Nature 352: 79-82

Released	1993-10-31
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHOLIPASE A2 (protein)

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1ET1 \| pdb_00001et1	Download File View File

CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION

Jin, L., Briggs, S.L., Chandrasekhar, S., Chirgadze, N.Y., Clawson, D.K., Schevitz, R.W., Smiley, D.L., Tashjian, A.H., Zhang, F.

(2000) J Biological Chem 275: 27238-27244

Released	2000-09-06
Method	X-RAY DIFFRACTION 0.9 Å
Organisms	Homo sapiens
Macromolecule	PARATHYROID HORMONE (protein)
Unique Ligands	NA

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4MF3 \| pdb_00004mf3	Download File View File

Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist

Martinez-Perez, J.A., Iyengar, S., Shannon, H.E., Bleakman, D., Alt, A., Clawson, D.K., Arnold, B.M., Bell, M.G., Bleisch, T.J., Castano, A.M., Del Prado, M., Dominguez, E., Escribano, A.M., Filla, S.A., Ho, K.H., Hudziak, K.J., Jones, C.K., Katofiasc, M.A., Mateo, A., Mathes, B.M., Mattiuz, E.L., Ogden, A.M.L., Phebus, L.A., Simmons, R.M.A., Stack, D.R., Stratford, R.E., Winter, M.A., Wu, Z., Ornstein, P.L.

(2013) Bioorg Med Chem Lett 23: 6463-6466

Released	2014-05-07
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Glutamate receptor ionotropic, kainate 1 (protein)
Unique Ligands	SXI

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4XAQ \| pdb_00004xaq	Download File View File

mGluR2 ECD and mGluR3 ECD with ligands

Clawson, D.K.

(2015) J Med Chem 58: 1776-1794

Released	2015-02-04
Method	X-RAY DIFFRACTION 2.21 Å
Organisms	Homo sapiens
Macromolecule	Metabotropic glutamate receptor 2 (protein)
Unique Ligands	40F, CL, SO4

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4XAR \| pdb_00004xar	Download File View File

mGluR2 ECD and mGluR3 ECD complex with ligands

Clawson, D.K.

(2015) J Med Chem 58: 1776-1794

Released	2015-02-11
Method	X-RAY DIFFRACTION 2.26 Å
Organisms	Homo sapiens
Macromolecule	Metabotropic glutamate receptor 3 (protein)
Unique Ligands	40F, IOD

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4XAS \| pdb_00004xas	Download File View File

mGluR2 ECD ligand complex

Clawson, D.K.

(2015) J Med Chem 58: 1776-1794

Released	2015-02-04
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Metabotropic glutamate receptor 2 (protein)
Unique Ligands	40H

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5CNI \| pdb_00005cni	Download File View File

mGlu2 with Glutamate

Clawson, D.K., Atwell, S., Monn, J.A.

(2015) J Med Chem 58: 7526-7548

Released	2015-09-09
Method	X-RAY DIFFRACTION 2.69 Å
Organisms	Homo sapiens
Macromolecule	Metabotropic glutamate receptor 2 (protein)
Unique Ligands	CL, GLU, NA, NAG

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5CNJ \| pdb_00005cnj	Download File View File

mGlur2 with glutamate analog

Monn, J.A., Clawson, D.K.

(2015) J Med Chem 58: 7526-7548

Released	2015-09-09
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	Metabotropic glutamate receptor 2 (protein)
Unique Ligands	52Q, NAG

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5CNK \| pdb_00005cnk	Download File View File

mglur3 with glutamate

Monn, J.A., Clawson, D.K.

(2015) J Med Chem 58: 7526-7548

Released	2015-09-09
Method	X-RAY DIFFRACTION 3.15 Å
Organisms	Homo sapiens
Macromolecule	Metabotropic glutamate receptor 3 (protein)
Unique Ligands	GLU, IOD

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5CNM \| pdb_00005cnm	Download File View File

mGluR3 complexed with glutamate analog

Monn, J.A., Clawson, D.K., McKinzie, D.

(2015) J Med Chem 58: 7526-7548

Released	2015-09-09
Method	X-RAY DIFFRACTION 2.84 Å
Organisms	Homo sapiens
Macromolecule	Metabotropic glutamate receptor 3 (protein)
Unique Ligands	52Q, CL, MG, SO4

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5KN5 \| pdb_00005kn5	Download File View File

TGFalpha/Epiregulin complex with neutralizing antibody LY3016859

Atwell, S., Boyles, J.S., Clawson, D.K., Druzina, Z., Josef, G.H., Weichert, K., Witcher, D.R.

(2016) Protein Sci 25: 2028-2036

Released	2016-08-31
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Epiregulin Antibody LY3016859 Fab Heavy Chain (protein) Epiregulin Antibody LY3016859 Fab Light Chain (protein) Protransforming growth factor alpha (protein)
Unique Ligands	SO4, ZN

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6B7H \| pdb_00006b7h	Download File View File

Structure of mGluR3 with an agonist

Monn, J.A., Clawson, D.K.

(2018) J Med Chem 61: 2303-2328

Released	2018-04-25
Method	X-RAY DIFFRACTION 2.82 Å
Organisms	Homo sapiens
Macromolecule	Metabotropic glutamate receptor 3 (protein)
Unique Ligands	CA, CWY, NAG
Unique branched monosaccharides	NAG

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6BL8 \| pdb_00006bl8	Download File View File

Predicting the Conformational Variability of Abl Tyrosine Kinase Using Molecular Dynamics Simulations and Markov State Models

Clawson, D.K., Gao, C.

(2018) J Chem Theory Comput 14: 2721-2732

Released	2018-03-07
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase ABL1 (protein)
Unique Ligands	PVB, SO4

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6NOU \| pdb_00006nou	Download File View File

An scFv derived from ixekizumab

Durbin, J.D., Clawson, D.K., Lu, F., Tian, Y., Lu, J., Atwell, S.

(2019) MAbs 11: 1175-1190

Released	2019-06-19
Method	X-RAY DIFFRACTION 1.914 Å
Organisms	Homo sapiens
Macromolecule	scFv derived from ixekizumab (protein)
Unique Ligands	GOL

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6NOV \| pdb_00006nov	Download File View File

A Fab derived from ixekizumab

Durbin, J.D., Clawson, D.K., Lu, F., Tian, Y., Lu, J., Schmitt, M., Atwell, S.

(2019) MAbs 11: 1175-1190

Released	2019-06-19
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Homo sapiens
Macromolecule	Fab Heavy Chain (protein) Fab Light Chain (protein)
Unique Ligands	12P

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7KCO \| pdb_00007kco	Download File View File

ROR gamma in complex with SCR2 and compound 3

Durbin, J.D., Guo, S.Y., Stout, S.L., Clawson, D.K.

(2021) J Med Chem 64: 5470-5484

Released	2021-04-21
Method	X-RAY DIFFRACTION 1.86 Å
Organisms	Homo sapiens
Macromolecule	Nuclear receptor ROR-gamma (protein) Peptide GLU-LYS-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP-SER (protein)
Unique Ligands	GOL, WB7

1 to 17 of 17 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1AX8 | pdb_00001ax8

Human obesity protein, leptin

1BBC | pdb_00001bbc

STRUCTURE OF RECOMBINANT HUMAN RHEUMATOID ARTHRITIC SYNOVIAL FLUID PHOSPHOLIPASE A2 AT 2.2 ANGSTROMS RESOLUTION

1ET1 | pdb_00001et1

CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION

4MF3 | pdb_00004mf3

Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist

4XAQ | pdb_00004xaq

mGluR2 ECD and mGluR3 ECD with ligands

4XAR | pdb_00004xar

mGluR2 ECD and mGluR3 ECD complex with ligands

4XAS | pdb_00004xas

mGluR2 ECD ligand complex

5CNI | pdb_00005cni

mGlu2 with Glutamate

5CNJ | pdb_00005cnj

mGlur2 with glutamate analog

5CNK | pdb_00005cnk

mglur3 with glutamate

5CNM | pdb_00005cnm

mGluR3 complexed with glutamate analog

5KN5 | pdb_00005kn5

TGFalpha/Epiregulin complex with neutralizing antibody LY3016859

6B7H | pdb_00006b7h

Structure of mGluR3 with an agonist

6BL8 | pdb_00006bl8

Predicting the Conformational Variability of Abl Tyrosine Kinase Using Molecular Dynamics Simulations and Markov State Models

6NOU | pdb_00006nou

An scFv derived from ixekizumab

6NOV | pdb_00006nov

A Fab derived from ixekizumab

7KCO | pdb_00007kco

ROR gamma in complex with SCR2 and compound 3

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1AX8 | pdb_00001ax8

1BBC | pdb_00001bbc

1ET1 | pdb_00001et1

4MF3 | pdb_00004mf3

4XAQ | pdb_00004xaq

4XAR | pdb_00004xar

4XAS | pdb_00004xas

5CNI | pdb_00005cni

5CNJ | pdb_00005cnj

5CNK | pdb_00005cnk

5CNM | pdb_00005cnm

5KN5 | pdb_00005kn5

6B7H | pdb_00006b7h

6BL8 | pdb_00006bl8

6NOU | pdb_00006nou

6NOV | pdb_00006nov

7KCO | pdb_00007kco